Safety of longer linezolid regimen in children with drug-resistant tuberculosis and extensive tuberculosis in Southwest China.

Objectives: Linezolid (LNZ) has recently been listed by the World Health Organization (WHO) as a Group A agent for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in longer regimens (18-20 months). However, little is known about the safety of LNZ in longer TB treatment regimens in children.

Methods: Here we report 31 children who received LNZ treatment for drug-resistant tuberculosis (DR-TB) and extensive tuberculosis in the Children's Hospital of Chongqing Medical University, China, during September 2016 to March 2019.

Long non-coding RNA GAPLINC promotes angiogenesis by regulating miR-211 under hypoxia in human umbilical vein endothelial cells.

In this study, we investigated the role of a long non-coding RNA GAPLINC in angiogenesis using human umbilical vein endothelial cells (HUVEC). We found that hypoxia and hypoxia-inducible factor 1α (HIF-1α) increased the expression of GAPLINC in HUVEC cells. Moreover, GAPLINC overexpression down-regulated miR-211 and up-regulated Bcl2 protein expression.

Fast Gelation of Ti C T MXene Initiated by Metal Ions.

Gelation is an effective way to realize the self-assembly of nanomaterials into different macrostructures, and in a typical use, the gelation of graphene oxide (GO) produces various graphene-based carbon materials with different applications. However, the gelation of MXenes, another important type of 2D materials that have different surface chemistry from GO, is difficult to achieve. Here, the first gelation of MXenes in an aqueous dispersion that is initiated by divalent metal ions is reported, where the strong interaction between these ions and OH groups on the MXene surface plays a key role.

Pathophysiology of aged lymphatic vessels.

Lymphatic vessels maintain body homeostasis by recirculation of fluid and cells. Cell senescence induces lymphatic dysfunction. Impaired contractile function is caused by low muscle cell investiture and decrease of nitric oxide in aged lymphatic collectors, leading to poor drainage of lymph.

Packing Activated Carbons into Dense Graphene Network by Capillarity for High Volumetric Performance Supercapacitors.

Supercapacitors are increasingly in demand among energy storage devices. Due to their abundant porosity and low cost, activated carbons are the most promising electrode materials and have been commercialized in supercapacitors for many years. However, their low packing density leads to an unsatisfactory volumetric performance, which is a big obstacle for their practical use where a high volumetric energy density is necessary.

Novel mesoporous organosilica nanoparticles with ferrocene group for efficient removal of contaminants from wastewater.

Traditional method to functionalize mesoporous silica nanoparticles with organic groups for removal of contaminants from wastewater was surface modification. However, this surface modification could not cover the entire surface, leading to incomplete utilization of the high surface area of MSNs. In this work, we designed and prepared a novel inorganic-organic hybrid nanomaterial: ferrocene incorporated mesoporous organosilica nanoparticles (MONs).

Spin fluctuation induced Weyl semimetal state in the paramagnetic phase of EuCdAs.

Weyl fermions as emergent quasiparticles can arise in Weyl semimetals (WSMs) in which the energy bands are nondegenerate, resulting from inversion or time-reversal symmetry breaking. Nevertheless, experimental evidence for magnetically induced WSMs is scarce. Here, using photoemission spectroscopy, we observe that the degeneracy of Bloch bands is already lifted in the paramagnetic phase of EuCdAs.

The Performance of Super Absorbent Polymer (SAP) Water-Retaining Asphalt Mixture.

Lowering the temperature of the road surface is one efficient way to alleviate the urban heat island effect. Therefore water-retaining asphalt mixture was produced by adding super absorbent polymer (SAP) containing cement mortar to the porous asphalt mixture. In this study, the water absorption capacity, mechanical strength and fluidity of the cured water-retaining mortar were investigated to determine the optimum SAP dosage in water-retaining mortar.

A Single Center Experience of In Situ Needle Fenestration of Supra-aortic Branches During Thoracic Endovascular Aortic Repair.

Background: To report the early results and technical details of in situ needle fenestration during thoracic endovascular aortic repair (TEVAR).

Materials And Methods: Thirty-seven patients with thoracic aortic disease who underwent TEVAR with in situ needle fenestration in our department between February 2016 and April 2017 were included in this study. Their demographic information, clinical manifestations, periprocedural outcomes, and follow-up results were analyzed.

Photocatalytic 1,1-Hydrofluoroalkylation of Alkynes with a Concurrent Vicinal Acylation: An Access to Fluoroalkylated Cyclic Ketones.

A visible-light-induced 1,1-hydrofluoroalkylation of alkynes with a concomitant vicinal acylation is developed using tetrahydrofuran (THF) as the hydrogen atom source. Various fluoroalkylated cyclic ketones, such as indanones, chroman-4-ones, 2,3-dihydroquinolin-4(1 H)-ones, and 3,4-dihydronaphthalen-1(2 H)-ones, can be efficiently synthesized with excellent trans-diastereoselectivity. The reaction represents the first example of 1,1-hydrofluoroalkylation of alkynes, thus providing a novel method for the construction of fluoroalkanes.

Mid-Term Results of Endovascular Treatment for Spontaneous Isolated Dissection of the Superior Mesenteric Artery.

Objectives: Endovascular treatment (EVT) is an alternative method to treat spontaneous isolated dissection of the superior mesenteric artery (SIDSMA). Although its short-term results are promising, few mid-term results have been reported. This study reports the five year follow up of EVT for SIDSMA.

Hypoxia promotes differentiation of adipose-derived stem cells into endothelial cells through demethylation of ephrinB2.

