Publications by authors named "Shane K Mathew"
Burn injury results in hypercoagulability and an increased venous thromboembolism risk. However, the most effective chemoprophylaxis for burn-injured patients has yet to be elucidated. Therefore, this study aims to identify the safety and efficacy of a burn center's venous thromboembolism protocol modification which increased the dose of enoxaparin from 40mg daily to 40mg twice daily with peak anti-Xa level adjustments.
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- ECMO usage is increasing, but determining which patients will benefit the most is challenging, making risk stratification crucial.
- This study evaluated the impact of two biomarkers, SDC-1 and soluble thrombomodulin (sTM), on mortality rates in patients on venoarterial ECMO.
- Results showed that higher levels of sTM significantly correlate with increased mortality risk, while SDC-1 levels are marginally predictive; these findings suggest that incorporating these biomarkers could enhance existing scoring systems for better patient assessment.
Introduction: Literature examining the impact of obesity on burn injury remains mixed. Previous examination of the National Burn Repository, now the BCQP, in obesity-related burn research is limited. The aim of this work was to provide an assessment of the BCQP dataset to examine the effect of obesity on burn-related outcomes.
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- Dynamically titrated crystalloids are the primary method for treating burn shock, and this study investigates whether adding allogeneic plasma (known as plasma-inclusive resuscitation, or PIR) affects coagulation negatively.
- The study involved 35 patients treated with PIR, analyzing their blood to check for coagulopathy at multiple points during treatment, finding no significant coagulation issues or complications like transfusion reactions.
- Results indicate that PIR does not cause harmful blood clotting changes compared to baseline in burn patients, suggesting it may be safe, but further research is necessary to confirm these results and assess its effectiveness in burn resuscitation.