CPA4 overexpression correlates with poor prognosis and tumor progression in endometrial cancer.

Background: The rise in endometrial cancer rates globally calls for advanced diagnostic methods and new biomarkers. CPA4, known for its role in cancer development, has not yet been studied in relation to endometrial cancer, making it a promising research avenue.

Methods: We analyzed CPA4's mRNA expression using data from TCGA and GEO databases and validated these findings with 116 clinical samples through immunohistochemical analysis.

Internet-Based Cognitive Behavioral Therapy for Preventing Postpartum Depressive Symptoms Among Pregnant Individuals With Depression: Multicenter Randomized Controlled Trial in China.

Background: Women are particularly vulnerable to depression during pregnancy, which is one of the strongest risk factors for developing postpartum depression (PPD). Addressing antenatal depressive symptoms in these women is crucial for preventing PPD. However, little is known about the effectiveness of internet-based cognitive behavioral therapy (ICBT) in preventing PPD in this high-risk group.

Effect of metal ions on chlorobenzene degradation by sp. in a co-contamination system.

Co-contamination of heavy metals and chlorobenzenes (CBs) presents a significant environmental challenge, yet the impact of metal ions on CB biodegradation remains unclear. This study investigates the effects of Cd²⁺, Hg²⁺, Zn²⁺, and Fe³⁺ on the CB degradation ability of strain TF-2. The results indicate that metal ions inhibit CB biodegradation, with the most pronounced inhibitory effects observed at concentrations of 10.

Association between platelet/high-density lipoprotein cholesterol ratio and blood eosinophil counts in American adults with asthma: a population-based study.

Objective: This study aims to evaluate the relationship between the platelet-to-high-density lipoprotein cholesterol ratio (PHR) and blood eosinophil counts (BEOC) in asthmatic patients, using data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018.

Methods: This research explored the link between PHR and BEOC among adults with asthma, drawing on data from a representative U.S.

Development and validation of a deep learning-enhanced prediction model for the likelihood of pulmonary embolism.

Background: Pulmonary embolism (PE) is a common and potentially fatal condition. Timely and accurate risk assessment in patients with acute deep vein thrombosis (DVT) is crucial. This study aims to develop a deep learning-based, precise, and efficient PE risk prediction model (PE-Mind) to overcome the limitations of current clinical tools and provide a more targeted risk evaluation solution.

Controlled release of MIF siRNA and GDNF protein from a photocurable scaffold efficiently repairs spinal cord injury.

Compared with traditional treatment strategies, siRNA-based gene therapy combines with protein therapy to offer a new strategy for spinal cord injury (SCI). The siRNA and protein therapy are limited by the large and deep lesion site and local co-delivery vectors. However, the photocurable scaffold has the properties of injectable, flexible, and biodegradable, which provide a potential formulation for siRNA and protein combined therapy.

Concurrent presentation of proliferative glomerulonephritis with monoclonal immunoglobulin deposits and light chain proximal tubulopathy: a case report and review of the literature.

The simultaneous occurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) and light chain proximal tubulopathy (LCPT) presents a unique diagnostic and therapeutic challenge. PGNMID is characterized by monoclonal immunoglobulin deposition in glomeruli, leading to proliferative glomerular pathology, while LCPT involves monoclonal light chain deposition in proximal tubular cells, causing tubulointerstitial damage. Both conditions are classified under monoclonal gammopathy of renal significance (MGRS), but their coexistence in a single patient is exceedingly rare.

The RNA-Binding Protein IGF2BP1 Marks Germ Cells but Is Dispensable for Mouse Fertility.

Insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) is a key reader of N6-methyladenosine modifications that regulate target mRNA stability in eukaryotic cells; however, its role in germ cells has never been explored. Here, we analyzed the spatiotemporal expression of IGF2BP1 and revealed that it was present not only in oocytes of the mouse ovary but also in ZBTB16-positive undifferentiated spermatogonia in the mouse testis. Coimmunoprecipitation and fluorescence staining revealed that IGF2BP1 interacted with TRIM71, a regulator of spermatogonia differentiation, but that its expression was unaffected in the testes of Trim71 knockout mice.

A predictive model to assess the risk of developing hyperlipidemia in patients with type 2 diabetes.

Background: Type 2 diabetes (T2D) is increasingly recognized as a significant global health challenge, with a rising prevalence of hyperlipidemia among diabetic patients. Effectively predicting and reducing the risk of hyperlipidemia in T2D patients to mitigate their cardiovascular risk remains an urgent issue.

Objectives: The research sought to determine early clinical indicators that could predict the onset of hyperlipidemia in patients with T2D and to establish a predictive model that integrates clinical and laboratory indicators.

Insights into the Activation Mechanism of HCA1, HCA2, and HCA3.

Hydroxy-carboxylic acid receptors HCA1, HCA2, and HCA3 can be activated by important intermediates of energy metabolism. Despite the research focusing on HCA2, its clinical application has been limited by adverse effects. Therefore, the role of HCA1 as a promising target for the treatment of lipolysis warrants further exploration.

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and serum thyroid function measures: Recent Findings from NHANES 2007-2012 and Mendelian randomization.

Objective: There is limited epidemiological data regarding the association of blood lipids with thyroid hormones. Thus, the present article aims to explore whether there is an association between non-high-density to high-density lipoprotein cholesterol ratio (NHHR) and thyroid hormones.

Methods: We analyzed samples from 3,881 adults aged 20 years and above who took part in the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2012.

