A Multivalent mRNA Therapeutic Vaccine Exhibits Breakthroughs in Immune Tolerance and Virological Suppression of HBV by Stably Presenting the Pre-S Antigen on the Cell Membrane.

: In chronic hepatitis B infection (CHB), the hepatitis B surface antigen (HBsAg) continuously exhausts the hepatitis B surface antibody (HBsAb), which leads to the formation of immune tolerance. Accordingly, the hepatitis B virus (HBV) infection can be blocked by inhibiting the binding of the hepatitis B surface pre-S1/pre-S2 antigen to the hepatocyte receptor NTCP, but the clinical cure rate of pre-S-based vaccines for CHB is limited. : In this study, we designed and prepared multivalent hepatitis B therapeutic mRNA vaccines encoding three hepatitis B surface antigen proteins (L, M, and S) at the cell membrane, verified via in vitro transfection and expression experiments.

Gate-Tunable Short-Wave Infrared Polycrystalline GeSn Phototransistors on Noncrystalline Substrates.

GeSn is a group-IV alloy with immense potential to advance microelectronics technology due to its intrinsic compatibility with existing Si CMOS processes. With a sufficiently high Sn composition, GeSn is classified as a direct bandgap semiconductor. Polycrystalline GeSn holds several additional advantages, including its significantly lower synthesis cost compared to its epitaxial counterpart, as well as the versatility to grow these films on a variety of substrates.

Elucidating the size distribution of p‑Phenylenediamine-Derived quinones in atmospheric particles.

Transformed from p-phenylenediamines (PPDs) antioxidant, PPD-derived quinones (PPD-Qs) have recently been recognized as emerging contaminants due to their potential negative impacts on the environment and human health. While there have been measurements of airborne PPD-Qs, the size distribution of PPD-Qs and the impact of particle size on PPD transformation chemistry remain largely unknown. Here, through the measurements of atmospheric particles in three megacities in China (Beijing, Xi'an, and Hefei), we find that PPD-Qs are widely distributed in these cities.

π-Stacked organic heterojunction enabled efficient hydrogen peroxide photoproduction.

Hydrogen peroxide (HO) finds wide application in disinfection, chemical production, and bleaching owing to its sustainability and ease of storage compared to hydrogen. However, the current industrial engineering practices for producing photocatalysts used in HO generation face challenges such as low yields with organic catalysts and high costs associated with inorganic catalysts. In light of these challenges, we investigate a viable method utilizing a simple condensation reflux technique to synthesize pure organic heterojunction photocatalysts featuring a π-π stacked structure derived from graphitized carbon nitride (melem) and meso-tetrakis (4-carboxyphenyl) porphyrin, enabling efficient HO production without the necessity of sacrificial agents.

Solar-Driven Thermally Regenerative Electrochemical Cells for Continuous Power Generation with Coupled Optical and Thermal Integration.

This study presents the development of a solar-driven thermally regenerative electrochemical cell (STREC) for continuous power generation. Key innovations include dual-function carbon-based electrodes for efficient solar absorption and electrochemical reactions, a transparent and ultrainsulating silica aerogel to maximize solar spectrum transmission while minimizing heat loss, and a compact heat exchanger to recover heat from hot cell streams. Under 1 sun conditions, the STREC achieves a power density of 912.

Uncovering Emergent Spacetime Supersymmetry with Rydberg Atom Arrays.

In the zoo of emergent symmetries in quantum many-body physics, the previously unrealized emergent spacetime supersymmetry (SUSY) is particularly intriguing. Although it was known that spacetime SUSY could emerge at the (1+1)d tricritical Ising transition, an experimental realization is still absent. In this Letter, we propose to realize emergent spacetime SUSY using reconfigurable Rydberg atom arrays featuring two distinct sets of Rydberg excitations, tailored for implementation on dual-species platforms.

Associations between serum potassium variability and mortality in patients undergoing maintenance hemodialysis: a retrospective study.

