Publications by authors named "Shanila Fernandez-Patel"
Article Synopsis
- - The study investigates multiple synchronous lung cancers (MSLCs) by analyzing samples from 8 patients using advanced sequencing methods to understand their genetic and immune differences across various stages.
- - Findings reveal that the tumors are clonally independent with shared driver mutations, but exhibit few common mutations between tumors from the same patient, indicating they developed independently.
- - The research highlights a shift in T cell profiles from pre-invasive to invasive adenocarcinoma, with an increase in regulatory T cells and exhausted CD8 T cells, as well as greater neoantigen diversity, emphasizing the unique genomic and immune traits of MSLCs.
This work highlights the development of a conductive elastomer (CE) based electrophoretic platform that enables the transfer of charged molecules from a solid-state CE electrode directly to targeted tissues. Using an elastomer-based electrode containing poly (3,4-ethylenedioxythiophene) nanowires, controlled electrophoretic delivery of methylene blue (MB) and fluorescein (FLSC) was achieved with applied voltage. Electroactive release of positively charged MB and negatively charged FLSC achieved 33.
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