Histone acetylation alteration by KAT6A inhibitor WM-1119 suppresses IgE-mediated mast cell activation and allergic inflammation via reduction in AP-1 signaling.

Activation of immunoglobulin E (IgE)-associated mast cells (MCs) triggers the onset of pro-inflammatory signals associated with type I allergic diseases. Although histone acetylation changes have been associated with inflammatory diseases, the impact of lysine-acetyltransferase (KAT) inhibitors on IgE-mediated MCs function is unclear. Potential anti-allergic effects of the KAT6A inhibitor WM-1119 on IgE-mediated MCs activation and allergic inflammation were examined in this study.

Deciphering the Significance of Platelet-Derived Chloride Ion Channel Gene (BEST3) Through Platelet-Related Subtypes Mining for Non-Small Cell Lung Cancer.

This study investigates platelet-related subtypes in non-small cell lung cancer (NSCLC) and seeks to identify genes associated with prognosis, focusing on the clinical significance of the chloride ion channel gene BEST3. We utilised sequencing and clinical data from GEO, TCGA and the Xena platform, building a risk model based on genetic features. TCGA and GSE37745 served as training cohorts, while GSE50081, GSE13213, GSE30129 and GSE42127 were validation cohorts.

Salicylic acid cooperates with different small molecules to control biotic and abiotic stress responses.

Salicylic acid (SA) is a phytohormone that plays a critical role in plant growth, development, and response to unfavorable conditions. Over the past three decades, researches on SA have deeply elucidated the mechanism of its function in plants tolerance to infection by biotrophic and hemibiotrophic pathogens. Recent studies have found that SA also plays an important role in regulating plants response to abiotic stress.

Multi-dimensional hybrid bilinear CNN-LSTM models for epileptic seizure detection and prediction using EEG signals.

Objective: Automatic detection and prediction of epilepsy are crucial for improving patient care and quality of life. However, existing methods typically focus on single-dimensional information and often confuse the periodic and aperiodic components in electrophysiological signals.

Approach: We propose a novel deep learning framework that integrates temporal, spatial, and frequency information of EEG signals, in which periodic and aperiodic components are separated in the frequency domain.

Susceptibility of Mitophagy-Deficient Tumors to Ferroptosis Induction by Relieving the Suppression of Lipid Peroxidation.

The identification of ferroptosis-sensitive cancers is critical for the application of ferroptosis-inducing therapies in cancer therapy. Here, patient-derived organoid screening models of colorectal cancer are established to identify tumors that are sensitive to ferroptosis-inducing therapy. This study discovers that patient-derived tumors characterized by mitophagy deficiency are hypersensitive to ferroptosis-inducing therapies.

Exploring Cortical and Hippocampal Changes in Temporal Lobe Epilepsy Using Automated MRI Segmentation Techniques.

Background: To investigate the applicability of MR-based automated segmentation techniques in evaluating cortical and hippocampal changes in adults with temporal lobe epilepsy (TLE), specifically emphasizing the affected hemisphere.

Methods: A retrospective analysis involved 48 cases diagnosed with TLE based on clinical and EEG criteria. The cohort comprised 30 patients with hippocampal sclerosis (HS) and 18 with nonlesional temporal lobe epilepsy (TLE-NL) on MR.

Voluntary running exercise promotes maturation differentiation and myelination of oligodendrocytes around Aβ plaques in the medial prefrontal cortex of APP/PS1 mice.

Background: Previous studies have reported that running exercise could improves myelinization in hippocampus. However, the effects of running exercise on the differentiation and maturation of oligodendrocytes, and myelination surrounding Aβ plaques in the medial prefrontal cortex (mPFC) of the Alzheimer's disease (AD) brain have not been reported.

Methods: Forty 10-month-old male APP/PS1 AD mice were randomly divided into the AD group and the AD running (AD+RUN) group, while 20 age-matched wild-type littermate mice were included in the WT group.

METTL16 controls airway inflammations in smoking-induced COPD via regulating glutamine metabolism.

The persistent airway inflammation is the main characteristic of chronic obstructive pulmonary disease (COPD), typically caused by an indoor environment pollution cigarette smoke (CS). METTL16 is an mA methyltransferase that has been proven to be closely associated with the occurrence of various diseases. However, its exact role in smoking-induced COPD remains to be investigated.

Impact of inspiratory muscle training on aspiration symptoms in patients with dysphagia following ischemic stroke.

Objective: To investigate the impact of inspiratory muscle training on lung function and swallowing function in patients with dysphagia-induced aspiration following ischemic stroke and to evaluate the effectiveness of inspiratory muscle training on aspiration symptoms.

