Acute coronary syndrome management in hemophiliacs: How to maintain balance?: A review.

To analyze existing literature and understand how to balance the minimization of bleeding risk and ensuring adequate anticoagulation during coronary intervention treatment and long-term postoperative anticoagulation in hemophilia patients during the perioperative period, in order to provide guidance for healthcare professionals in developing effective treatment plans. This narrative review will analyze existing studies, case reports, and clinical guidelines to determine the most effective strategies for managing acute coronary syndrome in hemophilia patients. When evaluating the literature, factors such as patient age, medical history, and severity of the condition will be considered.

miR-20b-5p attenuates hypoxia-induced apoptosis in cardiomyocytes via the HIF-1α/NF-κB pathway.

Chronic hypoxia is a common inducer of end-stage cardiovascular disease. In cells under hypoxia, the hypoxia-inducible factor-1 (HIF-1) plays a vital role in regulating downstream target genes. However, the mechanism of hypoxia in cardiomyocytes is still unclear.

Electrophysiologic characteristics of the Crista terminalis and implications on atrial tachycardia in rabbits.

The objective of this study was to evaluate the electrophysiologic characteristics of Crista terminalis (CT) and their implication in the pathogenesis of atrial tachycardia in rabbits. For this purpose, 27 New Zealand rabbits were used. Using standard glass microelectrode technique, cellular action potentials (APs) of CT and pectinate muscle (PM) were recorded in normal Tyrode's perfusion and Tyrode's perfusion with 4 μM isoproterenol.

Digitalis does not improve left atrial mechanical dysfunction after successful electrical cardioversion of chronic atrial fibrillation.

This study was designed to investigate whether administration of digitalis could improve mechanical function of left atrial appendage (LAA) and left atrium prospectively in patients with atrial stunning. Fifty-four consecutive patients in whom atrial stunning was observed immediately after cardioversion of chronic atrial fibrillation (AF) were randomized into digitalis or control group for 1 week following cardioversion. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) were performed prior to, immediately following, 1 day after and 1 week after cardioversion to measure transmitral flow velocity and LAA flow velocity.

[The role of coronary sinus musculature on electrical conduction between left atrium and right atrium in isolated canine heart].

Objective: To investigate electrophysiological characteristics of the coronary sinus musculature and explore its role on electrical conduction between left atrium and right atrium in isolated canine heart.

Method: The electrical connections between coronary sinus, left atrium and right atrium were detected by programmed stimulation delivered at coronary sinus ostium, distal coronary sinus and lateral wall of left atrium in a Langendorff model of canine.

Results: During stimulation delivered at coronary sinus ostium and distal coronary sinus, posterior wall of left atrium was firstly activated by electronic signal through coronary sinus musculature, the conduct time of coronary sinus ostium stimulation and distal coronary sinus stimulation were (44 +/- 21) ms and (41 +/- 15) ms, respectively.

Predictors of left atrial appendage stunning after electrical cardioversion of non-valvular atrial fibrillation.

Objective: To identify predictors of left atrial appendage stunning after the use of electrical cardioversion to restore sinus rhythm in patients with non-valvular atrial fibrillation.

Methods: A total of 68 consecutive patients (45 men, 23 women, 60.5 +/- 8.