Publications by authors named "Shane Kammerman"
Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, and the optimal timing of vaccination relative to therapy remains unknown. Severe acute respiratory syndrome coronavirus 2 vaccines created an opportunity for new insights in vaccine timing because patients were challenged with a novel antigen across multiple phases of treatment. We studied serologic messenger RNA vaccine response in retrospective and prospective cohorts with lymphoma and chronic lymphocytic leukemia, paired with clinical and research immune parameters.
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- - The study identifies the interaction between BTLA on T cells and HVEM on regulatory T cells as a major factor limiting the effectiveness of T cell-based immunotherapies in tumors.
- - High levels of BTLA in CAR T cells are linked to poorer treatment outcomes, prompting researchers to delete BTLA to improve the T cells' tumor-fighting abilities.
- - By removing BTLA, T cells show enhanced signaling and function, suggesting that targeting the BTLA-HVEM interaction could boost the success of CAR T cell therapies.
Article Synopsis
- Multisystem Inflammatory Syndrome in Childhood (MIS-C) is a serious condition following SARS-CoV-2 infection, often requiring ICU care, but is difficult to distinguish from other fever-related illnesses, causing treatment delays.
- A study involving 104 children aimed to identify diagnostic features by analyzing breath samples and blood tests, eventually finding that certain breath compounds and specific plasma proteins were linked to MIS-C.
- The findings suggest that monitoring specific immune cell markers and plasma levels could improve diagnostic accuracy for MIS-C, potentially leading to better outcomes for affected children in emergency settings.