Recent Advances and Challenges of Electrocatalytic N Reduction to Ammonia.

Global ammonia production reached 175 million metric tons in 2016, 90% of which is produced from high purity N and H gases at high temperatures and pressures via the Haber-Bosch process. Reliance on natural gas for H production results in large energy consumption and CO emissions. Concerns of human-induced climate change are spurring an international scientific effort to explore new approaches to ammonia production and reduce its carbon footprint.

Raising the Bar On-Bead: Efficient On-Resin Synthesis of α-Conotoxin LvIA.

α4/7-Conotoxin LvIA is an isoform-selective inhibitor of the α3β2 nicotinic acetylcholine receptor. An efficient strategy for the synthesis of this toxin is critical to advancing its utility as a probe for receptor function and as a potential pharmaceutical lead target. On-resin methods for peptide synthesis offer potential synthetic advantages; however, strategies for on-resin formation of multiple disulfides have historically been low-yielding.