Publications by authors named "Shan Fa Yu"

Periodontitis is a progressive inflammatory skeletal disease characterized by periodontal tissue destruction, alveolar bone resorption, and tooth loss. Chronic inflammatory response and excessive osteoclastogenesis play essential roles in periodontitis progression. Unfortunately, the pathogenesis that contributes to periodontitis remains unclear.

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Article Synopsis
  • Noise-induced hearing loss (NIHL) is influenced by genetic and environmental factors, and this study focuses on the role of the PCDH15 gene in NIHL risk among a Chinese population.
  • Compared to individuals with the TT genotype of rs11004085, those with CT/CC genotypes showed a significantly higher risk of developing NIHL, with an odds ratio of 2.64.
  • The research also found that certain genetic variations interacted with high levels of noise exposure, increasing the risk further, particularly the TAGCC haplotype in noisy environments.
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This study proposes a new framework as job burden-capital model for comprehensive assessment on occupational stress. 1618 valid samples were recruited from electronic manufacturing service industry in Hunan province by self-rated questionnaires after written consent. Structural equation model analysis was employed to verify the model by the data collected.

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To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 diesel engine testing workers exposed to DEE and 127 non-DEE-exposed workers as study subjects. We performed lung function tests and measured cytokinesis-block micronucleus (CBMN) cytome index and levels of urinary polycyclic aromatic hydrocarbons (PAHs) metabolites. There was a significant decrease of forced expiratory volume in 1 second (FEV), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV/ FVC), maximal mid expiratory flow curve (MMF), forced expiratory flow at 50% of FVC (FEF), and forced expiratory flow at 75% of FVC (FEF) in the DEE-exposed workers than non-DEE-exposed workers (all p<0.

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Objective: In this study, we aimed at exploring the association between work-related musculoskeletal disorders (WMSDs) and work organization based on a case-control study.

Methods: A total of 1938 workers who claimed to suffer from WMSDs were selected from Beijing, Henan, Hubei, and the Guangdong province. The control group consisted of 2009 workers employed in similar industries without severe disease or musculoskeletal discomforts.

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The concentration of chromium in the blood (CrB) has been confirmed as a biomarker for occupational chromium exposure, but its biological exposure indices (BEIs) are still unclear, so we collected data from the years 2006 and 2008 (Shandong Province, China) to analyze the relationship between the concentration of chromium in the air (CrA) of the workplaces and CrB to establish a reference value of CrB for biological monitoring of occupational workers. The levels of the indicators for nasal injury, kidney (β2 microglobulin (β2-MG)), and genetic damages (8-hydroxy-deoxyguanosine (8-OHdG) and micronucleus (MN)) were measured in all subjects of the year 2011 (Henan Province, China) to verify the protective effect in this reference value of CrB. Compared with the control groups, the concentrations of CrA and CrB in chromium exposed groups were significantly higher (P < 0.

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Objective: To evaluate whether Club (Clara) cell protein (CC16) and surfactant-associated protein D (SP-D) can be used as biomarkers for lung injury caused by chromium exposure.

Methods: The concentrations of chromium in the air (CrA), chromium in the blood (CrB), lung function, CC16, SP-D, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were detected in 91 chromium-exposed workers and 38 controls.

Results: In chromium-exposed group, the levels of CrA, CrB, SP-D, TNF-α, and IL-6 were significantly higher, whereas forced expiratory volume in one second (FEV1), FEV1/FVC, maximal expiratory flow (MEF), maximum ventilation volume (MVV), CC16, and CC16/SP-D were lower.

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Objective: To investigate the co-effect of Demand-control-support (DCS) model and Effort-reward Imbalance (ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used respectively.

Methods: A total of 3 632 males and 1 706 females from 13 factories and companies in Henan province were recruited in this cross-sectional study. Perceived job stress was evaluated with the Job Content Questionnaire and Effort-Reward Imbalance Questionnaire (Chinese version).

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Objective: The health surveillance proposal for chromate exposed workers was provided and analyzed on the evidence-based study and then to be improved.

Method: Firstly, the related literatures were searched about liver damage, micronuclei, urinary chromium and hexavalent chromium exposure in Evidence Based Medicine Reviews such as Cochran library, OVID Medline, Web of knowledge in December 2011; and then, these literatures were reviewed in according to inclusion and exclusion criteria; 22 articles totally were retrieved, evaluated and classified in according to the grading standard by Oxford Centre for Evidence-based Medicine.Finally, field epidemiological investigation was further adopted to confirm the efficiency and feasibility of this proposal, combined with cost-effectiveness analysis:the ratio of total cost divided survival years was used to express the cost-effectiveness.

