Corticosteroids combined with low-dose methotrexate in the treatment of pemphigus vulgaris: A retrospective cohort study.

The treatment of pemphigus vulgaris (PV) often requires long-term systemic corticosteroids. Although new biologicals like rituximab are changing the landscape, traditional immunosuppressants still prevail in many underdeveloped areas. One such medication is methotrexate (MTX), which has been widely used in autoimmune and autoinflammatory diseases, but its role in treating pemphigus remains somewhat unclear and controversial.

Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study.

Background: This study aimed to provide a comprehensive review of adverse events (AEs) associated with factor Xa (FXa) inhibitors in pediatric patients.

Methods: We searched PubMed, Embase, Cochrane Library, ClinicalTrials.gov, and the European Union Clinical Trials Register for English-language records from the establishment of the database up to October 17, 2023.

Damage growth characteristics on the exit surface of fused silica by the low-temporal coherence light irradiation.

The growth of fused silica surface damage poses a high risk in operating high-power laser devices, with complex physical mechanisms related not only to the wavelength, pulse width, fluence of incident pulse lasers, but also to initial damage size and material properties. With low-temporal coherence light (LTCL) increasingly applied in high-power laser-driven inertial confinement fusion (ICF), LTCL-induced damage growth has become a bottleneck limiting output power improvements. This paper analyzes LTCL damage growth characteristics and mechanisms on fused silica surfaces, obtaining its damage growth coefficient and threshold.

Abemaciclib increases the risk of venous thromboembolism in breast cancer: Integrate meta-analysis, pharmacovigilance database analysis, and in vitro validation.

Background: Recently, cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have emerged as a novel treatment strategy for breast cancer. However, increasing reports of CDK4/6i-associated venous thromboembolism (VTE) have garnered attention. This study assessed CDK4/6i-associated VTE in breast cancer, and examined the effect of CDK4/6i on platelet/coagulation function for the first time in vitro.

Effects of PCSK9 on thrombosis and haemostasis in a variety of metabolic states: Lipids and beyond (Review).

Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors are widely recognised as being able to induce a potent reduction in low‑density lipoprotein‑cholesterol. An increasing number of studies have suggested that PCSK9 also influences the haemostatic system by altering platelet function and the coagulation cascade. These findings have significant implications for anti‑PCSK9 therapy in patients with specific coagulation conditions, including expanded indications, dose adjustments and drug interactions.

Evaluation of clinical factors and outcome of systemic glucocorticoid therapy discontinuation in patients with pemphigus achieving complete remission.

Therapy discontinuation of systemic glucocorticoid treatment for pemphigus remains uncertain at the clinical end point of complete remission. The objective of this study was to identify the factors associated with achieving complete remission off therapy (CROT) and analyze the occurrence of relapse after therapy discontinuation. A retrospective cohort study was conducted at the Department of Dermatology of Peking University First Hospital.

Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell transplantation: PAH risk score.

Skin and soft tissue infections (SSTIs) refer to infections involving the skin, subcutaneous tissue, fascia, and muscle. In transplant populations with hematological malignancies, an immunocompromised status and the routine use of immunosuppressants increase the risk of SSTIs greatly. However, to date, the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation (HSCT) patients remain unclear.

Risk of infection in roxadustat treatment for anemia in patients with chronic kidney disease: A systematic review with meta-analysis and trial sequential analysis.

Many studies demonstrated that roxadustat (FG-4592) could increase hemoglobin (Hb) levels effectively in anemia patients with chronic kidney disease (CKD). However, its safety remains controversial. This study aims to explore the risk of infection for CKD patients treated with roxadustat, especially focused on sepsis.

A prognostic model (BATAP) with external validation for patients with transplant-associated thrombotic microangiopathy.

Transplant-associated thrombotic microangiopathy (TA-TMA) is a potentially life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Information on markers for early prognostication remains limited, and no predictive tools for TA-TMA are available. We attempted to develop and validate a prognostic model for TA-TMA.

Delayed postoperative radiotherapy increases the incidence of radiographic local tumor progression before radiotherapy and leads to poor prognosis in spinal metastases.

Background: Most previous studies focused on the minimum interval between surgery and radiotherapy in spinal metastases, leaving the maximum interval under-investigated. However, in real world, limited radiotherapist and equipment cannot meet the needs of a large patient population to obtain timely radiotherapy after the index spine surgery in developing countries. This study aimed to estimate the clinical risks of delayed radiotherapy after surgery in patients with spinal metastases in developing country.

High-power, low-coherence laser driver facility.

We report the first (to the best of our knowledge) high-power, low-coherence Nd:glass laser delivering kilojoule pulses with a coherent time of 249 fs and a bandwidth of 13 nm, achieving the 63%-efficiency second-harmonic conversion of the large-aperture low-coherence pulse and good beam smoothing effect. It provides a new type of laser driver for laser plasma interaction and high energy density physics research.

Thermochromic and Femtosecond-Laser-Induced Damage Performance of Tungsten-Doped Vanadium Dioxide Films Prepared Using an Alloy Target.

