Publications by authors named "Shan-Shan Qian"
Background: Hemoporfin-mediated photodynamic therapy (PDT) is an effective treatment for port-wine stains (PWS), and pain is the main adverse effect of this therapy. General anesthesia is commonly used for pain management during PDT, but the effect of general anesthetics on the subsequent treatment efficacy of PDT in PWS has not been reported.
Objectives: To assess the use of general anesthesia combined with PDT compared with PDT alone in 207 PWS patients, and to provide further safety and efficacy data on this combined therapy.
Whole-Genome Sequencing Identified and Mutations in Port-Wine Stains.
Front Med (Lausanne)
July 2022
Article Synopsis
- Port-wine stains (PWSs) are congenital disorders linked to various genetic mutations affecting blood vessel development, but the specific mutations remain largely unclear.
- Researchers utilized whole-genome sequencing (WGS) on DNA from four patients to identify genetic variations, uncovering a known GNAQ mutation in one and six novel mutations across three genes in the others.
- Additionally, two of the newly identified mutations showed frequencies of 60% and 40% in tests on five other sporadic PWS patients, emphasizing the genetic diversity in PWS and paving the way for potential clinical applications.
[Improved weighted cross-correlation coefficient with a new kernel and its application in predicting T cell epitopes].
Nan Fang Yi Ke Da Xue Xue Bao
October 2010
We designed a weighted cross-correlation coefficient considering the "anchor" of the T cell epitopes, and used an evolutionary algorithm to search for an optimal weight vector. A SVM model with this new peptide similarity kernel was evaluated on a T-cell data set. The results demonstrated a good performance of this method.
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