Microbiome-Augmented Model for Predicting Knee Osteoarthritis Progression Based on Gut Microbiota and Kellgren-Lawrence Classification.

Purpose:  Knee osteoarthritis (OA) is a widespread chronic degenerative condition that may experience slow or rapid deterioration. The gut-joint axis represents a bidirectional relationship in OA onset and progression. This study aimed to establish and validate a prediction model of knee OA disease progression.

Enterprise stents versus low-profile visualized intraluminal support stents for stent-assisted coiling of unruptured paraclinoid aneurysms.

Background: The microsurgical treatment of paraclinoid aneurysms can be challenging due to the anatomical structures that surround them.

Objective: This study compared the clinical and angiographic outcomes of unruptured paraclinoid aneurysms treated with enterprise (EP) stents and low-profile visualized intraluminal support (LVIS) stents.

Methods: A retrospective analysis of the clinical and radiological data from 133 patients with 139 unruptured paraclinoid aneurysms, who received an EP or an LVIS stent between January 2017 and June 2021 at Taizhou People's Hospital, was performed.

Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats.

Glutamate excitotoxicity has been implicated in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). Synaptosome associated protein 23 (SNAP23) and SNAP25 are respectively participate in presynaptic glutamate release and postsynaptic glutamate receptor (NMDA receptor) trafficking, both of which are essential for glutamate-mediated excitatory toxicity. SNAP23 and SNAP25 exhibit high homology and SNAP23 has been shown to interact with Annexin A7 (ANXA7).