Publications by authors named "Shangzhu Zhang"
Article Synopsis
- - The study aimed to evaluate the effectiveness and safety of ivarmacitinib, a JAK 1 inhibitor, in patients with moderate-to-severe rheumatoid arthritis (RA) who did not respond adequately to standard treatments.
- - Participants were divided into three groups to receive either placebo, ivarmacitinib 4 mg, or 8 mg once daily, with primary outcomes measured after 24 weeks based on 20% improvement in RA symptoms (ACR20).
- - Results showed significantly higher improvement rates in those taking ivarmacitinib compared to placebo, with manageable safety concerns, indicating it could be a promising option for this patient population.
Article Synopsis
- - The study examined 9 patients with Systemic Lupus Erythematosus (SLE) who also had Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyradiculoneuritis (CIDP), analyzing their clinical characteristics and outcomes over a 17-year period.
- - Among the patients, 6 had SLE with GBS and 3 had SLE with CIDP, with common symptoms including limb weakness and neurological issues like dysphagia and facial nerve palsy.
- - Treatments included glucocorticoids, immunoglobulin therapy, and other immunosuppressants, leading to varied outcomes, highlighting the importance of proper diagnosis and treatment approaches in SLE-related
Background: Serologically active clinically quiescent (SACQ) is a state within systemic lupus erythematosus (SLE) characterized by elevated serologic markers without clinical activity. The heterogeneity in SACQ patients poses challenges in disease management. This multicenter prospective study aimed to identify distinct SACQ subgroups and assess their utility in predicting organ damage.
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- This study investigates how anti-nucleosome antibodies impact organ damage in patients with Systemic Lupus Erythematosus (SLE), highlighting their importance alongside anti-dsDNA antibodies.
- Among 2,481 SLE patients, a significant percentage showed positive anti-nucleosome antibodies, with higher rates of lupus nephritis and new organ damage over an average follow-up of 4.31 years.
- The findings suggest that both antibody types are independent predictors of renal damage, and their combination may enhance the accuracy of predicting organ damage in SLE patients.
Objectives: This study explores the clinical characteristics associated with the occurrence of acute anterior uveitis (AAU) in patients with axial spondyloarthritis (axSpA) within a large, multicentre database.
Methods: This observational, cross-sectional study of patients with axSpA used data from the Chinese Spondyloarthritis Registry between August 1, 2018, and March 31, 2020. The demographic and clinical features of patients with and without AAU were compared.
Introduction: Early detection of neuropsychiatric systemic lupus erythematosus (NPSLE) remains a challenge in clinical settings. Previous studies have found different autoantibodies as markers for NPSLE. This study aimed to describe the distribution of psychiatric syndromes in a group of patients with systemic lupus erythematosus (SLE) and to investigate the association between psychiatric syndromes and specific autoantibodies.
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- The study aimed to explore how antiphospholipid antibodies (aPLs) affect the severity and prognosis of thrombocytopenia in patients with systemic lupus erythematosus (SLE).
- Researchers analyzed data from 350 SLE-TP patients, finding that those with aPLs had significantly lower platelet counts and a higher incidence of moderate to severe cases compared to those without aPLs.
- Patients with aPLs also experienced higher relapse rates and lower rates of achieving complete response during follow-up, indicating a more severe disease trajectory associated with the presence of aPLs.
Introduction: Anemia and malnutrition are recognized indicators of suboptimal physical condition in chronic inflammatory diseases. This study aimed to examine the association between anemia, low body mass index (BMI), and clinical outcomes in axial spondyloarthritis (axSpA).
Method: This cross-sectional analysis utilized data from the multicenter ChinaSpA cohort.
Introduction: We aimed to evaluate the risk factors for the development of deep vein thrombosis (DVT) within one month after delivery in pregnant women of advanced maternal age undergoing cesarean section and explore the predictive value of fasting coagulation indicators in relation to the development of DVT.
Methods: A total of 176 eligible postpartum women were included in this study. Sixty-seven cases developed DVT within one month after delivery (DVT group), while 109 cases did not experience DVT (NDVT group).
Background: Janus kinase (JAK) inhibitors have been proven to be effective and safe in various autoimmune diseases. However, there is still a lack of comprehensive evidence regarding their efficacy and safety in systemic and cutaneous lupus erythematosus.
Methods: We searched for systemic and cutaneous lupus erythematosus patients who were treated with JAK inhibitors in PubMed, Embase, Web of Science, and the Cochrane Library until February 28, 2023.
Article Synopsis
- This study checked how mental health issues relate to patients with a disease called systemic lupus erythematosus (SLE) and if treating those issues affects survival.
- Out of 160 patients looked at, a big majority (86.3%) had at least one mental health problem, with delirium being the most common.
- It was found that using antipsychotic medicine might help reduce the risk of death in these patients, so getting help for mental health problems early is important.
Objective: To evaluate the efficacy and safety of telitacicept in adult patients with primary SS (pSS) in a phase II randomized double-blind placebo-controlled trial.
