Publications by authors named "Shangyan Hei"
Backgrounds: Ferroptosis is a form of regulated cell death. The accumulation of iron in the brain is linked to trigger ferroptosis after an ischaemic stroke (IS). Naoqing formula (NQ) is a traditional Chinese medicine metabolites with the clinical function of activating blood circulation, which is applied to treat IS clinically in China.
View Article and Find Full Text PDFAlzheimer's disease (AD) is the most common type of dementia with an insidious onset and slow progression. Kai-Xin-San (KXS) has been reported to be effective in improving cognitive impairment in AD. However, the mechanism is still confused.
View Article and Find Full Text PDFFibroblast is the critical repair cell for urethral wound healing. The dysfunction of fibroblasts can lead to excessive fibrosis and hypertrophic scar, which eventually leads to post-traumatic urethral stricture. However, the fibroblast subpopulation and intercellular communication in urethral stricture remains poorly understood.
View Article and Find Full Text PDFIntroduction And Hypothesis: There is currently no effective treatment for interstitial cystitis / bladder pain syndrome (IC/BPS) and thus seriously reduces the quality of life of patients. The purpose of this study is to analyze the structure and function of G protein coupled receptors related to IC/BPS by integrating bioinformatics and provide basis for the development of new drugs for IC/BPS.
Methods: We used ProtParam and DNAMAN to analyze the physical and chemical properties of GPR18 and GPR183 proteins.
Kai Xin San (KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this study, 72 specific-pathogen-free male Kunming mice aged 8 weeks were randomly divided into a vehicle control group, scopolamine group, low-dose KXS group, moderate-dose KXS group, high-dose KXS group, and positive control group. Except for the vehicle control group and scopolamine groups (which received physiological saline), the doses of KXS (0.
View Article and Find Full Text PDFArticle Synopsis
- Xingnaojing injection (XNJ) and Naloxone hydrochloride injection (NX) are used together to enhance consciousness and improve outcomes in patients with intracerebral hemorrhage (ICH), showing advantages over using NX alone.
- A systematic review of 32 randomized controlled trials (RCTs) indicated that the combination therapy significantly improves clinical efficacy, GCS scores, and other health metrics, but the quality of the studies was deemed low.
- Despite promising results, the overall effectiveness and safety of XNJ combined with NX remain inconclusive due to concerns like publication bias and variability in study quality, necessitating more rigorous research.
Meta-analysis of the efficacy of modafinil versus placebo in the treatment of multiple sclerosis fatigue.
Mult Scler Relat Disord
January 2018
Background: Clinical trials examining the therapeutic benefit of modafinil in MS fatigue provide conflicting data. The goal of this study was to systematically evaluate the efficacy of modafinil using a meta-analytic method.
Methods: A systematic literature search was performed on published peer reviewed articles from 2000 to 2017 using the Cochrane Library, PubMed, and EMBASE.