Publications by authors named "Shane P Bross"
Neurooncol Pract
June 2021
Article Synopsis
- Immuno-oncotherapy (IO) has improved systemic cancer treatment outcomes but is associated with neurological complications, particularly from immune checkpoint inhibitors (ICIs).
- Common complications include autoimmune inflammatory responses affecting multiple organs, with neuroradiologic changes often misinterpreted as cancer progression.
- This review presents a case series highlighting neurological side effects linked to ICI therapy, emphasizing that accurate identification of these side effects can enhance patient care and treatment effectiveness.
Article Synopsis
- Current treatments for glioblastoma (GBM) often intervene too late, as most clinical trials focus on recurrent disease; the study proposes using a new imaging biomarker to detect progression earlier for better therapeutic opportunities.
- A review of over 600 GBM patients revealed that T2 FLAIR signal intensity (SI) changes can indicate disease progression up to 3.4 months before standard assessments, showing high sensitivity and correlating with worse patient outcomes.
- The findings suggest a need to rethink how GBM treatment response is assessed and to consider earlier intervention points in clinical trial designs to improve patient survival rates.
World Neurosurg
July 2020
Article Synopsis
- Immuno-oncotherapy (IO) is an emerging cancer treatment that shows promise but can cause autoimmune reactions, particularly in patients with brain tumors, where the immune response is often limited.
- A case study details a 70-year-old man with clear cell renal cell carcinoma who developed seizures and neurological symptoms after beginning IO treatment, which was complicated by a history of traumatic brain injury (TBI).
- The patient was diagnosed with immune-mediated encephalitis, and the study suggests that new seizures in patients on IO could indicate encephalitis, especially in those with prior TBI, raising concerns about misinterpreting these symptoms as cancer metastasis.
