Selective ovary resistance to insulin signaling in women with polycystic ovary syndrome.

Objective: Insulin resistance is a common feature of both polycystic ovary syndrome (PCOS) and non-insulin-dependent diabetes mellitus (NIDDM); however, the persistent reproductive disturbances appear to be limited to the former, suggesting that insulin resistance in the ovary itself may confer this susceptibility.

Design: Prospective study.

Setting: University-affiliated department.