Background: Delivery of endothelial cells into the ischemic tissue is emerging as an alternative approach in revascularization of injured tissues by means of angiogenesis to restore organ function. Adipose-derived stem cells (ASCs) are a readily accessible source of the mesenchymal stem cell with rapid expansion and multidifferentiation potential. The view has emerged that endothelial cells (ECs) differentiated from ASCs is a step forward for adult vascular repair in regenerative medicine and construction of the blood vessel by tissue engineering approach.

Renal Safety of Intra-Arterial Treatment after Acute Ischemic Stroke with Multimodal CT Imaging selection.

Background: Multimodal computed tomography imaging is used to identify eligible patients for intra-arterial treatment. A concern with this method is the multiple use of iodinated contrast material which presents a possible risk of renal toxicity. We compared the safety of intra-arterial treatment versus intravenous treatment during acute ischemic stroke treatment with a focus on renal safety.

[Recurrent Angelman syndrome caused by a rare partial deletion of UBE3A gene].

Objective: To provide genetic testing for two brothers with mental retardation and epilepsy.

Methods: Array comparative genomic hybridization (aCGH) was used to detect copy number variations in the two patients, their parents and maternal grandparents. Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) was utilized to delineate the deleted region in the pedigree.

Recent advances of 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) in photocatalytic transformations.

1,2,3,5-Tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) is a typical donor-acceptor fluorophore, with carbazolyl as an electron donor and dicyanobenzene as an electron acceptor. It has emerged as a powerful organophotocatalyst since 2016. Excellent redox window, good chemical stability and broad applicability make 4CzIPN an attractive metal-free photocatalyst.

An Albumin Biopassive Polyallylamine Film with Improved Blood Compatibility for Metal Devices.

Nowadays, a variety of materials are employed to make numerous medical devices, including metals, polymers, ceramics, and others. Blood-contact devices are one of the major classes of these medical devices, and they have been widely applied in clinical settings. Blood-contact devices usually need to have good mechanical properties to maintain clinical performance.

Laue three dimensional neutron diffraction.

This article presents a measurement technique and data analysis tool to perform 3D grain distribution mapping and indexing of oligocrystalline samples using neutrons: Laue three-dimensional neutron diffraction (Laue3DND). The approach builds on forward modelling used for correlation and multiple fitting of the measured diffraction spots relative to individual grains. This enables not only to identify individual grains, but also their position and orientation in the sample.

Bispecific anti-CD3 x anti-B7-H3 antibody mediates T cell cytotoxic ability to human melanoma in vitro and in vivo.

Inhibition of the B7-H3 immune checkpoint is reported to limit the tumor growth of B7-H3 tumors. In this study, we demonstrated B7-H3 expression in human melanoma cells, including a primary culture and several cell lines. Furthermore, we investigated whether B7-H3 could serve as a target for T cell-mediated immunotherapy against melanoma.

SFDR and gain enhancement in photonic downconversion link by linearization and full spectrum utilization.

In this work, an all-optical scheme to improve the gain and linearity of the downconverted analog photonic link is proposed and verified. We utilize the different electro-optic coefficients of the z-cut LiNbO phase modulator to realize the suppression of the third-order intermodulation distortion. On this basis, the link gain is improved by reusing optical carrier and lower sidebands.

Time-Reversal Symmetry Breaking in Re-Based Superconductors.

To trace the origin of time-reversal symmetry breaking (TRSB) in Re-based superconductors, we performed comparative muon-spin rotation and relaxation (μSR) studies of superconducting noncentrosymmetric Re_{0.82}Nb_{0.18} (T_{c}=8.

Network selection method based on MADM and VH-based multi-user access scheme for indoor VLC hybrid networks.

Recently, the visible light communication (VLC) based on LEDs has attracted much attention. In this paper, in order to realize multi-user wireless communication for VLC-based indoor hybrid networks, a network selection method based on Multi Attribute Decision Making (MADM) is proposed, which effectively combines the subjective preference of the user with the objective performance of each network. And then, a VH-based (virtual handover) multi-user access scheme is proposed, which considers different MAC and channel information.

Catechol/polyethyleneimine conversion coating with enhanced corrosion protection of magnesium alloys: potential applications for vascular implants.

Magnesium (Mg) alloys are promising biodegradable materials but challenges remain due to their rapid degradation, especially in the potential use of Mg alloys as vascular stents. Surface modification techniques are the most straightforward way to address both the desired biocompatibility and inhibit the corrosion of Mg alloys. In this work, inspired by the functional moieties (catechols) of mussel adhesive proteins, a mimetic approach to construct organic protective conversion coatings on magnesium-zinc-manganese (MgZnMn) alloys is investigated.

New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III.

Timosaponin B III is a major bioactive steroidal saponin isolated from Bge. To potentially discover derivatives with better biological activity, timosaponin B III was structurally modified via acid hydrolysis to yield one new (, timopregnane A I) C steroidal glycoside and seven known compounds. Their structures were elucidated on the basis of NMR spectroscopy and mass spectrometry.

Design of magnetic spirals in layered perovskites: Extending the stability range far beyond room temperature.

In insulating materials with ordered magnetic spiral phases, ferroelectricity can emerge owing to the breaking of inversion symmetry. This property is of both fundamental and practical interest, particularly with a view to exploiting it in low-power electronic devices. Advances toward technological applications have been hindered, however, by the relatively low ordering temperatures of most magnetic spiral phases, which rarely exceed 100 K.