Publications by authors named "Shan Gou"
Chronic exposure to arsenic (As), a ubiquitous contaminant, poses deleterious health risks to humans, including cardiovascular disease. Recent studies have implicated ferroptosis, in which the essential micronutrient selenium (Se) plays a crucial role, in several As-induced pathological processes. However, whether Se can counteract As-induced endothelial dysfunction through ferroptosis remains unclear.
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- Impaired intestinal homeostasis is a key issue in inflammatory bowel diseases (IBD), where mannose and selenium (Se) show promise for anti-inflammatory and anti-oxidative benefits.
- A novel treatment strategy was developed using mannose-functionalized silicon nanoparticles (M-SeNPs) delivered via a colon-targeted hydrogel system, enhancing uptake by intestinal epithelial cells (IECs).
- In a mouse model of colitis, this approach reduced oxidative stress and inflammation, stabilizing IECs and providing a potential new method for treating IBD.