Familial Renal Glucosuria and Potential Pharmacogenetic Impact on SGLT2 Inhibitors.

Background: Renal glucosuria is a rare inheritable trait caused by loss-of-function variants in the gene that encodes SGLT2 (i.e., SLC5A2).

Benefits of short-term professional continuous glucose monitoring in clinical practice.

Background: The clinical utility of short-term professional continuous glucose monitoring (CGM) is uncertain.

Subjects And Methods: This is a retrospective review of 121 consecutive insulin-treated patients seen in a university-based subspecialty clinic who completed a 72-120-h professional CGM study. Based on the indications for the study, patients were divided into three groups: hyperglycemia (Hyper) (n=51), widely fluctuating glycemia (Fluctuating) (n=50), or hypoglycemia (Hypo) (n=20).

A novel case of diabetic muscle necrosis in a patient with cystic fibrosis-related diabetes.

Cystic fibrosis is a recessive autosomal disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene. Cystic fibrosis-related diabetes (CFRD) is a common comorbidity of cystic fibrosis. Diabetic myonecrosis is a rare self-limited complication of poorly controlled diabetes mellitus that commonly presents with acute, intense pain and swelling of lower extremities and responds well to conservative management.