VEGF-specific siRNAs modified with 2'-deoxy effectively suppress VEGF expression and inhibit growth of nasopharyngeal carcinoma xenograft in a mouse model.

Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEGF not only plays important roles in tumor angiogenesis, but also provides a target for tumor treatment with small interfering RNA (siRNA) that targets VEGF; however, it is unclear whether a quite high up-regulation of VEGF will affect the efficiency of RNA interference strategies targeting VEGF. A high level expression of VEGF was found in CNE cells from a nasopharyngeal carcinoma cell line.

[Expressions of P16 and nm23-H1 in nasopharyngeal cacinoma and their clinical significance].

Objective: To examine the expressions of P16 and nm23-H(1) protein in nasopharyngeal carcinoma (NPC) and explore their association with clinicopathology and the level of argyrophilic protein of the nucleolar organizer regions (AgNORs) of peripheral blood T lymphocyte (T-AgNORs) before radiotherapy.

Methods: SP immunohistochemistry was used to detect P16 and nm23-H(1) expressions in 65 cases of NPC, and the level of T-AgNORs was measured before radiotherapy.

Results: The positivity rate of P16 and nm23-H(1) protein in NPC was 24.