Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response.

Purpose: Glymphatic function has not been explored in patients with focal cortical dysplasia (FCD)-related epilepsy. This study aimed to investigate the glymphatic system's involvement in these patients and to evaluate its correlation with response patterns to different antiseizure medications (ASMs) using diffusion tensor imaging along the perivascular space (DTI-ALPS).

Methods: Fifty-two patients with FCD-related epilepsy (10 with drug-responsive epilepsy and 42 with drug-resistant epilepsy) and 24 healthy controls (HC) were included.

Two-dimensional identification of lower limb gait features based on the variational modal decomposition of sEMG signal and convolutional neural network.

Background: Gait feature recognition is crucial to improve the efficiency and coordination of exoskeleton assistance. The recognition methods based on surface electromyographic (sEMG) signals are popular. However, the recognition accuracy of these methods is poor due to ignoring the correlation of the time series of sEMG signals.

Deciphering network dysregulations and temporo-spatial dynamics in disorders of consciousness: insights from minimum spanning tree analysis.

Objectives: The neural mechanism associated with impaired consciousness is not fully clear. We aim to explore the association between static and dynamic minimum spanning tree (MST) characteristics and neural mechanism underlying impaired consciousness.

Methods: MSTs were constructed based on full-length functional magnetic resonance imaging (fMRI) signals and fMRI signal segments within each time window.

Dynamic ultrasound-based modeling predictive of response to neoadjuvant chemotherapy in patients with early breast cancer.

Early prediction of patient responses to neoadjuvant chemotherapy (NACT) is essential for the precision treatment of early breast cancer (EBC). Therefore, this study aims to noninvasively and early predict pathological complete response (pCR). We used dynamic ultrasound (US) imaging changes acquired during NACT, along with clinicopathological features, to create a nomogram and construct a machine learning model.

Race and gender biases in assessing pain intensity and medication needs among Chinese observers.

Introduction: Pain-related decision-making can be influenced by the caregiver and sufferer's demographic factors, such as race and gender, which are commonly considered individually. However, such factors may influence pain assessment interdependently based on caregivers' stereotypical beliefs.

Objectives: This study investigated how sufferers' race and gender affect Chinese observers' evaluations of pain intensity and medication needs and the associations with the observers' race and gender-related stereotypical beliefs.

All-in-one microfluidic immunosensing device for rapid and end-to-end determination of salivary biomarkers of cardiovascular diseases.

Routine screening for cardiovascular diseases (CVDs) through point-of-care assays for at-home or community-based testing of salivary biomarkers can significantly improve patient outcomes. However, its translatability has been hindered by a dearth of biosensing devices that streamline assay procedures for rapid biomarker quantitation. To address this challenge through end-to-end engineering, we developed an in-house, all-in-one microfluidic immunosensing device that integrates on-chip vibration-enhanced incubation, magnetic-assisted separation using immune magnetic bead probes, and colorimetric readout via absorbance measurements.

Feasibility and preliminary efficacy of a systematic transaction model-guided dyadic coping nursing intervention for patients with breast cancer and their spousal caregivers: A pilot study.

Objective: This study aimed to assess the feasibility, acceptability, and preliminary efficacy of a Systematic Transaction Model (STM)-guided dyadic coping nursing intervention for patients with breast cancer and their spouses.

Methods: A single-arm, pre-test/post-test pilot study was conducted at a tertiary hospital in Wuxi, China, recruiting 28 breast cancer patient-caregiver pairs. Each dyad participated in six hybrid intervention sessions.

N-glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer.

Liver metastasis is the primary factor contributing to unfavorable prognosis in colorectal cancer (CRC). Although N-glycosylation is implicated in metastasis, there is a notable paucity of comprehensive studies addressing the N-glycosylation proteomics associated with liver metastasis in CRC. In this study, N-glycosylated proteins and N-glycosylation sites of differential expression between primary lesions and paired liver metastatic lesions are identified.

Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study.

Background: Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and causes vision impairment and blindness. The presence of major risk factors for DR, such as high levels of HbA1c, does not predict all DR pathogenesis in the clinic, which suggests that uncovering the underlying mechanisms and identifying novel markers are needed. Previous evidence has shown that the serum metabolic signature of DR is unique and detectable compared with that of diabetes mellitus (DM).

Antioxidant Behavior of Carbon/Carbon Composites with Hot Dip Plating and Electroplating for Single-Crystal Furnaces.

In the Czochralski single-crystal silicon manufacturing industry, single-crystal furnaces often experience corrosion from silicon vapor, which reduces their operational lifespan. However, the preparation of metal coatings on the surface of C/C composites is challenging due to their low coefficient of thermal expansion and the intricate structure of carbon fibers. To address this issue and achieve high-quality alloy coatings, Ni-Al and Ni-Al/Si composite coatings are successfully prepared on the surface of C/C composites through a combination of electroplating and hot-dip plating, and their oxidation behavior at elevated temperatures is thoroughly investigated.

Influence of Relative Humidity on the Mechanical Properties of Palm Leaf Manuscripts: Short-Term Effects and Long-Term Aging.

Palm leaf manuscripts are a valuable part of world cultural heritage. Studying the mechanical properties of palm leaf manuscripts and their changes due to environmental influences is of great significance for understanding the material characteristics, aging mechanisms, and preventive conservation of these manuscripts. This study used dynamic vapor sorption (DVS) and a thermomechanical analyzer (TMA) to investigate the changes to the mechanical properties of palm leaf manuscripts in response to different relative humidity conditions and different time periods.

Neuroticism and cerebral small vessel disease: A genetic correlation and Mendelian randomization analysis.

