Publications by authors named "Shan-Xia Gao"
Article Synopsis
- The study aimed to examine how the PD-1/PD-L1 signaling pathway affects regulatory T cells (Tregs) in ovarian cancer.
- Immunohistochemistry showed that higher levels of PD-1, PD-L1, and FOXP3+ Tregs were associated with more aggressive tumors and poor patient outcomes.
- In vitro and in vivo experiments revealed that blocking PD-L1 reduced cancer cell activity and Treg differentiation, leading to decreased tumor growth and Treg recruitment in the tumor microenvironment.
The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway.
Braz J Med Biol Res
October 2019
The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients with uterine septum who had normal endometrium verified with an uteroscope. In addition, 50 rats were randomly assigned into Control, Sham, Model, NC-siRNA, and KDR-siRNA groups.
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