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Both hexavalent chromium [Cr (VI)] exposure and folate deficiency have been associated with increased cancer risks. Our previous studies have found folate deficiency in Cr (VI) exposed population. Here the relationship between some tumor markers and folate status in long-term Cr (VI) exposure was investigated carefully to show the multiple aspects of Cr (VI) carcinogenesis.

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Objective: To evaluate the chromium (Cr) levels in blood and urine among general population in China between 2009 and 2010, and thereby to analyze its prevalent features.

Methods: From year 2009 to 2010, a total of 11 983 subjects of general population aged between 6 and 60 year-old were recruited from 24 districts in 8 provinces in eastern, central and western China mainland, by cluster random sampling method. The information about their living environment and health status were collected by questionnaire, and 11 983 blood samples and 11 853 urine samples were also collected.

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Objective: To explore the risk factors of low back pain among the Chinese occupational population in several major industries.

Methods: A total of 7200 subjects (3600 cases and 3600 controls) were randomly sampled from a cross-sectional study, and they were investigated for individual and occupational factors of low back pain. The potential risk factors were first selected by using chi-square tests.

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Objective: This study aimed to investigate the epidemiological characteristics and correlated factors of daily hassles among thermal power plant workers.

Methods: A mass screening of daily hassles and correlated factors was conducted on 498 workers from a thermal power plant in Zhengzhou in July, 2008. The questionnaires included Daily Hassles Questionnaires, Work Roles Questionnaires, Job Content Questionnaires (Chinese version), Effort-Reward Imbalance (Chinese version), Work Locus of Control Scale and Type A Behavior Scale, with content covering demographic characters and occupational stress correlated factors among subjects.

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Objective: To study the biological exposure index of carbon disulfide in China.

Methods: High-performance liquid chromatography (HPLC) was used to detect the levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) in the urine of the workers after working shift end, Gas chromatography was used to detect the concentrations of the carbon disulfide in the workplace air. The relationship between the urine TTCA levels and the concentrations of the carbon disulfide was analyzed, the biological exposure index and judgement result from PC-TWA were compared.

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Objective: Establishment of determination method of 2-thiothiazolidine-4-carboxylic acid (TTCA) in urine with HPLC.

Methods: A volume of 0.5 ml hydrochloric acid (2 mol/L) and 0.

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Objective: Establishment of determination method of carbon disulfide in charcoal tube with low toxicity solvents desorption-gas chromatography.

Methods: Four types of solvent with low toxicity are applied respectively as substitution of benzene to desorb the carbon disulfide in samples of charcoal tube. The signal strength and desorption efficiency of the detector are compared by using different solvents.

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Objective: To investigate the exposure levels of carbon disulfide (CS(2)) for a chemical fiber industry.

Methods: The concentration of CS(2) was monitored in representative workshops and types of work, and the datas of that over the years were collected.

Results: The short-term exposure concentration of CS(2) about 80% of the type of work was less than or equal to 10 mg/m(3), which of more than 90% was less than or equal to 20 mg/m(3).

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Objective: To study the effects of long-term exposure to carbon disulfide (SC(2)) on cardiovascular system of workers.

Methods: The concentrations of CS(2) were detected in the representative workshops with different exposure levels. The indicators related to cardiovascular system were tested in 633 workers occupationally exposed to CS(2), which included blood pressure, electrocardiogram, blood routine (blood RT), cholesterol (TCHO), triglyceride (TG) and so on.

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Objective: To evaluate the reliability and validity of musculoskeletal questionnaire.

Methods: A self-administered modified musculoskeletal questionnaire was used to investigate 12 098 workers from eight occupations, i.e.

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Objective: To investigate the effect of combined occupational exposure of chromium and iron on erythrocyte metabolism, and the possible mechanism.

Methods: A total of 115 chromate production workers were selected in a chemical factory of Jinan as exposure group, Dec, 2008, and 60 healthy residents from a community which was far away from the factory were enrolled as control group. Environmental concentrations of chromium and iron were collected by filter membrane sampling and determined.

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Article Synopsis
  • The study aimed to investigate the impact of chronic chromate exposure on the pulmonary ventilation function of workers in a chromate manufacturing factory in Henan Province, comparing them to a control group without exposure.
  • Results from 2010 and 2011 showed significant decreases in vital lung function measurements (like FVC and FEV1) among the chromate-exposed workers compared to the control group, indicating negative effects on respiratory health.
  • Despite the observed declines, the classification of pulmonary dysfunction among both groups remained similar, primarily categorized as "limit type," suggesting that the extent of dysfunction didn't change significantly over the exposure period.
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