Publications by authors named "Shan-Ru Feng"
Imbalanced Sirtuin 1 (SIRT1) levels may lead to liver diseases through abnormal regulation of autophagy, but the roles of SIRT1-regulated autophagy in hepatocellular carcinoma are still controversial. In this study, we found that SIRT1 mRNA and protein levels were upregulated in hepatocellular carcinoma, and high SIRT1 expression hinted an advanced stage and a poor prognosis. The differentially expressed proteins were significantly elevated in autophagy, cellular response to stress, and immune signaling pathways.
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- The tumor microenvironment is complex and includes tumor-associated macrophages (TAMs), which can be influenced by tumor cells to create an environment that supports tumor growth.
- This study found that liver cancer (HCC) cells cause macrophages to change into a M2-like phenotype, which is associated with promoting cancer, and that this change is linked to the role of autophagy in macrophage behavior.
- Inhibiting autophagy in macrophages leads to M2 polarization through a specific mechanism involving the NF-κB pathway, highlighting a potential target for cancer treatment by disrupting this polarization process.
Article Synopsis
- The study investigates the role of autophagy in macrophages within the tumor microenvironment of hepatocellular carcinoma (HCC), finding reduced autophagy linked to worse patient outcomes and increased metastasis.
- Researchers identified that HCC triggers decreased autophagy in macrophages by activating mTOR, which in turn promotes cancer progression through mechanisms involving the NLRP3 inflammasome and IL-1β release.
- Targeting the signaling pathways related to IL-1β showed potential as a therapeutic strategy, indicating that disrupting the feedback loop between autophagy inhibition and macrophage recruitment could help treat HCC more effectively.