Publications by authors named "Shangjiu Yang"
Purpose: Procollagen C-proteinase enhancer 1 (PCPE-1) is associated with liver fibrosis, a major risk factor of hepatocellular carcinoma (HCC). However, its role in HCC remains unclear.
Materials And Methods: The mRNA and protein expression levels of PCPE-1 were analyzed using publicly available datasets of HCC tissues and matched normal tissues.
Article Synopsis
- RNA methylation plays a crucial role in tumor progression, yet its specific influence on microsatellite instability (MSI) in colorectal cancer (CRC) is not fully understood, prompting further investigation.
- This study analyzed the impact of RNA methylation-related genes on patient outcomes and immunotherapy responses in CRC patients with low (MSI-L) or stable (MSS) microsatellite instability, comparing them to those with high instability (MSI-H).
- The research developed an MSI-RMscore to predict patient risks and outcomes, revealing that a high-risk group had poorer survival and lower immunotherapy effectiveness, while highlighting the potential of INHBB and SOWAHA as therapeutic targets to improve treatment responses.