The transition between the inflammatory phase and the proliferative phase is critical for wound healing. However, the development of proper switchers that can regulate this transition is facing great challenges. Macrophages play versatile roles in all wound healing phases because they can readily switch from pro-inflammatory M1 phenotypes to anti-inflammatory M2 phenotypes in response to different microenvironment stimuli.
View Article and Find Full Text PDFTo develop a 9-dye fluorescent autosomal and Y chromosome STR multiplex amplification system and verify its performance. Using the 9-dye fluorescent labeling technology, construct a multiplex amplification system that uses the autosomal and Y chromosome core and preferred loci recommended by GB/T 41009-2021 national standard as candidate loci, then evaluate its accuracy, sensitivity, species specificity, and other system performance index. A 9-dye fluorescent multiplex amplification system containing 70 loci, including Amel, D5S818, D21S11, D7S820, CS1FPO, D2S1338, D19S433, D8S1132, D2S441, VWA, D8S1179, D16S539, D10S1435, PentaD, D3S3045, TPOX, TH01, D22S1045, D18S51, FGA, D19S253, D10S1248, D6S477, D6S1043, D13S317, D12S391, D15S659, PentaE, D1S1656, D3S1358, DYS460, DYS389I, DYS390, DYS533, DYS392, DYS518, DYS557, DYS570, DYS458, DYS437, DYS385, GATA-H4, DYS576, DYS643, DYS508, DYS627, DYS456, DYS391, DYF404S1, DYS438, DYS448, DYF387S1, DYS596, DYS549, DYS399S1, DYS393, DYS635, DYS439, DYS19, DYS444, DYS449, DYS481, DYS527a/b, and DYS447 was successfully constructed.
View Article and Find Full Text PDFPurpose: Research on the Minimum Clinically Important Difference (MCID) of the Brief Pain Inventory (BPI) following Total Knee Arthroplasty (TKA) is limited. This study addresses this gap by determining the MCID of the BPI for patients undergoing primary TKA.
Patients And Methods: This study was designed to quantitatively determine the MCID of the BPI for patients undergoing primary TKA.
J Prev Alzheimers Dis
February 2025
Objective: Due to the recognition for the importance of early intervention in Alzheimer's disease (AD), it is important to focus on prevention and treatment strategies for mild cognitive impairment (MCI). This study aimed to establish a risk prediction model for AD among MCI patients to provide clinical guidance for primary medical institutions.
Methods: Data from MCI subjects were obtained from the NACC.
Background: Patients with knee osteoarthritis (KOA) often experience persistent pain and functional impairment after total knee arthroplasty (TKA), which presents challenges for pain management. Accurate preoperative assessment of pain characteristics is crucial for tailoring individualized treatment plans. The PainDETECT Questionnaire has been widely used to identify neuropathic components in chronic pain and has been validated for its reliability and validity across various cultural contexts.
View Article and Find Full Text PDFIschemia-reperfusion injury is a common pathophysiological mechanism in retinal degeneration. PANoptosis is a newly defined integral form of regulated cell death that combines the key features of pyroptosis, apoptosis, and necroptosis. Oligomerization of mitochondrial voltage-dependent anion channel 1 is an important pathological event in regulating cell death in retinal ischemia-reperfusion injury.
View Article and Find Full Text PDFDopamine (DA) is an important catecholamine neurotransmitter and its abnormal concentration is closely related to diseases such as hypertension, Parkinson's disease and schizophrenia. Due to the advantages of high sensitivity and fast response for electrochemiluminescence (ECL), developing ECL sensors for detecting DA was very critical in clinical diagnosis. ECL resonance energy transfer (ECL-RET) was an effective signaling mechanism.
View Article and Find Full Text PDFBackground: Adverse effects during chemotherapy severely impact the daily diet of breast cancer (BC) patients. Engaging in dietary self-management is crucial for healthy lifestyle and recovery. This study aims to create the Dietary Self-management Behavior Questionnaire (DSMBQ) and preliminarily validate its reliability, validity, and discriminative ability for BC patients undergoing chemotherapy.
View Article and Find Full Text PDFBackground: Chronic NK-cell lymphoproliferative disease (CLPD-NK) is a very rare lymphoproliferative disorder in which patients often have an elevated lymphocyte population without clinical symptoms.
