In the present study, tyrosol-functionalized chitosan gold nanoparticles (Chi-TY-AuNPs) were prepared as an alternative treatment strategy to combat fungal infections. Various biophysical techniques were used to characterize the synthesized Chi-TY-AuNPs. The antifungal and antibiofilm activities of Chi-TY-AuNPs were evaluated against and , and efforts have been made to elucidate the possible mechanism of action.
View Article and Find Full Text PDFCarbon dots (C-dots), a promising luminescent nanomaterial with exceptional physico-chemical properties gaining enormous attention in recent years. Carbon dots having enhanced biocompatibility and multiple routes of synthesis offers a promising substitute to luminescent quantum dots (QD). Further, wavelength-controlled emission features of C-dots proved as a good candidate in the biolabeling applications.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
July 2020
The systematic studies of chromone appended novel chemosensors, favored to Mg ion detection, these were analyzed and characterized by different spectroscopic techniques such as NMR, mass spectroscopy, FTIR and optical techniques. The binding demeanor of the ligands was executed with the library of metal ions and shown the good coordination with Mg ion to the ligand's cavity. Both ligands demonstrated good binding behavior with Mg ion.
View Article and Find Full Text PDFBeilstein J Nanotechnol
September 2018
In the past few decades, the successful theranostic application of nanomaterials in drug delivery systems has significantly improved the antineoplastic potency of conventional anticancer therapy. Several mechanistic advantages of nanomaterials, such as enhanced permeability, retention, and low toxicity, as well as surface engineering with targeting moieties, can be used as a tool in enhancing the therapeutic efficacy of current approaches. Inorganic calcium phosphate nanoparticles have the potential to increase the therapeutic potential of antiproliferative drugs due to their excellent loading efficiency, biodegradable nature and controlled-release behaviour.
View Article and Find Full Text PDFMagnetic nanoparticles (MNPs) have the potency to deliver cancer drugs assisted by the application of a magnetic field. In this paper, we present the design of magnesium ferrite nanoparticles of size suitable for drug delivery. A coating polymer, poly(vinyl alcohol), tethered with a tapered cone-shaped cyclic oligosachcharide, β-cyclodextrin (β-CD) is synthesized and used to wrap and disperse the MNPs.
View Article and Find Full Text PDFMultifunctional novel core-shell composites, CdSNPs@ZIF-8, have been synthesized by in situ encapsulation of different amounts of CdSNPs (150, 300, and 500 μL suspension of CdSNPs in methanol) in ZIF-8 at room temperature. These composites have been characterized by powder X-ray diffraction, X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy, high-resolution transmission electron microscopy (HRTEM), and diffuse reflectance spectroscopy techniques and Brunauer-Emmett-Teller surface analysis. XPS and HRTEM indicate the encapsulation of CdSNPs within ZIF-8 crystal without disturbing the crystal order of ZIF-8.
View Article and Find Full Text PDFEarly detection is the critical phase in the prognostic strategy of various life-threatening maladies like infectious diseases and cancer. The mortality rate caused by these diseases could be considerably reduced if they were diagnosed in the early stages of disease development. Carbon dots (C-dots), a relatively new and promising candidate in the fluorescent nanomaterial category, possess a perceptible impact on various bioapplications.
View Article and Find Full Text PDFThe fabrication of polymeric nanofibers and its potential versatility instigated to foster smart hybrid nanomaterials for the removal of environmental pollutants. In this pursuit, in this research work, polyacrylonitrile (PAN)-based two-dimensional (2D) nanofibrous mats with polyethyleneimine (PEI)/Fe and quaternary ammonium (QA)/Fe as hybrid fillers were prepared by the electrospinning process for the effective dye removal and bacterial disinfection. The characteristics of the fabricated nanomaterials were extensively explored by several analytical techniques such as field emission-scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and Brunauer-Emmett-Teller analysis.
View Article and Find Full Text PDFChitosan nanoparticles can advance the pharmacological and therapeutic properties of chemotherapeutic agents by controlling release rates and targeted delivery process, which eliminates the limitations of conventional anti-cancer therapies and they are also safe as well as cost-effective. The aim of present study is to explore the anti-tumour effect of niclosamide in lung and breast cancer cell lines using biocompatible and biodegradable carrier where nanoparticles loaded with hydrophobic drug (niclosamide) were synthesized, characterized and applied as a stable anti-cancer agent. Niclosamide loaded chitosan nanoparticles (Nic-Chi Np's) of size approximately 100-120 nm in diameter containing hydrophobic anti-cancer drug, i.
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