Objectives: The association of neuroticism and cerebral small vessel disease (CSVD) development remains unclear. In this study, we used Mendelian randomization (MR) to explore the potential role of neuroticism in CSVD development.

Methods: We collected data on ischemic stroke (IS); small vessel stroke (SVS); three neuroimaging markers altered in CSVD, including white matter hyperintensity (WMH), fractional anisotropy (FA), and mean diffusivity (MD); and three neuroticism clusters, including depressed affect, worry, sensitivity to environmental stress and adversity (SESA), from large-scale genome-wide association studies (GWAS).

Global research hotspots and trends in anti-inflammatory studies in dry eye: a bibliometric analysis (2004-2024).

Background: Inflammation plays a crucial role in the pathophysiology of dry eye (DE). This study aims to provide a comprehensive overview of the current status, hotspots and trends in DE anti-inflammatory research through bibliometric analysis.

Method: All publications were searched using the Web of Science Core Collection (WoSCC) database from 2004 to 2024.

Worm-like Micelle Formation of Sugar-Based Nonionic Surfactant with Multibranched Methyl Chains.

The aggregation properties of sugar-based surfactants with methyl groups at multiple positions on the linear alkyl chain are an understudied topic. Therefore, in this study, we performed a structural analysis of aggregates formed by two types of sugar-based nonionic surfactants with multibranched methyl chains, 3,7,11-trimethyldodecyl maltoside (CMal), as well as with a linear chain, dodecyl--d-maltoside (CMal), in aqueous solutions using rheological and small-angle X-ray scattering techniques. CMal showed an excellent performance in lowering surface tension (28.

Retinal Neurovascular Impairment in Full-Course Diabetic Retinopathy: The Guangdong Diabetic Retinopathy Multiple-Omics Study.

Purpose: The purpose of this study was to explore the succession of the central and peripheral neurovascular and microstructural impairments in patients with full-course diabetic retinopathy (DR), consisting of preclinical DR, nonproliferative DR (NPDR), and proliferative DR (PDR).

Methods: Our analysis included 81 participants (including 23 healthy controls, 23 with preclinical DR [diabetes without retinopathy], 13 with NPDR, and 22 with PDR) from the Guangdong Diabetic Retinopathy Multiple Omics Study. Retinal structure and function were evaluated and quantified using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA), electroretinography (ERG), and adaptive optics scanning laser ophthalmoscopy (AOSLO).

Symptom clusters and network analysis in patients with gynecologic cancer undergoing chemotherapy: A cross-sectional study.

Objective: This study aimed to explore the complex relationships among symptoms and symptom clusters in patients with gynecologic cancer receiving chemotherapy using symptom network analysis, and to identify core symptoms and core symptom clusters.

Methods: A cross-sectional study was conducted at the Affiliated Hospital of Jiangnan University from December 2023 to June 2024, including 221 patients with gynecologic tumors. Participants completed demographic and clinical information questionnaires and the Chinese version of the MD Anderson Symptom Inventory (MDASI-C).

A Supramolecular Approach to Engineering Living Cells with Enzymes for Adaptive and Recyclable Cascade Synthesis.

Biocatalytic transformation in nature is inherently dynamic, spontaneous, and adaptive, enabling complex chemical synthesis and metabolism. These processes often involve supramolecular recognition among cells, enzymes, and biomacromolecules, far surpassing the capabilities of isolated cells and enzymes used in industrial synthesis. Inspired by nature, here we design a supramolecular approach to equip living cells with these capacities, enabling recyclable, efficient cascade reactions.

Graphene Oxide Functionalized GelMA Platform Loaded With BFP-1 for Osteogenic Differentiation of BMSCs.

Spinal fusion is the ultimate choice for most patients with severe disc degeneration, and bone tissue engineering offers novel strategies to improve intervertebral bone growth and fusion. In this study, we utilized graphene oxide (GO) and methacrylated gelatin (GelMA) to prepare GelMA/GO composite hydrogel scaffolds with different GO concentrations. By characterizing the various properties of the scaffolds, it was learned that the composite scaffold containing 1.

Unlocking the full potential of memory T cells in adoptive T cell therapy for hematologic malignancies.

In recent years, immune cell therapy, particularly adoptive cell therapy (ACT), has shown superior therapeutic effects on hematologic malignancies. However, a challenge lies in ensuring that genetically engineered specific T cells maintain lasting anti-tumor effects within the host. The enduring success of ACT therapy hinges on the persistence of memory T (T) cells, a diverse cell subset crucial for tumor immune response and immune memory upkeep.

Evaluating the influence of alternating flooding and drainage on antimony speciation and translocation in a soil-rice system.

The quantitative evaluation of antimony (Sb) accumulation in rice has garnered significant attention due to the potential risks to human health. A pot experiment was conducted to investigate the essential nodes of Sb transfer in soil-rice system. Seven step extract results showed that during the flooding period, organic matter releasing was the primary factor contributing 14.

Effects of Perillaldehyde and Polyamines on Defense Mechanisms of Sweet Potatoes against .

Sweet potato () serves as a significant food and economic crop worldwide. However, its production and safety are jeopardized by black rot, a disease caused by . Although polyamines (PAs) are common biological growth factors, their function in the storage of fruits and vegetables remains poorly understood.

Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.

Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer because of the difficulty in diagnosis and its resistance to chemotherapy. Focal adhesion kinase (FAK) is found overexpressed in PDAC, and targeting FAK has been proved to impede the progress of PDAC. However, most of FAK inhibitors were reported to bind with FAK in a DFG-in conformation, leading to a limited anti-tumor effect in clinical studies.