Publications by authors named "Shangkun Zhao"
Background: Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic disease with a high disability rate. Long-term administration of steroids is the most common pathogenic factor for non-traumatic ONFH. Early diagnosis of steroid-induced osteonecrosis of the femoral head (SONFH) is difficult and mainly depends on imaging.
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- - The senescence-associated secretory phenotype (SASP) is when old or damaged cells release certain substances that can help with tissue repair but can also cause problems, especially in healing fractures.
- - Some drugs called senolytics can get rid of these old cells, which might help improve healing from fractures and other aging issues.
- - Researchers are studying how SASP affects fracture healing to find better treatments, and they are also testing these senolytics to see how well they work in real-life situations.
Few reports in the literature describe the treatment experience of benign lesions of the femoral head and neck. Between July 2005 and August 2009, twenty-four patients with bone tumor of the femoral neck and head were treated at the authors' institution. Fourteen patients had pathological fractures of the femoral neck; in the other 10 patients, the bone cortex was involved.
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