Economic Analysis of Catheter-Directed Thrombolysis for Intermediate-Risk Pulmonary Embolism.

Background: Pulmonary embolism is associated with a significant burden of morbidity, mortality, and health care costs. Catheter-directed thrombolysis has emerged as a promising option for patients with intermediate-risk pulmonary embolism which aims to improve outcomes over standard anticoagulation.

Methods: We constructed a decision-analytic model comparing the cost-effectiveness of catheter-directed thrombolysis to anticoagulation alone for the management of intermediate-risk pulmonary embolism.

Facet dependent ultralow thermal conductivity of zinc oxide coated silver fabric for thermoelectric devices.

The conversion efficiency of a thermoelectric power generator depends on the dimensionless figure-of-merit (ZT) of the constituent thermoelectric materials, which is mainly determined by their Seebeck coefficient as well as the electrical and thermal conductivity. ZnO holds promise for thermoelectric applications, yet its use is currently limited by low electrical conductivity and high thermal conductivity. Herein, we demonstrate how thermal conductivity of ZnO can be significantly reduced by intelligently combining it with a cellulose-based Ag fabric using a one-step hydrothermal method, and how different ratios of zinc nitrate hexahydrate (ZNH) to hexamethylenetetramine (HMT) can be used to fine-tune the thermoelectric performance of the resulting composite.

Ageing and Functional Disability: An Unbreakable Bond.

This study aimed to assess the predominant predictors of functional disability in terms of involvement of activity of daily living (ADL) of urban geriatric subjects of Varanasi, India. This community-based cross-sectional study was undertaken on 616 urban geriatric subjects, selected through a multistage sampling procedure. The functional disability of subjects was assessed by using Barthel's Index of ADL.

Neck Pain Secondary to Post Radiation Fibrosis Managed With Ultrasound-Guided Adhesiolysis.

Background: Radiation therapy may result in complications, including fibrosis, which can result in pain and difficulty with movement - especially in the neck.

Case Presentation: A 52-year-old man with right-sided vague neck pain unresponsive to conservative management had a computed tomography scan that showed a vagal paraganglioma in the carotid sheath surrounding the right carotid arteries and internal jugular vein. Following radiation therapy, he noticed a new pain in his right jaw and neck worse with certain movements of the neck.

Photocatalytic degradation of fluoroquinolone antibiotics using chitosan biopolymer functionalized copper oxide nanoparticles prepared by facile sonochemical method.

Photocatalytic degradation is an excellent method for removing pharmaceutical residues due to their simplicity, ecological benignity, high efficiency, and exceptional stability. Herein, we demonstrate the sonochemically synthesised chitosan biopolymer functionalized copper oxide nanoparticles as an efficient photocatalyst for the degradation of fluoroquinolone-based antibiotics. The X-ray diffraction Rietveld refinement revealed the formation of single-phase copper oxide (CuO) with a monoclinic structure.

Role of mineral nutrients other than iron in pregnancy: under recognized opportunities to improve maternal/fetal outcomes: a literature review.

Background: Anemia during pregnancy is an important global health concern, affecting 40% of women worldwide, and iron deficiency shares a significant proportion of the burden. From conception to birth, pregnancy is a period when women undergo metabolic and physiological changes. The nutritional needs are higher during pregnancy; thus, adequate nutrition is essential to maintain fetal growth and development.

Intraoperative neurophysiological monitoring and spinal cord stimulator implantation.

Introduction: Spinal cord injury (SCI) is one of the most dreaded complications after spinal cord stimulation (SCS) implantation surgery. As a result, intraoperative neurophysiological monitoring (IONM) has been proposed to avoid accidental damage to nervous structures under anesthesia and confirm positioning for optimal stimulation. Our study uses a large administrative claims database to determine the 30-day risk of SCI after SCS implantation.

"Does the Exploration of the Temporomandibular Joint Using a Deep Subfascial Technique Result in a Superior Operative Outcome?".

Purpose: The literature is replete with various approaches for the temporomandibular joint (TMJ), each with its own distinct advantages and disadvantages. None of these approaches, however, have been associated with superior operative outcomes. The purpose of this study was to measure the efficacy of three operative approaches to TMJ, namely superficial, subfascial, and deep subfascial approaches.

Differential expression of programmed death 1 (PD-1) on various immune cells and its role in human leprosy.

Leprosy is a chronic bacterial disease caused by . Leprosy patients have been found to have defects in T cells activation, which is critical to the clearance of the bacilli. Treg cell suppression is mediated by inhibitory cytokines such as IL10, IL-35 and TGF-β and its frequency is higher in leprosy patients.

Extent, spectrum, and predictors of cognitive impairment in urban geriatric population in a district of North India.

Cognitive impairment (CI) is no longer considered a normal and inevitable change of aging. This study was carried out to assess extent, spectrum, and predictors of cognitive impairment in the participants. A community-based cross-sectional study was done on 616 urban geriatric participants of Varanasi city selected by multistage sampling procedure.

Impact assessment of Intensified Malaria Control Project in transitioning a high malaria-endemic district to a low-endemic district: an epidemiological aspect.

Intensified Malaria Control Project (IMCP) was implemented in 2005 to control malaria in all North-Eastern and Odisha states of India. The present study aimed to investigate the impact of IMCP in reducing the malaria burden in Udalguri district, Assam state of North-East India. Malaria epidemiological data were obtained for IMCP intervention (Udalguri) and nonintervention district (West Singhbhumi, Jharkhand state).

