Publications by authors named "Shan-Jun Tan"
Background: It has been reported that lipid-rich enteral nutrition (EN) could ameliorate inflammation in various diseases. In this study, we investigated whether lipid-rich EN could control intestinal inflammation, improve intestinal motility and mucosal barrier injury after intestinal ischemia/reperfusion (I/R) injury.
Methods: Male adult rats received saline, conventional EN, or lipid-rich EN via gavage before and after intestinal I/R injury.
Article Synopsis
- A study evaluated the effectiveness of the transversus abdominis plane (TAP) block in reducing pain and opiate use in hernia surgeries, since it's known to help with abdominal surgeries.
- The analysis included 8 randomized clinical trials with 791 patients, showing that those who received the TAP block used significantly less morphine and reported lower pain scores at 24 hours post-surgery.
- Additionally, patients with TAP block experienced less postoperative nausea and vomiting, along with fewer general complications compared to those without the block.
Article Synopsis
- In open abdominal surgeries, prolonged exposure to peritoneal air can harm the intestinal mucosal barrier, leading to complications, while high-fat enteral nutrition may help mitigate this damage.
- A study on male rats compared the effects of saline, low-fat nutrition, and high-fat nutrition before and after air exposure, measuring changes in mucosal barrier integrity and oxidative stress.
- Results showed that high-fat enteral nutrition improved intestinal barrier function and reduced oxidative stress, effectively minimizing damage compared to low-fat nutrition.
Article Synopsis
- Peritoneal air exposure during abdominal surgery can lead to inflammation and delayed recovery of bowel function, prompting the study of high-fat enteral nutrition as a potential remedy.
- The study involved male rats given different nutritional formulas before and after peritoneal air exposure, measuring their intestinal motility and inflammation levels.
- Results indicated that while both low-fat and high-fat nutrition helped improve motility and reduce inflammation, high-fat enteral nutrition was particularly effective in reversing the adverse effects caused by peritoneal air exposure.
Article Synopsis
- Sympathetic hyperactivity is linked to acute traumatic coagulopathy (ATC), and β-blockers like propranolol may help mitigate its effects on inflammation and coagulation disorders.* -
- In a study with male Sprague-Dawley rats, propranolol improved heart rate variability and reduced pro-inflammatory cytokines and markers of endothelial damage compared to the control group.* -
- Despite the beneficial effects on inflammation and endothelial health, propranolol did not significantly change overall mortality rates in the rats with ATC, indicating the need for further research on its mechanisms.*
Aim: To investigate the effects of terminal ileostomy on bacterial translocation (BT) and systemic inflammation after intestinal ischemia/reperfusion (I/R) injury in rats.
Methods: Thirty-two rats were assigned to either the sham-operated group, I/R group, I/R + resection and anastomosis group, or the I/R + ileostomy group. The superior mesenteric artery was occluded for 60 min.
Article Synopsis
- Acute traumatic coagulopathy (ATC) leads to changes in the autonomic nervous system, causing disruptions in sympathetic and parasympathetic balance, which can result in dysfunction.
- In a study involving male Sprague-Dawley rats, sympathetic nerve damage (sympathectomy) was performed to observe its effects on inflammation and coagulation after trauma and bleeding.
- Results showed that sympathectomy improved heart rate variability and reduced inflammatory markers, suggesting that targeting autonomic dysfunction could have protective benefits in ATC.
Background/aims: To assess the efficacy and safety of fast track (FT) programmes in laparoscopic colorectal surgery by comparing FT programmes with traditional care in randomized controlled trials (RCTs).
Methodology: RCTs comparing the effects of FT programmes and traditional care in the same context of laparoscopic colorectal surgery were found on PubMed, EMBASE and Cochrane Library. Primary hospital stay, overall hospital stay, readmission rate, morbidity and mortality were assessed.
Background: Postoperative fatigue syndrome (POFS) is a common clinical complication followed by almost every major abdominal surgery. Ginsenoside Rb1 (GRb1), a principle ginsenoside in ginseng, could exert a potent anti-fatigue effect on POFS. However, the mechanism is still unknown.
View Article and Find Full Text PDFBackground/aims: In critically ill patients, gastrointestinal function plays an important role in multiple organ dysfunction syndrome. Patients suffering from acute lower gastrointestinal dysfunction need to be performed a temporary fecal diversion after the failure of conservative treatment. This study aims to determine which type of fecal diversion is associated with better clinical outcomes in critically ill patients.
View Article and Find Full Text PDF[Systemic review of the safety and efficacy of fast-track surgery combined with laparoscopy in radical gastrectomy for gastric cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
October 2013
Objective: To conduct a systemic review of the safety and efficacy of fast-track surgery combined with laparoscopy in radical gastrectomy for gastric cancer.
Methods: The databases, including CNKI, Wangfang, VIP, PubMed, EMBASE and Cochrane Library, were searched to collect randomized controlled trials(RCTs) or clinical controlled trials(CCTs) on the comparison of fast-track surgery combined with laparoscopy versus fast-track surgery or laparoscopy separately used in radical gastrectomy for gastric cancer between January 1994 and December 2012. After data were extracted, meta-analysis was conducted by using RevMan 5.
[Effects of ginsenoside Rb1 on the oxidative stress in the skeletal muscles of rats with postoperative fatigue syndrome].
Zhongguo Zhong Xi Yi Jie He Za Zhi
November 2012
Objective: To observe the effects of ginsenoside Rb1 (GRb1) on the oxidative stress in the skeletal muscles of rats with postoperative fatigue syndrome (POFS) and to study its anti-fatigue mechanisms.
Methods: The POFS model was established using resection of 70% of mid-small intestine. Ninety-six Sprague-Dawley (SD) rats were screened using grasping test.
[Association of the changes of central serotonin and peripheral blood free amino acids with postoperative fatigue after abdominal surgery].
Zhonghua Wei Chang Wai Ke Za Zhi
December 2011
Objective: To explore the mechanism of postoperative fatigue syndrome(POFS) by detecting the change of central monoamine neurotransmitters in a rat model after major abdominal surgery.
Method: Eighty-four rats were randomly divided into fatigue assessment groups (including model group and sham group) and experimental groups (including postoperative day 1, 3, 5, 7, and 14 recovery groups and the corresponding control groups). Postoperative fatigue was evaluated after surgery.
Objective: Postoperative fatigue syndrome (POFS) is a general and main complication after surgery. However, there is no stable and standardized animal model for POFS. The aim of the present study was to establish a rodent model of POFS by small intestinal resection, with POFS evaluated by acknowledged physical and behavioral methods.
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