Methods: Patients with pSS with positive anti-SSA antibody and ESSDAI ≥ 5 were randomly assigned, in a 1:1:1 ratio, to receive weekly subcutaneous telitacicept 240 mg, 160 mg, or placebo for 24 weeks. The primary end point was the change from baseline in the ESSDAI at week 24.
Article Synopsis
- The study examined clinical characteristics of Chinese patients with psoriatic arthritis (PsA) and whether having a family history of psoriasis/PsA influenced these characteristics.
- Out of 1074 patients, 29.1% had a family history, and these patients exhibited an earlier onset of symptoms, higher instances of certain complications (like enthesitis and nail involvement), and a greater prevalence of the HLA-B27 gene.
- The research is significant as it's the first nationwide study in China exploring how a family history of psoriatic disease affects clinical features in patients with PsA.
Objectives: To investigate potential predictors of treatment response in primary Sjögren's syndrome (pSS) patients with severe immune thrombocytopenia (ITP), with a focus on bone marrow megakaryocyte (MK) count.
Methods: This case-control study included patients with pSS and severe ITP who were admitted to Peking Union Medical College Hospital and met the 2002 AECG or 2016 American College of Rheumatology / European League Against Rheumatism criteria for SS. Patients who had overlap other connective tissue diseases and with thrombocytopenia that could be explained by other causes were excluded.
Background: Avascular necrosis is a common organ damage in SLE patients, which can influence patients' life quality. Conflicting results exist in risk factors of AVN in SLE patients. The aim of this study was to illustrate risk factors predicting the occurrence of avascular necrosis (AVN), also known as osteonecrosis, in systemic lupus erythematosus (SLE) patients in Chinese SLE Treatment and Research Group (CSTAR), a multi-center cohort of Chinese SLE patients.
View Article and Find Full Text PDFObjective: The pilot study aims to evaluate the effectiveness and safety of baricitinib in Behcet's Disease (BD) patients with refractory vascular involvement.
Methods: We consecutively enrolled vascular/cardiac BD patients who received baricitinib (2 mg/day) along with glucocorticoids (GCs) and immunosuppressants in our center. Efficacy assessment mainly depends on the proportion of clinical remission and side effects were recorded.
Objectives: This study aimed to investigate the clinical characteristics, outcomes, and associated factors of patients with systemic lupus erythematosus-associated diffusive alveolar hemorrhage (SLE-DAH) stratified by infection status in a national representative cohort.
Methods: This single-center retrospective study included 124 consecutive patients with SLE-DAH in a tertiary care center between 2006 and 2021. The diagnosis of DAH was made based on a comprehensive evaluation of clinical manifestations, laboratory and radiologic findings, and bronchoalveolar lavage.
Objective: This study aims to investigate clinical characteristics, potential risk factors, as well as long-term outcome in EGPA patients with GI involvement.
Methods: A total of 94 EGPA patients were included in this cohort study. We retrospectively reviewed the clinical data, treatment, and outcome of 21 EGPA patients with GI involvement and compared them with other 73 EGPA patients without GI involvement.
Article Synopsis
- Researchers studied 148 patients with polyarteritis nodosa (PAN) to find risk factors related to digital gangrene, noting that 31.8% of patients had this complication.
- Significant risk factors for digital gangrene included current smoking, elevated eosinophils, and high white blood cell counts, with 68.1% of affected patients undergoing specific pulse therapy.
- Poor prognosis was linked to high levels of serum C-reactive protein (CRP), highlighting its importance for patient monitoring and treatment outcomes.
Neuropsychiatric systemic lupus erythematosus (NPSLE) has a broad spectrum of subtypes with diverse severities and prognoses. Ischemic and inflammatory mechanisms, including autoantibodies and cytokine-mediated pathological processes, are key components of the pathogenesis of NPSLE. Additional brain-intrinsic elements (such as the brain barrier and resident microglia) are also important facilitators of NPSLE.
View Article and Find Full Text PDFBackground Synovial hypoxia is a hallmark of rheumatoid arthritis (RA). Photoacoustic (PA) imaging, based on the use of laser-generated US, can detect the oxygenation status of tissue in individuals with RA. However, large studies are lacking, with few investigating the correlation between oxygenation status and disease activity.
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- The review focuses on recent findings related to the spectrum of spondyloarthritis (SpA) in China, highlighting advancements in epidemiology, genetics, and treatment.
- The prevalence of ankylosing spondylitis (AS) in China ranges from 0.20-0.42%, with the majority of AS patients having the HLA-B27 antigen, particularly the HLA-B*2704 subtype.
- New treatment protocols involving tumor necrosis factor inhibitors and IL-17A inhibitors are effective for AS patients, but only a small percentage of patients with psoriatic arthritis receive biological agents.
Objectives: It is currently accepted that inflammation plays an important role in the pathogenesis of connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH). However, the efficacy of immunosuppressive therapy remains anecdotal. The objective of this systematic review was to evaluate the efficacy of immunosuppressive therapy in patients with CTD-PAH and to further assess whether response differs between CTD subtypes and clinical features.
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