Inflammatory Bowel Disease and Dementia: Evidence Triangulation from a Meta-Analysis of Observational Studies and Mendelian Randomization Study.

Objective: Observational studies have found associations between inflammatory bowel disease (IBD) and the risk of dementia, including Alzheimer's dementia (AD) and vascular dementia (VD); however, these findings are inconsistent. It remains unclear whether these associations are causal.

Methods: We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia.

Engineering water-lean solvation structure to modulate interfacial chemistry for high-performance aqueous zinc-ion battery.

The stability and reversibility of aqueous zinc-ion batteries (AZIBs) are greatly restricted by the water-induced side reactions. Herein, N-methyl-d-glucamine (MGA) is devoted to modulating the interfacial microenvironment of the Zn anode to improve its stability. Thanks to the polyhydroxy and a methylamino structure, MGA molecules can effectively substitute three water molecules that originally coordinated with the Zn ions by strengthened ion-dipole interaction, thus forming a water-lean primary solvation sheath of Zn ions.

Broad-Scale Meta-Analysis of Drivers Mediating Adverse Impacts of Flow Regulation on Riparian Vegetation.

Over two-thirds of global rivers are subjected to flow regulation. Although it is widely recognized that flow regulation can adversely affect riparian vegetation-a critical component of river ecosystems-the specific roles of various drivers remain poorly understood. To address this gap, we conducted a broad-scale meta-analysis, aiming to elucidate how different factors mediate the adverse impacts of flow regulation on riparian vegetation.

Predicting Axillary Lymph Node Metastasis in Young Onset Breast Cancer: A Clinical-Radiomics Nomogram Based on DCE-MRI.

Background: Young onset breast cancer, diagnosed in women under 50, is known for its aggressive nature and challenging prognosis. Precisely forecasting axillary lymph node metastasis (ALNM) is essential for customizing treatment plans and enhancing patient results.

Objective: This research sought to create and verify a clinical-radiomics nomogram that combines radiomic features from Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) with standard clinical predictors to improve the accuracy of predicting ALNM in young breast cancer patients.

A recurrent variant c.5126C>T in a Han-Chinese family with tuberous sclerosis complex.

Objective: To identify the disease-causing variant in a family with tuberous sclerosis complex (TSC).

Methods: This study including a Han-Chinese pedigree recruited from the Third Xiangya Hospital, Central South University, Changsha, Hunan, China was conducted between February, 2019 and January, 2023. Detailed clinical examinations were performed on the proband and other family members of a Han-Chinese family with TSC.

Multicentre, multitime, multidimension, prospective follow-up cohort study on patients during the first wave of COVID-19 in China: a study protocol.

Introduction: During the first wave of the COVID-19 outbreak in China, the surge of COVID-19 cases was rapid and drastic. Emerging evidence suggests that beyond the acute phase, patients with COVID-19 may experience a wide range of postacute or long COVID sequelae. However, the mechanism and burden of COVID-19, especially long COVID, have not yet been comprehensively clarified.

Differentiation of early-stage endometrial carcinoma from benign endometrial lesions: a comparative study of six diffusion models.

Background: Accurate differentiation between benign and malignant endometrial lesions holds substantial clinical importance. This study aimed to evaluate the efficacy of various diffusion models in the preoperative diagnosis of early-stage endometrial carcinoma (EC).

Methods: A total of 72 consecutive patients with benign or malignant endometrial lesions from the First People's Hospital of Yunnan Province were prospectively enrolled between April 2021 and July 2023.

CENP-E haploinsufficiency causes chromosome misalignment and spindle assembly checkpoint activation in the spermatogonia.

Background: The establishment of kinetochore-microtubule attachment is essential for error-free chromosome alignment and segregation during cell division. Defects in chromosome alignment result in chromosome instability, birth defects, and infertility. Kinesin-7 CENP-E mediates kinetochore-microtubule capture, chromosome alignment, and spindle assembly checkpoint in somatic cells, however, mechanisms of CENP-E in germ cells remain poorly understood.

Enhanced Eicosapentaenoic Acid Production via Synthetic Biological Strategy in .

The rational dietary ratio of docosahexaenoic acid (DHA) to eicosapentaenoic acid (EPA) can exert neurotrophic and cardiotrophic effects on the human body. The marine microalga produces EPA yet no DHA, and thus, it is considered an ideal EPA-only model to pursue a rational DHA/EPA ratio. In this study, synthetic biological strategy was applied to improve EPA production in .

In Situ and In Vivo Evaluation of Multiplex Protein-Specific Glycosylation of Tumors with a Dual-SERS Encoding Strategy.

A dual-SERS encoding strategy was designed for in situ and in vivo evaluation of multiplex protein-specific glycosylation of tumors. The dual-SERS encoding strategy consisted of two pairs of dual gold nanoprobes with different diameters of 10 and 30 nm, which were encoded with four different and distinguishable Raman signal molecules. The 10 and 30 nm gold nanoprobes (Au10 and Au30 probes, respectively) were further modified with lectins and aptamers to recognize the target glycans and proteins, respectively.

Association between sleep and gallstone disease in United States adults: A cross-sectional study.

Background: Both gallstone disease and sleep disorders are important public health problems. Few studies to date have investigated the associations between sleep and gallstone disease in humans. This study aimed to assess whether sleep factors (sleep time, sleep amounts, trouble sleeping) were associated with gallstone disease in the United States adults.