Publications by authors named "Shan-Yan Hong"
Article Synopsis
- - The study developed a human immune system (HIS) mouse model to better understand human materno-fetal immunity, which is crucial for clearing pathogens while tolerating the fetus.
- - Human immunity shows a tolerant state mid-gestation (E14.5) but becomes inflammatory by late gestation (E19), with macrophages and Treg cells playing critical roles in this immune transition.
- - This HIS mouse model can enhance our knowledge of human materno-fetal immunity and could aid in drug discovery for reproductive disorders.
Background: SARS-CoV-2 infection in pregnant women during the third trimester resulted in overall adverse pregnancy outcomes compared to non-infected controls and a unique humoral and cellular response at delivery. In this study we aimed to assess the impact of SARS-CoV-2 infection on maternal/neonatal peripartum outcomes andimmunological profiles.
Method: In this study, we recruited 304 SARS-CoV-2 infected pregnant women and 910 SARS-CoV-2 non-infected pregnant women who were admitted for delivery.
[Effects of butylphthalide on microglia activation in frontal lobe of rats after chronic sleep deprivation].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
March 2020
To evaluate the effects of butylphthalide on microglia activation and inflammatory factors in frontal lobe of rats after chronic sleep deprivation. Rats were divided into four groups(＝8): control group, platform group, chronic sleep deprivation group and butylphthalide intervention group. Chronic sleep deprivation was performed in rats of chronic sleep deprivation group and butylphthalide intervention group for 18 h per day using the multiple platforms method, and sleep deprivation lasted for 28 days.
View Article and Find Full Text PDF[The effects of prenatal radiation of mobile phones on white matter in cerebellum of rat offspring].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
January 2020
Objective: To evaluate the effects of prenatal radiation of 850～1 900 MHz mobile phone on white matter in cerebellum of adult rat offspring.
Methods: Pregnant rats were randomly divided into short term maternal radiation group, long term maternal radiation group and control group. Rats in short term and long term maternal radiation group were exposed to 6 h/d and 24 h/d mobile phone radiation during 1-17 days of pregnancy, respectively.
[Pro-apoptotic effects of curcumin associated with CIK cells against ovarian carcinoma cells].
Zhonghua Yi Xue Za Zhi
January 2013
Objective: To observe the pro-apoptotic effects of Curcumin associated with CIK cells against SKOV3 cells of ovarian carcinoma and discusses the possible molecular mechanisms.
Methods: CIK cells were induced from umbilicus cord blood. The apoptotic morphology of SKOV3 cells was observed under electron microscope after treated with Cur, CIK cells and Cur associated with CIK cells.