Nanomorphogenesis of interlayered polyamide membranes for precise ion sieving in lithium extraction.

Nanofiltration (NF) offers a scalable and energy-efficient method for lithium extraction from salt lakes. However, the selective separation of lithium from magnesium, particularly in brines with high magnesium concentrations, remains a significant challenge due to the close similarity in their hydrated ionic radii. The limited Li/Mgselectivity of current NF membranes is primarily attributed to insufficient control over pore size and surface charge.

The application of ERAS in pilonidal sinus: comparison of postoperative recovery between primary suture and Limberg flap procedure in a multicenter prospective randomized trial.

Purpose: We evaluated the clinical effect of utilizing a Limberg rhomboid flap graft in conjunction with Enhanced Recovery After Surgery (ERAS) protocols for the management of pilonidal sinus in the sacrococcygeal region to demonstrate the feasibility of applying ERAS to the treatment of pilonidal sinus.

Methods: Between January 2010 and August 2018, prospective data analysis was undertaken on 109 patients who received surgical treatment for pilonidal sinus in the sacrococcygeal region at the Department of Colorectal and Anal Surgery, Jingzhou Hospital affiliated to Yangtze University, and Taizhou Affiliated Hospital of Nanjing University of Chinese Medicine. The patients were randomly separated into two groups based onoperation technique: the control group (pilonidal sinus resection with primary suture) and the observation group (pilonidal sinus resection with Limberg flap graft).

Characterization and Genome Analysis of the Delftia lacustris Strain LzhVag01 Isolated from Vaginal Discharge.

Delftia has been separated from freshwater, sludge, and soil and has emerged as a novel opportunistic pathogen in the female vagina. However, the genomic characteristics, pathogenicity, and biotechnological properties still need to be comprehensively investigated. In this study, a Delftia strain was isolated from the vaginal discharge of a 43-year-old female with histologically confirmed cervical intraepithelial neoplasm (CIN III), followed by whole-genome sequencing.

biofilm formation of and associated with bacterial vaginosis and aerobic vaginitis.

Objective: To determine the optimum biofilm formation ratio of () in a mixed culture with ().

Methods: ATCC14018, ATCC25922, as well as five strains of were selected from the vaginal sources of patients whose biofilm forming capacity was determined by the Crystal Violet method. The biofilm forming capacity of in anaerobic and non-anaerobic environments were compared using the identical assay.

Node-Aligned Graph-to-Graph: Elevating Template-free Deep Learning Approaches in Single-Step Retrosynthesis.

Single-step retrosynthesis in organic chemistry increasingly benefits from deep learning (DL) techniques in computer-aided synthesis design. While template-free DL models are flexible and promising for retrosynthesis prediction, they often ignore vital 2D molecular information and struggle with atom alignment for node generation, resulting in lower performance compared to the template-based and semi-template-based methods. To address these issues, we introduce node-aligned graph-to-graph (NAG2G), a transformer-based template-free DL model.

Feasibility and safety of specimen extraction an enlarged (U-Plus) skin bridge loop ileostomy: a single-center retrospective comparative study.

Objective: To investigate the feasibility and safety of specimen extraction an enlarged (U-Plus) skin bridge loop ileostomy.

Methods: A retrospective analysis of 95 patients with rectal cancer who underwent laparoscopic low anterior rectal resection and skin bridge loop ileostomy between August 2018 and August 2022, including 44 patients with specimen extraction an enlarged (U-Plus) skin bridge loop ileostomy (experimental group) and 51 patients with specimen extraction an abdominal incision (control group). Following the application of propensity score matching (PSM), 34 pairs of data were successfully matched.

Bioinspired Fast Room-Temperature Self-Healing, Robust, Adhesive, and AIE Fluorescent Waterborne Polyurethane via Hierarchical Hydrogen Bonds and Use as a Strain Sensor.

Developing a new generation of ecofriendly water-based polymeric materials that integrate mechanical robustness, fast room-temperature self-healing, adhesive, and fluorescence remains a formidable challenge. Herein, inspired by titin protein, a series of novel waterborne polyurethanes (WPU-CHZ-NAGA) containing irregular 6-fold and diamide hydrogen bonds are synthesized by introducing carbohydrazide (CHZ) and ,-bis(2-hydroxyethyl)-3-amino propionyl glycinamide (HO-NAGA-OH) groups. The representative WPU-CHZ-NAGA exhibits outstanding mechanical properties (tensile strength of 36.

Physalin A Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Inhibition of PI3K/Akt Signaling Pathway.

Physalin A (PA) is a bioactive withanolide with multiple pharmacological properties and has been indicated to be cytotoxic to hepatocellular carcinoma (HCC) cell line HepG2. This study aims to explore the mechanisms underlying PA antitumor activity in HCC. HepG2 cells were exposed to various concentrations of PA.

[Effect of needle-knife on chondrocyte apoptosis of knee joint in rabbits with knee osteoarthritis based on CircSERPINE2-miR-1271-5P-ERG axis].

Objective: To observe the effect of needle-knife on the chondrocyte apoptosis of knee joint in rabbits with knee osteoarthritis (KOA) based on the CircSERPINE2-miR-1271-5P-E26 specific transformation-related gene (ERG) axis, and to explore the mechanism of needle-knife for KOA.

Methods: Thirty-six New Zealand white rabbits were randomly divided into a normal group, a model group, a needle-knife group and a sham needle-knife group, 9 rabbits in each group. The rabbits in the model group, the needle-knife group and the sham needle-knife group were treated with modified Videman method to prepare KOA model.

Flame-Retardant and Self-Healing Waterborne Polyurethane Based on Organic Selenium.