Dyskalemia are associated with an increased risk of mortality in patients undergoing maintenance hemodialysis (MHD). However, studies evaluating the impact of serum potassium variability on mortality in MHD patients are scarce. To investigate serum potassium variability and its association with prognosis in MHD patients, we conducted a retrospective study on maintenance hemodialysis patients from three campus of Renji Hospital between June 2018 and December 2022.

Durable Antibacterial Photothermal Membrane Using Melanin-Inspired Cu-Doped Polynorepinephrine for Water Remediation.

Solar-driven interfacial evaporation is an efficient approach to addressing water scarcity due to its environmental sustainability. However, the prolonged use of solar evaporators causes microbial contamination from wastewater. Inspired by the antifouling properties of polydopamine, we develop a series of mono- and dual-metal-loaded poly(norepinephrine) (PNE) nanoparticles by pre-doping multiple metal ions.

Preoperative markers for identifying CT ≤2 cm solid nodules of lung adenocarcinoma based on image deep learning.

Background: The solid pattern is a highly malignant subtype of lung adenocarcinoma. In the current era of transitioning from lobectomy to sublobar resection for the surgical treatment of small lung cancers, preoperative identification of this subtype is highly important for patient surgical approach selection and long-term prognosis.

Methods: A total of 1489 patients with clinical stage IA1-2 primary lung adenocarcinoma were enrolled.

Single-cell multi-modal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma.

Background: Various epigenetic regulations systematically govern gene expression in cells involving various biological processes. Dysregulation of the epigenome leads to aberrant transcriptional programs and subsequently results in diseases, such as cancer. Therefore, comprehensive profiling epigenomics is essential for exploring the mechanisms underlying gene expression regulation during development and disease.

A Novel Intelligent Fault Diagnosis Method for Bearings with Multi-Source Data and Improved GASA.

In recent years, single-source-data-based deep learning methods have made considerable strides in the field of fault diagnosis. Nevertheless, the extraction of useful information from multi-source data remains a challenge. In this paper, we propose a novel approach called the Genetic Simulated Annealing Optimization (GASA) method with a multi-source data convolutional neural network (MSCNN) for the fault diagnosis of rolling bearing.

Effect of henagliflozin on left ventricular mass index in dialysis patients with HFpEF (HELD-HF): protocol for a multicentre, randomised, double-blind, placebo-controlled trial.

Introduction: Heart failure with preserved ejection fraction (HFpEF) is a prevalent comorbidity among patients with end-stage kidney disease. Although sodium-glucose cotransporter 2 inhibitors are validated in treating heart failure and ameliorating left ventricular hypertrophy among non-dialysis patients, the effects on dialysis patients are unknown. We previously investigated the pharmacokinetics of henagliflozin in patients undergoing haemodialysis (HD) or peritoneal dialysis (PD) and clarified its safety.

Smartwatch Measures of Outdoor Exposure and Myopia in Children.

Importance: Time spent outdoors has been proven effective in preventing myopia, but little is known about the association of outdoor exposure patterns with myopia.

Objective: To examine the association of outdoor exposure patterns with myopic shift in children.

Design, Setting, And Participants: This 1-year prospective cohort study from December 2017 to December 2018 was a secondary analysis of a cluster-randomized trial (Shanghai Time Outside to Reduce Myopia [STORM]).

IRF8 deficiency-induced myeloid-derived suppressor cell promote immune evasion in lung adenocarcinoma.

Background: Patients with lung adenocarcinoma (LUAD) have a low response rate to immune checkpoint blockade. It is highly important to explore the tumor immune escape mechanism of LUAD patients and expand the population of patients who may benefit from immunotherapy.

Methods: Based on 954 bulk RNA-seq data of LUAD patients and 15 single-cell RNA-seq data, the relationships between tumor immune dysfunction and exclusion (TIDE) scores and survival prognosis in each patient were calculated and evaluated, and the immune escape mechanism affecting the independent prognosis of LUAD patients was identified.

Californium-252 Intracavitary Radiotherapy for Primary Vaginal Carcinoma: A Retrospective Clinical Study.