Antibiotic-resistant bacteria originating from the gut may modulate the mucosal immune response during sepsis and septic shock.

The enrichment and diversity of gut microbiota play an important role in sepsis, but the role of gut microbiota composition and early-life colonization in sepsis and septic shock has not yet been characterized. The impact of gut microbiota diversity on host immunological disorders and future treatments of inflammatory diseases are not yet fully elucidated. Further, the association between the microbiota and immune development in sepsis remains unknown, and the underlying mechanisms are not well understood.

Efficient charge transfer from organometal lead halide perovskite nanocrystals to free base -tetraphenylporphyrins.

The efficient charge transfer from methylammonium lead halide, MAPbX (X = Br, I), perovskite nanocrystals (PNCs) to 5,10,15,20-tetraphenylporphyrin (TPP) molecules has been investigated in detail. The hydrophobically-capped MAPbX PNCs exhibited bright fluorescence in the solution state. However, in the presence of TPP, the fluorescence intensity was quenched, which is ascribed to the electron transfer from the PNCs to TPP.

Where do T cell subsets stand in SARS-CoV-2 infection: an update.

An outbreak of coronavirus disease 2019 (COVID-19) emerged in China in December 2019 and spread so rapidly all around the globe. It's continued and spreading more dangerously in India and Brazil with higher mortality rate. Understanding of the pathophysiology of COVID-19 depends on unraveling of interactional mechanism of SARS-CoV-2 and human immune response.

Asymptomatic and low-density infections in India: an unexplored link.

Presently in India, high endemic zones of malaria are shifting towards low endemic zones and in this changing scenario, tackling the asymptomatic and low-density infections (LDI) would be an important factor. Role of the asymptomatic and LDI in transmitting parasites successfully to mosquito vectors needs to be systematically investigated. We here highlight the limited work done on the burden of asymptomatic Plasmodium infections in India with an emphasis on its infectiousness, and infrastructure available for the detection of LDI.

Epidemiology of malaria and anemia in high and low malaria-endemic North-Eastern districts of India.

Anemia and malaria are the two major public health problems that lead to substantial morbidity and mortality. Malaria infection destroys erythrocytes, resulting in low hemoglobin (Hb) levels known as anemia. Here we report the determinants of anemia in high and low malaria-endemic areas that would help understand which parasite densities, age, and gender-associated low Hb levels.

Lead and Pulse Generator Migration After Spinal Cord Stimulation Implantation: Insights From an Analysis of 7322 Patients.

Objectives: Lead migration (LM) after spinal cord stimulation (SCS) implantation surgery is the most common device-related complication. Our study of lead and implantable pulse generator (IPG) migration using a large administrative claims data base aims to understand rates, risk factors, and outcomes after SCS implantation.

Materials And Methods: This retrospective cohort study used the IBM® MarketScan® (Armonk, NY) Commercial and Medicare Supplemental Databases from 2016 to 2018.

Moderate Rainfall and High Humidity During the Monsoon Season, Negligence in Using Malaria Protection Methods and High Proportion of Mild Symptomatic Patients Were the Driving Forces for Upsurge of Malaria Cases in 2018 Among Tea Tribe Populations in Endemic Dolonibasti Health Sub-center, Udalguri District, Assam State, North-East India.

Malaria elimination is a global priority, which India has also adopted as a target. Despite the malaria control efforts like long-lasting insecticidal nets distribution, rounds of indoor residual spray, the introduction of bi-valent rapid diagnostic tests and artemisinin combination therapy, malaria remained consistent in Dolonibasti sub-center of Orang block primary health center (BPHC) under the district Udalguri, Assam state followed by abrupt rise in cases in 2018. Therefore, we aimed to investigate the factors driving the malaria transmission in the outbreak area of Dolonibasti sub-center.

Interaction of Bioactive Compounds of Moringa oleifera Leaves with SARS-CoV-2 Proteins to Combat COVID-19 Pathogenesis: a Phytochemical and In Silico Analysis.

Novel SARS-CoV-2 claimed a large number of human lives. The main proteins for viral entry into host cells are SARS-CoV-2 spike glycoprotein (PDB ID: 6VYB) and spike receptor-binding domain bound with ACE2 (spike RBD-ACE2; PDB ID: 6M0J). Currently, specific therapies are lacking globally.

Haplogroup diversity in the Indian population using 23 Y-STRs.

Background: A Y-STR polymorphism study is a convenient tool in molecular anthropology and forensic DNA analysis.

Aim: Through standard ethical procedures, the proposed study explored the genetic scenario in male lineage in Madhya Pradesh, a central Indian state, by Y-STR genotyping and haplogroup studies.

Subjects And Methods: Five hundred and eleven unrelated male blood samples were directly amplified, and fragment separation was done using capillary electrophoresis to generate a Y-STR profile for 23 forensic relevant markers through PowerPlex Y 23 multiplex system.

Significant boost of the stability and PLQYof CsPbBr NCs by Cu-BTC MOF.

Developing stable perovskite nanocrystals (NCs) with enhancing luminescent properties holds great importance for future potential applications in optoelectronics. Here, we engaged perovskite NCs in Cu ion-based metal-organic framework (MOF) Cu-BTC (BTC = 1,3,5-benzene tricarboxylate) by physical mixing of MOF with CsPbBr NCs in toluene solution. MOF-protected perovskite NCs achieved high photoluminescence quantum yield 96.