Methods: In this particular case, a middle-aged woman presented with a consistent elevation in her lymphocyte proportion over a span of four consecutive years during physical examinations, without manifesting any other notable clinical symptoms. The underlying cause of this phenomenon was ultimately identified through a comprehensive evaluation that encompassed peripheral blood cell morphology analysis, lymphocyte subset profiling, and peripheral blood immunophenotyping.
The preparation of environmentally friendly and efficient waterborne polyurethane sizing agents for carbon fiber (CF) is difficult, especially to avoid the use of isocyanates. Herein, ellagic acid and CO were used to prepare a five-membered cyclic carbonate compound (EARBO). The polymerization between EARBO and diamines enabled the preparation of highly efficient and green aqueous non-isocyanate polyurethane (WNIPU) sizing agents.
View Article and Find Full Text PDFAscorbic acid plays an important role in the synthesis and metabolism of the human body. However, it cannot be synthesized by the human body and needs to be supplemented from exogenous food intake. Ascorbic acid is easily degraded during storage and heating, often causing its content in food to change.
View Article and Find Full Text PDFObjective: Epilepsy is one of the most prevalent brain diseases. Approximately one third of patients consistently experience drug-resistant epilepsy (DRE), a condition where seizures persist despite the use of antiseizure medications. Exploration of new therapies for DRE is urgently needed.
View Article and Find Full Text PDFCadmium (Cd) is a toxic heavy metal widespread in rice paddies and threatens food safety and human health. Foliar exposure represents a cost-effective, simple, and time-independent approach to enhance rice resistance and minimize Cd accumulation. Herein, foliar spraying of carbon dots (CDs) was found to significantly reduce Cd accumulation in rice roots and shoots by 31.
View Article and Find Full Text PDFThe self-assembly material N,N-bis-(3-dimethyl aminopropyl)-3,4,9,10-perylene tetracarboxylic acid diimide (PDI) is reported to show electrochemical (EC)/electrochemiluminescence (ECL) property for designing new dual-mode dopamine (DA) sensors. KSO significantly improved the EC reduction current at -0.346 V and ECL intensity at -0.
View Article and Find Full Text PDFObjective: Our study focused on the effects and molecular mechanisms of kaempferol, a major active component of Eucommia ulmoides Oliver (EUO), on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).
Methods: Target molecules for EUO, osteoarthritis, and osteogenic differentiation were identified through network pharmacology analysis. BMSCs were isolated and treated with various concentrations of kaempferol.
MicroRNAs (miRNAs) are closely associated with cancer and have been considered cancer biomarkers. Herein, we propose an electrochemiluminescence (ECL) biosensor for detecting miRNA-21 based on target-induced catalytic hairpin self-assembly (CHA) and CuO-mediated azide-alkyne cycloaddition. Two hairpin DNAs were employed: one was immobilized on magnetic beads (HP2) and another was labeled with CuO (HP1-CuO).
View Article and Find Full Text PDFObjective: To explore the feeding practices and feeding environment of Chinese families with 6-10-month-old infants.
Design: One day of caregiver-recorded feeding occasions.
Setting: Homes in Shaanxi, China.
BMC Sports Sci Med Rehabil
September 2024
Background: Limited research has investigated the association between training load and performance of basketball players during games. Little is known about how different indicators of player performance are affected by internal and external loads. The purpose of this study was to determine whether external and internal loads influence basketball players' performance during games.
View Article and Find Full Text PDFBACKGROUNDFrailty significantly affects morbidity and mortality rates in the older population (age >65 years). Age-related degenerative diseases are influenced by the intestinal microbiota. However, limited research exists on alterations in the intestinal microbiota in frail older individuals, and the effectiveness of prebiotic intervention for treating frailty remains uncertain.
View Article and Find Full Text PDFRationale And Objectives: To explore the feasibility and predictive utility for neurological outcomes of brain computed tomography perfusion (CTP) for surgically treated acute type A aortic dissection patients with severe common carotid artery stenosis.
Materials And Methods: Consecutive acute type A aortic dissection patients with severe common carotid artery stenosis undergoing preoperative brain computed tomography perfusion and surgery at our center were examined in retrospect. Brain perfusion was assessed using parameters including cerebral blood flow, cerebral blood volume, mean transmit time, time to maximum, penumbra volume and infarct core volume.