The effects of poly(3,4-ethylenedioxythiophene) coating on magnesium degradation and cytocompatibility with human embryonic stem cells for potential neural applications.

Magnesium (Mg) is a promising conductive metallic biomaterial due to its desirable mechanical properties for load bearing and biodegradability in human body. Controlling the rapid degradation of Mg in physiological environment continues to be the key challenge toward clinical translation. In this study, we investigated the effects of conductive poly(3,4-ethylenedioxythiophene) (PEDOT) coating on the degradation behavior of Mg substrates and their cytocompatibility.

Antimicrobial properties of biodegradable magnesium for next generation ureteral stent applications.

Bacterial infection often causes clinical complications and failure of indwelling medical devices. This is a major problem of current ureteral stents, which are used clinically to treat the blockage of ureteral canals. This study investigates the effectiveness and applicability of magnesium as a novel biodegradable ureteral stent material that has inherent antimicrobial properties.

Electrochemical deposition and evaluation of electrically conductive polymer coating on biodegradable magnesium implants for neural applications.

In an attempt to develop biodegradable, mechanically strong, biocompatible, and conductive nerve guidance conduits, pure magnesium (Mg) was used as the biodegradable substrate material to provide strength while the conductive polymer, poly(3,4-ethylenedioxythiophene) (PEDOT) was used as a conductive coating material to control Mg degradation and improve cytocompatibility of Mg substrates. This study explored a series of electrochemical deposition conditions to produce a uniform, consistent PEDOT coating on large three-dimensional Mg samples. A concentration of 1 M 3,4-ethylenedioxythiophene in ionic liquid was sufficient for coating Mg samples with a size of 5 × 5 × 0.