Mimicking Bidirectional Inhibitory Synapse Using a Porous-Confined Ionic Memristor with Electrolyte/Tris(4-aminophenyl)amine Neurotransmitter.

Ionic memristors can emulate brain-like functions of biological synapses for neuromorphic technologies. Apart from the widely studied excitatory-excitatory and excitatory-inhibitory synapses, reports on memristors with the inhibitory-inhibitory synaptic behaviors remain a challenge. Here, the first biaxially inhibited artificial synapse is demonstrated, consisting of a solid electrolyte and conjugated microporous polymers bilayer as neurotransmitter, with the former serving as an ion reservoir and the latter acting as a confined transport.

Neuromorphic Nanoionics for Human-Machine Interaction: From Materials to Applications.

Human-machine interaction (HMI) technology has undergone significant advancements in recent years, enabling seamless communication between humans and machines. Its expansion has extended into various emerging domains, including human healthcare, machine perception, and biointerfaces, thereby magnifying the demand for advanced intelligent technologies. Neuromorphic computing, a paradigm rooted in nanoionic devices that emulate the operations and architecture of the human brain, has emerged as a powerful tool for highly efficient information processing.

Biocontrol potential of Bacillus velezensis wr8 secondary metabolites against Penicillium sp.

The aim of this study was to isolate and identify native Bacillus from citrus fruits, with inhibition phenotypes to Penicillium sp. We investigated the antifungal effect of Bacillus velezensis wr8 on the postharvest pathogens Penicillium sp. inoculated on fruits, as well as on the growth of these fungi on Petri dishes with defined media.

Nitrogen Fertilization Modified the Responses of Seedlings to Elevated CO in Subtropical China.

There are very few studies about the effects of relatively higher CO concentration (e.g., 1000 μmol·mol) or plus N fertilization on woody plants.

Identification of New Peptide Biomarkers for Bacterial Bloodstream Infection.

Purpose: Due to a lack of effective early diagnostic measures, new diagnostic methods for bacterial bloodstream infections (BSIs) are urgently needed. A protein-peptide profiling approach can be used to identify novel diagnostic biomarkers of BSIs.

Experimental Design: In this study, MALDI-TOF MS and nano-LC/ESI-MS/MS are used to analyze serum peptides.

Infected RBC flag/parameter provided by Mindray BC-6800 haematology analyzer aid the diagnosis of malaria.

Background: The Mindray BC-6800 haematology analyzer (BC-6800) provides a dedicated flag 'Infected RBC' (InR) and the number of InR (InR#)/the permillage of InR (InR‰) in routine blood testing as a screening tool for malaria in endemic areas. This study sought to evaluate the effectiveness of the BC-6800 flag parameter for aiding the diagnosis of malaria.

Methods: A total of 181 samples were tested using the Mindray BC-6800 haematology analyzer, including 117 malaria-infected samples collected from Yunnan, China, and 64 samples from healthy controls.

Comparing PyroMark Q24 Pyrosequencing and MALDI-TOF MS for Identification of CYP2D6*10.

Background: CYP2D6*10 is mainly responsible for the large pharmacokinetic variability of routinely administered metoprolol in middle-aged and elderly Asian patients. Utilizing an efficient method for identifying the CYP2D6*10 genotypes is clinically important for evaluating the pharmacokinetic effect of administration of metoprolol. This study attempted to evaluate the effectiveness of the two methods used to detect the rs1065852 and rs1135840 SNPs of the CYP2D6*10 gene.

Elevated O alters soil bacterial and fungal communities and the dynamics of carbon and nitrogen.

Although many studies have reported the negative effects of elevated O on plant physiological characteristics, the influence of elevated O on below-ground processes and soil microbial functioning is less studied. In this study, we examined the effects of elevated O on soil properties, soil microbial biomass, as well as microbial community composition using high-throughput sequencing. Throughout one growing season, one-year old seedlings of two important endemic trees in subtropical China: Taxus chinensis (Pilger) Rehd.

Serum peptide profiling for potential biomarkers in early diagnosis of Escherichia coli bloodstream infection.

Background: Bacterial bloodstream infection (BSI) remains an important cause of morbidity and mortality, which is a widespread and uncontrolled inflammatory response. There are some cytokines for the auxiliary diagnosis, such as procalcitonin (PCT), C reactive protein (CRP), and interleukin 6 (IL-6), which are not sufficient. This study was aimed to explore a new method of diagnosing bacterial BSI and to find some new biomarkers that could differentiate bloodstream infected patients from healthy people.

Novel urokinase-plasminogen activator inhibitor SPINK13 inhibits growth and metastasis of hepatocellular carcinoma in vivo.

Advanced hepatocellular carcinoma (HCC) is a highly aggressive malignancy that is a serious threat to the public health system of China. Urokinase-plasminogen activator (uPA) can promote the invasive growth and metastasis of HCC cells by activating matrix metalloproteinases (MMPs), leading to the breakage of the extra-cellular matrix. uPA is a promising target for advanced HCC treatment.

New design of probe and central-homo primer pairs to improve TaqMan™ PCR accuracy for HBV detection.

Quantitative PCR (qPCR) assay using TaqMan™ probe was widely used in the detection of different nucleic acids. However, this technology has several drawbacks, including false negative results caused by primer-dimer (PD) and false positive issues due to primer-probe aggregations. Here, we designed a modified TaqMan™-Molecular Beacon probe by adding an antisense base and a new type of primer pair named central-homo primer pairs bearing 5-10 bases homologous sequence on the 3' end.

