The Generation of an ocular anti-inflammatory biotherapeutic to enhance wound healing.

Microbes exist at and colonize mucosal surfaces striking a balance with the host immune system, so that these microbes can thrive on host tissues without causing pathology. Because of this, mucosal barrier-colonizing bacteria can be leveraged to act as long-term delivery vehicles for naturally derived therapeutics. Here, we use a mouse model of corneal wound healing to show that the eye-colonizing bacterium, Corynebacterium mastitidis (C.

The double pandemic: Examining cultural stress among Asian Americans during the COVID-19 pandemic.

Objectives: To investigate patterns of cultural stress (racial discrimination and COVID stress) and their impact on ethnic identity and civic engagement among Asian American college students.

Method: 491 undergraduate students who self-identify as Asian American (female = 63.50%; = 20.

"If the college adjusted the prices…": comparing food secure and insecure college students during the COVID-19 pandemic.

We examined how students' food insecurity related to their demographic information, academic experiences, use of food programs, and reflections on food during the COVID-19 pandemic. 246 NYC undergraduates during the first 9 months of the pandemic. Students reported on food insecurity (eg, USDA's 10-item AFSSM), household income, impact of food insecurity on academics, GPA, and use of food programs.

An intersectional examination of the impact of COVID-stress and discrimination on college students' resilience and mental health.

To investigate the impact of COVID-stress and discrimination on mental health among a group of diverse college students using an intersectional framework. One thousand six hundred seventy-one undergraduate students ( = 20.42,  = 2.

Individual Differences in Patterns of Developmental Opportunity and Constraint During COVID-19: Implications for Longitudinal Well-Being.

Individual differences in sociodemographic characteristics and trait-like perceptions of opportunities and constraints may shape responses to adversities such as the onset of the COVID-19 pandemic. However, little is known about how these factors combine to form multifaceted profiles of developmental opportunity and constraint or the implications of such profiles for longitudinal well-being following major life stressors. Using a national sample of U.

Genetic Manipulation of Corynebacterium mastitidis to Better Understand the Ocular Microbiome.

Purpose: Corynebacterium spp. are Gram-positive bacteria commonly associated with the ocular surface. Corynebacterium mastitidis was isolated from mouse eyes and was demonstrated to induce a beneficial immune response that can protect the eye from pathogenic infection.

Shared and nonshared agency for occupational goals with mothers, fathers, VIPs, and romantic partners during young adulthood.

This study applied a framework of shared and nonshared agency to investigate how social partners can help and hinder young adults' career development. We also considered the extent to which motivational control could be promoted or burdened when young people seek help and encouragement from others in their careers. Based on the importance of shared agency in life goal pursuit, it was hypothesized that shared agency (i.

Associations between subjective social status and psychological well-being among college students.

Higher subjective social status (SSS) is associated with better mental health among youth; however, few studies have examined youth's perceptions of past (childhood) or future (adulthood) SSS. Utilizing latent profile analysis, we examined unique profiles of past, present, and future SSS among 401 college students in the United States and tested associations between these profiles and psychological well-being (ie, depressive symptoms, negative affect, positive affect, and flourishing), controlling for family socioeconomic status (SES). Results revealed four profiles: (8%), (18%), (43%), and (31%).

Causal Beliefs for Socioeconomic Status Attainment Scale: Development and Validation.

That individuals attain socioeconomic status (SES) through their own effort and ability, which is a staple pillar of the meritocratic ethos and has been a popular topic of inquiry within social psychology. However, this focus on merit overshadowed other important causal factors that contribute to one's SES, such as opportunity and chance. This study presents psychometrically validated scales measuring one's causal beliefs of SES attainment for themselves (agency beliefs) and others (society beliefs).

Prosociality across adulthood: A developmental and motivational perspective.

Why do people contribute to the well-being of others? What promotes or hinders their contribution? Framed by expectancy-value theory and the motivational theory of life span development, we use data from the Midlife in the United States National longitudinal study (MIDUS I, II, and III) to examine how individuals' perceived contributions to the well-being of others develop across adulthood, in the related but distinct forms of overall prosociality (more other-focused) and generativity (more self-focused). Our findings show that prosociality and generativity display similar, yet distinct trajectories, peaking in midlife a decade apart from each other, when expectancy and value for prosocial behavior are highest. Moreover, expectancy as reflected in perceived control and control strivings, and value as indicated by agreeableness, predict individuals' prosociality and generativity.

Friends, family, and romantic partners: Three critical relationships in older women's lives.

How are different social relationships jointly and uniquely associated with older women's health and well-being, and what is the directionality of these associations? We address these questions using longitudinal data from the Midlife in the United States study. We find that relationship quality with romantic partners, family, and friends is positively linked with better health and well-being concurrently and longitudinally. Cross-lagged analyses indicate that romantic relationships are more predictive of than predicted by health and well-being, family relationships are more predicted by than predictive of health and well-being, and friendships are both predicted by and predictive of health and well-being.

Risk of cognitive declines with retirement: Who declines and why?

Retiring is associated with increased risk of cognitive decline (e.g., Bonsang, Adam, & Perelman, 2012; Wickrama, O'Neal, Kwag, & Lee, 2013).

Electrochemical Strategy for Eradicating Fluconazole-Tolerant Using Implantable Titanium.

A persistent problem in modern health care derives from the overwhelming presence of antibiotic-resistant microbes on biomaterials, more specifically, fungal growth on metal-based implants. This study seeks to investigate the antifungal properties of low-level electrochemical treatments delivered using titanium electrodes against . We show that can be readily controlled with electrical currents/potentials, reducing the number of viable planktonic cells by 99.