Methods: Fifty-eight inpatients with dysphagia-induced aspiration following ischemic stroke were selected and randomly divided into a control group (n = 29, conventional swallowing therapy) and a treatment group (n = 29, conventional swallowing therapy plus inspiratory muscle training). Both groups received conventional swallowing function training, including oral sensory training, oral motor training, airway safety protection training, and neuromuscular electrical stimulation therapy for 10-20 min per session, twice daily for 2 weeks.

sp. nov., an anamorphic yeast species isolated from plant leaves.

Two yeast strains, NYNU 224191 and NYNU 22411, were isolated from plant leaves of and sp. harvested from Qingyuan Mountain, Quanzhou City, Fujian Province, southeast China. Molecular phylogenetic analyses demonstrated that these two strains represent a novel species in the genus .

Interaction between coronaviruses and the autophagic response.

In recent years, the emergence and widespread dissemination of the coronavirus SARS-CoV-2 has posed a significant threat to global public health and social development. In order to safely and effectively prevent and control the spread of coronavirus diseases, a profound understanding of virus-host interactions is paramount. Cellular autophagy, a process that safeguards cells by maintaining cellular homeostasis under diverse stress conditions.

Leading edge biosensing applications based on AIE technology.

Luminescent materials provide a unique method for biological imaging. Luminescent probes can label molecules of interest and present luminescent signals. Bioluminescence bioimaging has shown great efficacy in environmental, live cell and animal studies.

Flow cytometry-based method to detect and separate Mycoplasma hyorhinis in cell cultures.

Mycoplasma hyorhinis is a frequently observed contaminant in cell cultures, and its detection and purification pose considerable challenges. Fragments or other cell components are similar in size to those of Mycoplasma; therefore, distinguishing them is difficult. In this study, we used Hoechst staining in combination with carboxyfluorescein succinimidyl ester (CFSE) to label Mycoplasma.

A systematic review and meta-analysis of the efficacy and safety of traditional Chinese medicine in the treatment of rhinosinusitis.

Background: Rhinosinusitis (RS), a common inflammatory disorder, adversely affects quality of life and can progress to serious complications without intervention. Conventional therapies, including antibiotics and corticosteroids, exhibit inherent limitations and risks. Traditional Chinese medicine (TCM), with its extensive historical use in RS management, remains understudied in contemporary evaluations.

Global hotspots and trends in tea anti-obesity research: a bibliometric analysis from 2004 to 2024.

Background: The prevalence of obesity and its related ailments is on the rise, posing a substantial challenge to public health. Tea, widely enjoyed for its flavors, has shown notable potential in mitigating obesity. Yet, there remains a lack of exhaustive bibliometric studies in this domain.

Strong long ties facilitate epidemic containment on mobility networks.

The analysis of connection strengths and distances in the mobility network is pivotal for delineating critical pathways, particularly in the context of epidemic propagation. Local connections that link proximate districts typically exhibit strong weights. However, ties that bridge distant regions with high levels of interaction intensity, termed strong long (SL) ties, warrant increased scrutiny due to their potential to foster satellite epidemic clusters and extend the duration of pandemics.

South China Sea records Late Miocene reorganization of western Pacific deep circulation.

Oceanic gateways play a crucial role in controlling global ocean circulation. However, gateway effects on low-latitude deep-water circulation are poorly understood. The South China Sea, located in the western Pacific, was influenced by changes in the equatorial and low-latitude gateways, which recorded significant oceanographic variations since the Oligocene.

Integrative pharmacological analysis of modified Zuojin formula: Inhibiting the HIF-1α-mediated glycolytic pathway in chronic atrophic gastritis.

Ethnopharmacological Relevance: Zuojin formula (ZJF) is a well-known herbal medicine in Pharmacopoeia of China, which is widely used for gastritis. Modified Zuojin formula (MZJF) was adapted based on traditional Chinese medicine (TCM) theories concerning gastric atrophy and dysplasia, along with extensive clinical experience, has been clinically employed to treat chronic atrophic gastritis (CAG). However, the underlying mechanisms by which MZJF intervenes in CAG remain to be fully elucidated.

Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer.

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt to their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth and contributes to treatment resistance. In primary breast cancer, metabolic shifts such as the Warburg effect and enhanced lipid synthesis are closely linked to chemotherapy failure. Similarly, metastatic lesions often display distinct metabolic profiles that not only sustain tumor growth but also confer resistance to targeted therapies and immunotherapies.