Publications by authors named "Shangdi Wu"

Polydopamine (PDA) is a widely utilized photothermal conversion material recognized for its ease of synthesis and environmental friendliness. However, its relatively weak light absorption capabilities lead to lower photothermal efficiency, restricting its application in solar steam generation (STG) processes. To effectively enhance light absorption, this study introduces a deep co-deposition method for the microstructural design of STG membranes.

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Surgical coaching has been proven to effectively enhance clinical performance. However, diverse implementation strategies present challenges when initiating new programs. Our scoping review aimed to synthesize the existing literature on surgical coaching, thereby informing the direction of future coaching initiatives.

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Background: Iatrogenic bile duct injuries (BDIs) prevention during laparoscopic cholecystectomy (LC) relies on meticulous anatomical dissections through direct visualization. Near-infrared fluorescence (NIRF) with indocyanine green (ICG) improves the visualization of extrahepatic biliary structures. Although ICG can be administered either intravenously or intragallbladder, there remains uncertainty regarding the optimal method for different patient populations.

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Article Synopsis
  • PDAC (Pancreatic ductal adenocarcinoma) has a poor prognosis mainly due to metastasis, and the study investigates the role of PLEK2, identified as an oncogene in various tumors, on PDAC progression.
  • Expression analysis showed that high levels of PLEK2 in tumor specimens correlate with poorer patient survival and advanced cancer stages, while functional assays demonstrated that PLEK2 enhances PDAC cell migration and invasion.
  • The findings suggest PLEK2's potential as a therapeutic target, linking its activity to increased tumor growth and specific molecular pathways, including MMP1 regulation and activation of signaling proteins like p-ERK and p-STAT3.
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There is a significant difference in prognosis and response to chemotherapy between basal and classical subtypes of pancreatic ductal adenocarcinoma (PDAC). Further biomarkers are required to identify subtypes of PDAC. We selected candidate biomarkers via review articles.

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Article Synopsis
  • Laparoscopic cholecystectomy (LC) is the best method for treating gallstones but poses risks like bile duct injury (BDI); implementing the Critical View of Safety (CVS) approach could reduce these risks, yet its practical use is still low due to performance variations among surgeons.
  • The study tested an AI-assisted coaching program called SmartCoach in a randomized trial from May 2022 to August 2023, comparing the performance of novice surgeons who received AI feedback versus those who learned independently, with performance measured using the Laparoscopic Cholecystectomy Rating Form (LCRF).
  • Results indicated that surgeons in the AI coaching group significantly improved their LCRF scores over time and achieved better CVS
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Pancreatic ductal adenocarcinoma (PDAC) is not sensitive to most chemotherapy drugs, leading to poor chemotherapy efficacy. Recently, Trametinib and Palbociclib have promising prospects in the treatment of pancreatic cancer. This article aims to explore the effects of Trametinib on pancreatic cancer and address the underlying mechanism of resistance as well as its reversal strategies.

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Intra-abdominal adhesions have consistently posed a challenge for surgeons during procedures. This study aims to investigate the feasibility of utilizing indocyanine green (ICG) in conjunction with near-infrared imaging for the detection of intra-abdominal adhesions. In vitro, we analyzed factors affecting ICG fluorescence.

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Background: The rate of bile duct injury in laparoscopic cholecystectomy (LC) continues to be high due to low critical view of safety (CVS) achievement and the absence of an effective quality control system. The development of an intelligent system enables the automatic quality control of LC surgery and, eventually, the mitigation of bile duct injury. This study aims to develop an intelligent surgical quality control system for LC and using the system to evaluate LC videos and investigate factors associated with CVS achievement.

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Background: Laparoscopic radical antegrade modular pancreatosplenectomy (L-RAMPS) has not been widely performed due to its technical challenging. We introduce a novel approach, named "Plane first" approach, for L-RAMPS in this study.

Methods: From January 2015 to August 2021, we performed 51 cases of L-RAMPS.

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Background: Due to varied surgical skills and the lack of an efficient rating system, we developed Surgesture based on elementary functional surgical gestures performed by surgeons, which could serve as objective metrics to evaluate surgical performance in laparoscopic cholecystectomy (LC).

Methods: We defined 14 LC basic Surgestures. Four surgeons annotated Surgestures among LC videos performed by experts and novices.

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Background: Artificial intelligence and computer vision have revolutionized laparoscopic surgical video analysis. However, there is no multi-center study focused on deep learning-based laparoscopic cholecystectomy phases recognizing. This work aims to apply artificial intelligence in recognizing and analyzing phases in laparoscopic cholecystectomy videos from multiple centers.

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As an environmentally friendly and promising semiconductor, graphitic carbon nitride (g-CN) was widely used in photocatalytic treatment of aqueous organic pollutants. In this study, cobalt-to-oxygen doped graphitic carbon nitride with feeble nitrogen vacancies (Co-OCN) as metal-to-ligand charge transfer was synthesized via a facile thermal polymerization method with low cost and non-toxic precursors. The oxygen doped graphitic carbon nitride with feeble nitrogen vacancies (OCN) ligand was successfully formed and cobalt was presented in OCN in an ionic form (in the form of Co-N).

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