Waterborne polyurethane has drawn extensive attention due to its environmental friendliness and is widely used in many areas. However, it is still a great challenge to synthesize waterborne polyurethanes with flame retardancy and fast room-temperature self-healing ability, along with excellent mechanical performance and emulsion stability due to the mutually contradictory nature of these properties. Herein, waterborne polyurethanes containing organic selenium (SWPU-) from 0.

Application of laparoscopic modified Bacon operation in patients with low rectal cancer and analysis of the changes in anal function: A retrospective single-center study.

Purpose: To investigate the value of modified Bacon operation in patients with low rectal cancer.

Methods: Retrospective analysis of 60 patients treated with laparoscopic surgery for low rectal cancer in the Department of Colorectal and Anal Surgery, Jingzhou Hospital affiliated to Yangtze University, from 2019 to 2022, divided into observation and control groups based on the method of the operation (laparoscopic modified Bacon operation group and laparoscopic Dixon operation with prophylactic ileostomy group). We compared the variations between the two groups.

Mitigation of amplified spontaneous emission noise for an all-fiber coaxial aerosol lidar with different single-photon detectors.

For a coaxial single-photon lidar system, amplified spontaneous emission (ASE) noise from the fiber amplifier is inevitable. The ASE backscattering from specular reflection annihilates the far-field weak signal, resulting in low signal-to-noise ratio, short measurement distance, and even misidentification. We propose a method for calibrating and mitigating ASE noise in all-fiber coaxial aerosol lidar and demonstrate the method for a lidar system with different single-photon detectors (SPDs).

Liquid-Free Ion-Conducting Elastomer with Environmental Stability for Soft Sensing and Thermoelectric Generating.

Ionic conductors are promising candidates for fabricating soft electronics, but currently applied ionic hydrogels and organogels suffer from liquid leakage and evaporation issues. Herein, we fabricated a free-liquid ionic conducting elastomer (LFICE) with dry lithium bis(trifluoromethane sulfonimide) and elastomeric waterborne polyurethane. The resultant versatile LFICE exhibits superior tensile strength (∼4.

Redox-responsive carrier based on fluorinated gemini amphiphilic polymer for combinational cancer therapy.

Polymeric micelle has emerged as an efficient implement to overcome the shortcomings of conventional cancer chemotherapy due to its superior solubility of hydrophobic drugs and less side effects of drugs. However, insufficient dilution resistance and ordinary therapeutic effect severely restrict the further translation of current drug-loaded polymeric micelles. Here, we showed that well-defined G-Fn (n = 5, 9, 13) polymeric micelles possessed excellent capabilities as a drug carrier in light of high drug loading content, high stability and precise drug release combined with wonderful endocytosis efficiency to tumors.

Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage.

Aminoglycosides exhibit ototoxicity by damaging mitochondria, which in turn generate reactive oxygen species that induce hair cell death and subsequent hearing loss. It is well known that damaged mitochondria are degraded by mitophagy, an important mitochondrial quality control system that maintains mitochondrial homeostasis and ensures cell survival. However, it is unclear whether dysregulation of mitophagy contributes to aminoglycoside-induced hair cell injury.

Fetal Familial Cerebral Cavernous Malformation With a Novel Heterozygous Variation.

Background And Objectives: To identify fetal familial cerebral cavernous malformation (CCM) and a novel variation.

Methods: A 37-year-old pregnant woman (G4P0) presented with right-handed numbness since 2 weeks at 31 weeks of gestation. Evaluation with brain MRI revealed multiple CCMs.

The incidence of placenta related disease after the hysteroscopic adhesiolysis in patients with intrauterine adhesions.

Objective: To analyze the correlation between placenta related disease of pregnant women with antecedent hysteroscopic adhesiolysis due to intrauterine adhesions (IUA).

Materials And Methods: This is a single center, non-randomized, open-label, retrospective cohort Study. 74 patients who had adhesiolysis and hormone therapy for IUA and progressed into the third trimester were group A and 296 without IUA were group B.

Effect of Pd loading on ZrO support resulting from pyrolysis of UiO-66: Application to CO oxidation.

The effect of Pd loading (0.25, 0.5 and 1.

Comparison of therapeutic interventions for recurrent pregnancy loss in association with antiphospholipid syndrome: A systematic review and network meta-analysis.

Antiphospholipid syndrome (APS) is one of the treatable causes for pregnant women with recurrent pregnancy loss (RPL). This review compares the efficacy of a few treatment interventions (low-dose aspirin (LDA), aspirin plus low molecular weight heparin (LMWH), or unfractionated heparin (UFH)) in preventing complications during pregnancy and miscarriages for women with RPL and APS, and the potential differences in therapeutic effects of UFH and LMWH when combined with aspirin. We searched randomized controlled trials (RCTs) in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials and performed a systematic review and a Bayesian network meta-analysis (NMA).

A novel and nonderivatization method for the determination of valproic acid in human serum by two-dimensional liquid chromatography.

A novel and robust two-dimensional liquid chromatography with ultraviolet detection method (2D-LC-UV) was developed and validated for high-throughput determination of the concentrations of valproic acid (VPA) in human plasma. This 2D-LC system was composed of a first-dimensional LC column, a second-dimensional LC column and an intermediate transfer column. The sample was directly injected into the 2D-LC system after an easy protein precipitation treatment.

Estrogen therapy before hysteroscopic adhesiolysis improves the fertility outcome in patients with intrauterine adhesions.

Purposes: To describe the fertility outcomes after hysteroscopic adhesiolysis combined with preoperative hormone treatment in women with intrauterine adhesion (IUA).

Methods: This study is a retrospective cohort study. A total of 230 patients with IUA underwent hysteroscopic adhesiolysis combined with hormone treatment from Jan 2012 to Jun 2018.