Effects of elevated O on physiological and biochemical responses in three kinds of trees native to subtropical forest in China during non-growing period.

Numerous studies have documented the negative effects of ozone (O) on tree species in growing season, however, little is done in non-growing season. Three evergreen tree species, Phoebe bournei (Hemsl.) Yang (P.

How important is woody tissue photosynthesis in EuCahetus dunnii Maiden and Osmanthus fragrans (Thunb.) Lour. under O stress?

Numerous studies have demonstrated the negative effects of elevated O on leaf photosynthesis. Within trees, a portion of respired CO is assimilated by woody tissue photosynthesis, but its response to elevated O remains unclear. Saplings of two evergreen tree species, EuCahetus dunnii Maiden (E.

Rapid detection of unconjugated estriol in the serum via superparamagnetic lateral flow immunochromatographic assay.

Unconjugated estriol (uE) is one of the main naturally occurring estrogens that plays an important role in growth and development of the fetus. Usually, the level of uE is very low in men and non-pregnant women, but in pregnant women, the level of estriol has been found to be quite high. Therefore, the combination of uE, AFP, and hCG is now widely used for Down Syndrome screening as a triple marker.

Mechanism of aquaporin 4 (AQP 4) up-regulation in rat cerebral edema under hypobaric hypoxia and the preventative effect of puerarin.

Aim: We aim to investigate the mechanism of aquaporin 4 (AQP 4) up-regulation during high-altitude cerebral edema (HACE) in rats under hypobaric hypoxia and preventative effect of puerarin.

Methods: Rats were exposed to a hypobaric chamber with or without the preventative treatment of puerarin or dexamethasone. Morriz water maze was used to evaluate the spatial memory injury.

Physiological and biochemical responses of Machilus ichangensis Rehd. et Wils and Taxus chinensis (Pilger) Rehd. to elevated O in subtropical China.

Considerable researches have documented the negative effects of ozone on woody species in North America and Europe; however, little is known about how woody tree species respond to elevated O in subtropical China, and most of the previous studies were conducted using pot experiment. In the present study, Machilus ichangensis Rehd. et Wils (M.

Global topics and novel approaches in the study of air pollution, climate change and forest ecosystems.

Research directions from the 27th conference for Specialists in Air Pollution and Climate Change Effects on Forest Ecosystems (2015) reflect knowledge advancements about (i) Mechanistic bases of tree responses to multiple climate and pollution stressors, in particular the interaction of ozone (O3) with nitrogen (N) deposition and drought; (ii) Linking genetic control with physiological whole-tree activity; (iii) Epigenetic responses to climate change and air pollution; (iv) Embedding individual tree performance into the multi-factorial stand-level interaction network; (v) Interactions of biogenic and anthropogenic volatile compounds (molecular, functional and ecological bases); (vi) Estimating the potential for carbon/pollution mitigation and cost effectiveness of urban and peri-urban forests; (vii) Selection of trees adapted to the urban environment; (viii) Trophic, competitive and host/parasite relationships under changing pollution and climate; (ix) Atmosphere-biosphere-pedosphere interactions as affected by anthropospheric changes; (x) Statistical analyses for epidemiological investigations; (xi) Use of monitoring for the validation of models; (xii) Holistic view for linking the climate, carbon, N and O3 modelling; (xiii) Inclusion of multiple environmental stresses (biotic and abiotic) in critical load determinations; (xiv) Ecological impacts of N deposition in the under-investigated areas; (xv) Empirical models for mechanistic effects at the local scale; (xvi) Broad-scale N and sulphur deposition input and their effects on forest ecosystem services; (xvii) Measurements of dry deposition of N; (xviii) Assessment of evapotranspiration; (xix) Remote sensing assessment of hydrological parameters; and (xx) Forest management for maximizing water provision and overall forest ecosystem services. Ground-level O3 is still the phytotoxic air pollutant of major concern to forest health. Specific issues about O3 are: (xxi) Developing dose-response relationships and stomatal O3 flux parameterizations for risk assessment, especially, in under-investigated regions; (xxii) Defining biologically based O3 standards for protection thresholds and critical levels; (xxiii) Use of free-air exposure facilities; (xxiv) Assessing O3 impacts on forest ecosystem services.

Structure and function of rhizosphere and non-rhizosphere soil microbial community respond differently to elevated ozone in field-planted wheat.

To assess the responses of the soil microbial community to chronic ozone (O3), wheat seedlings (Triticum aestivum Linn.) were planted in the field and exposed to elevated O3 (eO3) concentration. Three treatments were employed: (1) Control treatment (CK), AOT40=0; (2) O3-1, AOT40=1.

Lethal infection by a novel reassortant H5N1 avian influenza A virus in a zoo-housed tiger.

In early 2013, a Bengal tiger (Panthera tigris) in a zoo died of respiratory distress. All specimens from the tiger were positive for HPAI H5N1, which were detected by real-time PCR, including nose swab, throat swab, tracheal swab, heart, liver, spleen, lung, kidney, aquae pericardii and cerebrospinal fluid. One stain of virus, A/Tiger/JS/1/2013, was isolated from the lung sample.

[Development and characterization of monoclonal Antibody against M-like protein of Streptococcus equi subsp. zooepidemicus from pig].

Streptococcus equi subsp. zooepidemicus belongs to lancefield group C streptococcus, which can cause disease both in animals and humans. It has been associated with a wide variety of serious infections, including meningitis, pneumonia, septic arthritis and mastitis.