Publications by authors named "Shanaz Sikder"
Background: African Americans (AAs) are at a higher risk for developing type 2 diabetes compared with non-Hispanic whites (NHWs). The causal role of β-cell glucose sensitivity (β-GS) and insulin clearance in hyperinsulinemia in AA adults is unclear.
Objective: Using a cross-sectional study design, we compared β-cell function and insulin clearance in nondiabetic AAs (n = 36) and NHWs (n = 47) after a mixed meal test (MMT).
Context And Objective: Leptin treatment has dramatic clinical effects on glucose and lipid metabolism in leptin-deficient patients with lipodystrophy. Further elucidation of metabolic effects of exogenous leptin therapy will shed light on understanding leptin physiology in humans. Our objective was to utilize metabolomic profiling to examine the changes associated with administration of short-term metreleptin therapy in patients with lipodystrophy.
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- The study investigates the effects of 26 weeks of growth hormone (GH) administration on insulin sensitivity and glucose effectiveness in healthy older adults.
- Researchers conducted a randomized, double-blind, placebo-controlled trial, comparing measures of insulin sensitivity and glucose effectiveness before and after the treatment.
- Results showed that GH administration increased liver insulin resistance but did not affect muscle insulin sensitivity or glucose effectiveness compared to the placebo group.