Publications by authors named "Shane L"

Cooking parameters elaborated in the U.S. Department of Agriculture's Food Safety and Inspection Service Cooking Guideline for Meat and Poultry Products (Appendix A) were evaluated for inactivation of Salmonella spp.

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Policymakers in the United States (US) recommend coronavirus disease 2019 (COVID-19) vaccination with a monovalent 2023-2024 vaccine formulation based on the Omicron XBB.1.5 variant.

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The prevalence of primary hyperparathyroidism (PHPT) is increasing as routine laboratory testing for calcium and parathyroid hormone becomes more prevalent due to heightened awareness of the disease. PHPT affects multiple organ systems including the cardiovascular system. This case report highlights a patient with first degree atrio-ventricular block pre-operatively that resolved after resection of her parathyroid adenoma.

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Article Synopsis
  • The study inoculated all-beef soppressata slices with Shiga toxin-producing E. coli and monitored pathogen levels over time.
  • Vacuum-sealed slices stored at 4 °C or 20 °C showed significant reductions in bacteria, with more pronounced decreases at 20 °C after 90 days.
  • Overall, the soppressata did not support the survival or growth of the pathogens during storage, indicating a low-risk environment for these bacteria.
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Viability of cells of Listeria monocytogenes or Salmonella spp. was quantified on slices of a German-style bologna manufactured by a local butcher to contain no added antimicrobials or to include 0.9% or 1.

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Abstract: The primary objective of this study was to monitor viability of Shiga toxin-producing Escherichia coli (STEC), Salmonella spp., and Listeria monocytogenes during preparation and storage of fuet. Regarding methodology, coarse-ground pork (ca.

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Article Synopsis
  • Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids is an inflammatory syndrome that affects multiple brain structures, presenting with various neurological symptoms like ataxia and dysarthria, which complicates diagnosis due to their episodic nature.
  • A case study of a 74-year-old man revealed that his symptoms were linked to brain lesions showing T-cell infiltration, while also having a diagnosis of primary lung cancer.
  • Treatment with high-dose glucocorticoids led to significant clinical and radiographic improvement, underscoring the importance of recognizing this syndrome despite its diagnostic challenges.*
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Objectives: Pure erythroid leukemia (PEL) is exceptionally rare in the pediatric setting. Four pediatric PEL cases with t(1;16)(p31;q24) NFIA-CBFA2T3 were reported previously. We present a case of an infant with PEL presenting with erythroblastic sarcoma and harboring a novel t(1;8)(p31.

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Abstract: A total of 482 veal cutlet, 555 ground veal, and 540 ground beef samples were purchased from retail establishments in the mid-Atlantic region of the United States over a noncontiguous 2-year period between 2014 and 2017. Samples (325 g each) were individually enriched and screened via real-time PCR for all seven regulated serogroups of Shiga toxin-producing Escherichia coli (STEC). Presumptive STEC-positive samples were subjected to serogroup-specific immunomagnetic separation and plated onto selective media.

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Abstract: The viability of Shiga toxin-producing Escherichia coli (STEC), Salmonella, and Listeria monocytogenes within plant- and beef-based burgers was monitored during storage and cooking. When inoculated (ca. 3.

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Abstract: We evaluated high pressure processing to lower levels of Shiga toxin-producing Escherichia coli (STEC) and Listeria monocytogenes inoculated into samples of plant or beef burgers. Multistrain cocktails of STEC and L. monocytogenes were separately inoculated (∼7.

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A total of 514 raw pork samples (395 ground or nonintact and 119 intact samples) were purchased at retail stores in Pennsylvania, Delaware, and New Jersey between July and December 2017. All raw pork samples were screened for serogroup O26, O45, O103, O111, O121, O145, or O157:H7 cells of Shiga toxin-producing (STEC-7) using standard microbiological and molecular methods. In short, 21 (5.

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Meat bars are dried snacks containing a mixture of meat, berries, and nuts. To explore consumer awareness of meat bars, we conducted two online, nationally representative surveys and established that 70.8% (743 of 1,050) of U.

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Cooking may reduce the potential risk of salmonellosis associated with liver pâté. A 5-log reduction was achieved when inoculated pâté was cooked to an internal temperature of ≥73.8°C.

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Article Synopsis
  • A survey of chicken livers from retail stores in Delaware, New Jersey, and Pennsylvania found that 59.4% tested positive for a specific pathogen, with New Jersey showing a significantly higher rate compared to Delaware.
  • The pathogen levels varied from 6.4 most probable number (MPN)/g to 2.4 log CFU/g, with packaged livers having higher recovery rates than those directly from processors.
  • Additionally, a small number of livers from a research farm tested positive, and cold storage for 4°C or -20°C helped reduce pathogen levels, indicating a need for better intervention measures in poultry processing to minimize contamination risk.
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Coarse ground meat was mixed with non-meat ingredients and starter culture () and then inoculated with an 8-strain cocktail of Shiga toxin-producing (ca. 7.0 log CFU/g).

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All-pork mortadella, an Italian-style deli meat, was produced by a local artisanal meat producer with or without 1.0 or 1.5% liquid buffered vinegar (LBV), 0.

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Article Synopsis
  • * While tendering can contain costs, it risks reducing market competition, potentially leading to drug shortages and alternatives that may be less effective or riskier for patients.
  • * The review aims to analyze the tendering process and its effects on drug availability, along with exploring the role of biosimilars—lower-cost alternatives to branded biologics—in mitigating health care expenses and their varying integration through tendering worldwide.
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Background: Patients with cancer have an elevated risk of venous thromboembolism. Importantly, patients with cancer, who have metastatic disease, renal insufficiency, or are receiving anticancer therapy, have an even higher risk of a recurrent event. Similarly, the risk of recurrent venous thromboembolism is higher than the risk of an initial event.

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The efficacy of an electrostatic spraying system (ESS) and/or the sprayed lethality in container (SLIC) method to deliver antimicrobial agents onto the surface of beef subprimals to reduce levels of Shiga toxin-producing Escherichia coli (STEC) was evaluated. Beef subprimals were surface inoculated (lean side; ca. 5.

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Biosimilar drugs are highly similar to an originator (reference) biologic, with no clinically meaningful differences in terms of safety or efficacy. As biosimilars offer the potential for lower acquisition costs versus the originator biologic, evaluating the economic implications of the introduction of biosimilars is of interest. Budget impact analysis (BIA) is a commonly used methodology.

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Background: International guidelines recommend extended duration secondary prophylaxis in cancer patients who develop primary venous thromboembolism (VTE). Agent selection is guided in part by one large randomized trial (i.e.

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Objective: To review the scientific and regulatory aspects of biosimilar development and practical considerations for the use of biosimilars that are relevant to pharmacists.

Data Sources: Literature searches of PubMed and congress abstracts for publications pertaining to biosimilars were conducted from January 2016 to January 2017. Individual drug company web pages and governmental, regulatory, and other agency websites were also reviewed.

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Background: Patients with cancer are at increased risk of venous thromboembolism (VTE) and the risk is further elevated after a primary VTE. To reduce the risk of recurrent events, extended prophylaxis with vitamin K antagonists (VKA) is available for use. However, in a large randomized trial (Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer [CLOT]; Lee et al), extended duration dalteparin reduced the relative risk of recurrent VTE by 52% compared to VKA (=0.

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