Thermochromic tungsten-doped VO₂ thin films were successfully fabricated using a W-V alloy target. X-ray diffraction analyses showed that the W-doped VO₂ film had a preferred orientation of (011), and that the doping did not degrade the film crystallinity compared with that of the pure film. X-ray photoelectron spectroscopy and energy-dispersive spectroscopy showed that the doped 0.

Ultrasonic impregnation of MnO/CeO and its application in catalytic sono-degradation of methyl orange.

MnO/CeO catalyst was prepared by ultrasonic impregnation method. The traditional and stirring impregnation methods were used as control. Results showed that ultrasonic impregnation was the best synthesis method.

Effects and mechanism of diclofenac degradation in aqueous solution by US/Zn.

A system of ultrasound radiation coupled with Zn was applied to degrade diclofenac. The effects of initial pH, dosage of Zn and ultrasound density were investigated. To further explore the mechanism of the microcosmic reaction, the fresh and used Zn powders were characterized by SEM, XRD and XPS.

Diclofenac degradation in water by FeCeO catalyzed HO: Influencing factors, mechanism and pathways.

The degradation of diclofenac in a like Fenton system, FeCeO-HO, was studied in details. The influencing factors, reaction kinetics, reaction mechanism and degradation pathways of diclofenac were investigated. The optimum conditions were at a solution pH of 5.

NiFe(CO) as a heterogeneous Fenton catalyst for removal of methyl orange.

This paper studies a heterogeneous Fenton catalyst NiFe(CO), which showed better catalytic activity than Ni(CO) and better re-usability than Fe(CO). The methyl orange removal efficiency was 98% in heterogeneous Fenton system using NiFe(CO). The prepared NiFe(CO) had a laminated shape and the size was in the range of 2-4 μm, and Ni was doped into catalyst's structure successfully.

Preparation of a magnetic N-Fe/AC catalyst for aqueous pharmaceutical treatment in heterogeneous sonication system.

High efficiency and facile separation are desirable for catalysts used in water treatment. In this study, a magnetic catalyst (nitrogen doped iron/activated carbon) was prepared and used for pharmaceutical wastewater treatment. The catalyst was characterized using BET, SEM, XRD, VSM and XPS.

Sonocatalytic degradation of diclofenac with FeCeO particles in water.

This paper studies the sonocatalytic degradation of diclofenac in water using FeCeO-catalyzed ultrasound. The effects of pre-adsorption and gas addition were investigated. Nitrogen adsorption/desorption, SEM, XRD, Raman and XPS analyses of FeCeO before and after sonication were characterized.

Degradation of aniline by heterogeneous Fenton's reaction using a Ni-Fe oxalate complex catalyst.

A Ni-Fe oxalate complex catalyst was synthesized and characterized by means of Brunauer-Emmet-Teller (BET) method, scanning electron microscope (SEM) and X-ray photo-electron spectroscopy (XPS). The catalyst showed good catalytic activity for aniline degradation by heterogeneous Fenton's reaction, in which the synergetic index was 9.3.

Rapid degradation of dyes in water by magnetic Fe(0)/Fe3O4/graphene composites.

Magnetic Fe(0)/Fe3O4/graphene has been successfully synthesized by a one-step reduction method and investigated in rapid degradation of dyes in this work. The material was characterized by N2 sorption-desorption, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating-sample magnetometer (VSM) measurements and X-ray photoelectron spectroscopy (XPS). The results indicated that Fe(0)/Fe3O4/graphene had a layered structure with Fe crystals highly dispersed in the interlayers of graphene, which could enhance the mass transfer process between Fe(0)/Fe3O4/graphene and pollutants.

Preparation of FeCeOx by ultrasonic impregnation method for heterogeneous Fenton degradation of diclofenac.

FeCeOx has been successfully synthesized by ultrasonic impregnation method and applied in diclofenac removal in heterogeneous Fenton process. The effects of ultrasonic density, impregnation time, mole ratio of Fe and Ce and calcination temperature were investigated. Nitrogen adsorption/desorption, SEM, XRD, HRTEM, Raman and XPS analyses were characterized.

MnO2/CeO2 for catalytic ultrasonic decolorization of methyl orange: Process parameters and mechanisms.

MnO2/CeO2 catalyst was prepared and characterized by means of Brunauer-Emmet-Teller (BET) method, X-ray diffraction (XRD) and scanning electron microscope (SEM). The characterization showed that MnO2/CeO2 had big specific surface area and MnO2 was dispersed homogeneously on the surface of CeO2. Excellent degradation efficiency of methyl orange was achieved by MnO2/CeO2 catalytic ultrasonic process.

Directional single-mode emission from coupled whispering gallery resonators realized by using ZnS microbelts.

Ring microcavities were formed by wrapping ZnS microbelts, which act as the waveguide and gain region of the microcavities on the surface of optical fibers. The ring microcavities with the formation of whispering gallery modes have lasing threshold lower (Q-factor higher) than that of the ZnS microbelts. The excitation of TM modes could also be suppressed by the ring geometries of ZnS microbelts.