Cortical layer-specific critical dynamics triggering perception.

Perceptual experiences may arise from neuronal activity patterns in mammalian neocortex. We probed mouse neocortex during visual discrimination using a red-shifted channelrhodopsin (ChRmine, discovered through structure-guided genome mining) alongside multiplexed multiphoton-holography (MultiSLM), achieving control of individually specified neurons spanning large cortical volumes with millisecond precision. Stimulating a critical number of stimulus-orientation-selective neurons drove widespread recruitment of functionally related neurons, a process enhanced by (but not requiring) orientation-discrimination task learning.

Engagement with six major life domains during the transition to retirement: Stability and change for better or worse.

Active engagement with multiple life domains (cross-domain engagement) is associated with adaptation throughout the adult life span. However, less is known about the role of cross-domain engagement during significant life course transitions that can challenge motivational resources, such as the shift to retirement. Based on the motivational theory of life span development (Heckhausen, Wrosch, & Schulz, 2010, 2019), the present study used 9-year data from the national Midlife in the United States Study (MIDUS; = 1,301, age = 57, = 6.

Blood meal-induced inhibition of vector-borne disease by transgenic microbiota.

Vector-borne diseases are a substantial portion of the global disease burden; one of the deadliest of these is malaria. Vector control strategies have been hindered by mosquito and pathogen resistances, and population alteration approaches using transgenic mosquitos still have many hurdles to overcome before they can be implemented in the field. Here we report a paratransgenic control strategy in which the microbiota of Anopheles stephensi was engineered to produce an antiplasmodial effector causing the mosquito to become refractory to Plasmodium berghei.

Youth's Causal Beliefs About Success: Socioeconomic Differences and Prediction of Early Career Development.

Youth's career attainment is associated with socioeconomic background, but may also be related to their beliefs about causes of success. Relationships between 17-year-olds' socioeconomic status (SES) and causal beliefs about success, and whether these beliefs predict career attainment after completing a vocational or university degree were examined using data from the German Socio-Economic Panel Study (n = 997, 48.5% female).

It's only a dream if you wake up: Young adults' achievement expectations, opportunities, and meritocratic beliefs.

The present paper examines university graduates' beliefs about how meritocratic socioeconomic status (SES) attainment in U.S. society is for themselves (merit agency beliefs) and for most other people (merit societal beliefs), and how these distinct beliefs are differentially associated with labour market experiences and achievement-goal attitudes and expectations in the aftermath of the Great Recession.

High-school predictors of university achievement: Youths' self-reported relationships with parents, beliefs about success, and university aspirations.

Associations between youths' reported relationships with their parents, beliefs about how success is attained, educational aspirations, and university completion were examined. Data come from the German Socioeconomic Panel. At age 17, youth (n = 3284) reported on their relationships with their parents, beliefs about success, and educational aspirations.

Optimized Engagement Across Life Domains in Adult Development: Balancing Diversity and Interdomain Consequences.

Adaptive lifespan development involves individuals' simultaneous coordination of motivational engagement across multiple domains of life. The present study tests this proposition using data from the Midlife in the United States National Longitudinal Study of Health and Well-Being (MIDUS I and II). Results from multilevel model analyses indicate that participants' engagement with, perceived control over, and reported quality in the domains of work, health, and family relationships follow general trajectories across adulthood that reflect age-graded and socially structured opportunities.

Evaluation of immediate and 12-week effects of a smartphone sun-safety mobile application: a randomized clinical trial.

Importance: Mobile applications on smartphones can communicate a large amount of personalized, real-time health information, including advice on skin cancer prevention, but their effectiveness may be affected by whether recipients can be convinced to use them.

Objective: To evaluate a smartphone mobile application (Solar Cell) delivering real-time advice about sun protection for a second time in a randomized clinical trial.

Design, Setting, And Participants: A previous trial conducted in 2012 used a randomized pretest-posttest design.

Smartphone mobile application delivering personalized, real-time sun protection advice: a randomized clinical trial.

Importance: Mobile smartphones are rapidly emerging as an effective means of communicating with many Americans. Using mobile applications (apps), they can access remote databases, track time and location, and integrate user input to provide tailored health information.

Objective: A smartphone mobile app providing personalized, real-time sun protection advice was evaluated in a randomized clinical trial.

Developing the eCPP: adapting an evidence-based parent training program for digital delivery in primary care settings.

Background: Developing innovative delivery methods is needed to overcome time and logistic barriers to in-person participation in evidence-based parent training (PT) programs.

Purpose: The purpose of this paper is to (a) describe the systematic process for adapting an evidence-based group PT program (the Chicago Parent Program) to a tablet-based delivery format, (b) present the adapted program, and (c) discuss opportunities and challenges of adapting evidence-based programs for alternative delivery methods.

Methods: To ensure consistency with the original program and relevance to the intended program recipients, three groups-parents (n = 10), CPP developers (n = 3), and digital delivery experts- were engaged throughout the systematic steps of the delivery adaptation of the Chicago Parent Program (eCPP).

Lifestyle factors in hypertension drug research: systematic analysis of articles in a leading cochrane report.

Established standards for first-line hypertension management include lifestyle modification and behavior change. The degree to which and how lifestyle modification is systematically integrated into studies of first-line drug management for hypertension is of methodological and clinical relevance. This study systematically reviewed the methodology of articles from a recent Cochrane review that had been designed to inform first-line medical treatment of hypertension and was representative of high quality established clinical trials in the field.