Objective: To investigate the therapeutic effect of Cf-252 neutron intracavitary brachytherapy (ICBT) in the treatment of primary vaginal carcinoma of stage I-III, along with advanced complications.

Methods: Between August 2009 and August 2013, 41 patients with intact primary vaginal carcinoma based on the histological diagnosis at the Second Cancer Hospital of Heilongjiang Province (Beidahuang Group General Hospital) and the Daping Hospital of the Third Military Medical University were included in this study. Among them, 32 patients were squamous cell carcinoma, and 9 adenocarcinomas.

Development and validation of a clinical decision tool for preoperative micropapillary and solid pattern lung adenocarcinoma of CT ≤2 cm.

Background: Micropapillary (MP) and solid (S) pattern adenocarcinoma are highly malignant subtypes of lung adenocarcinoma. In today's era of increasingly conservative surgery for small lung cancer, effective preoperative identification of these subtypes is greatly important for surgical planning and the long-term survival of patients.

Methods: For this retrospective study, the presence of MP and/or S was evaluated in 2167 consecutive patients who underwent surgical resection for clinical stage IA1-2 lung adenocarcinoma.

Anyon quantum dimensions from an arbitrary ground state wave function.

Realizing topological orders and topological quantum computation is a central task of modern physics. An important but notoriously hard question in this endeavor is how to diagnose topological orders that lack conventional order parameters. A breakthrough in this problem is the discovery of topological entanglement entropy, which can be used to detect nontrivial topological order from a ground state wave function, but is far from enough for fully determining the topological order.

Phase-Pure α-Sn Quantum Material on Si Seeded by a 2 nm-Thick Ge Layer.

α-Sn, a new elemental topological quantum material, has drawn substantial attention lately. Unique transport properties and intriguing spintronics applications of α-Sn are demonstrated, resurrecting this material from its notorious "tin pest" infamy. With a diamond cubic crystal structure, group-IV α-Sn holds the potential for integrated topological quantum devices on Si.

Cotton transposon-related variome reveals roles of transposon-related variations in modern cotton cultivation.

Introduction: Transposon plays a vital role in cotton genome evolution, contributing to the expansion and divergence of genomes within the Gossypium genus. However, knowledge of transposon activity in modern cotton cultivation is limited.

Objectives: In this study, we aimed to construct transposon-related variome within Gossypium genus and reveal role of transposon-related variations during cotton cultivation.

Fingerprint Finder: Identifying Genomic Fingerprint Sites in Cotton Cohorts for Genetic Analysis and Breeding Advancement.

Genomic data in Gossypium provide numerous data resources for the cotton genomics community. However, to fill the gap between genomic analysis and breeding field work, detecting the featured genomic items of a subset cohort is essential for geneticists. We developed FPFinder v1.

Polylevodopa nanoplatform for lateral flow immunochromatography assay of SARS-CoV-2 and influenza A virus.

At the end of 2019, an unprecedented outbreak of novel coronavirus pneumonia ravaged the global landscape, inflicting profound harm upon society. Following numerous cycles of transmission, we find ourselves in an epoch where the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coexists alongside influenza viruses (Flu A). Swift and accurate diagnosis of SARS-CoV-2 and Flu A is imperative to stem the spread of these maladies and administer appropriate treatment.

Lung adenocarcinoma: selection of surgical approaches in solid adenocarcinoma from the viewpoint of clinicopathologic features and tumor microenvironmental heterogeneity.

Introduction: Solid adenocarcinoma represents a notably aggressive subtype of lung adenocarcinoma. Amidst the prevailing inclination towards conservative surgical interventions for diminutive lung cancer lesions, the critical evaluation of this subtype's malignancy and heterogeneity stands as imperative for the formulation of surgical approaches and the prognostication of long-term patient survival.

Methods: A retrospective dataset, encompassing 2406 instances of non-solid adenocarcinoma (comprising lepidic, acinar, and papillary adenocarcinoma) and 326 instances of solid adenocarcinoma, was analyzed to ascertain the risk factors concomitant with diverse histological variants of lung adenocarcinoma.