Publications by authors named "Shamus Toomath"
Background: Ex situ machine perfusion facilitates the assessment of livers prior to transplantation. However, currently available markers of liver function poorly predict long-term graft function. Indocyanine green (ICG) is a liver-specific dye which, although common in vivo, has never been comprehensively evaluated for the assessment of graft quality during ex situ machine perfusion.
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- Current machine perfusion technology allows for the temporary preservation of livers outside the body to evaluate their viability for transplant purposes.
- The study focused on developing a long-term ex situ perfusion model that involves splitting a liver and simultaneously perfusing both halves, using a red blood cell-based solution under warm conditions.
- Results indicated promising outcomes, with median viability and survival times of 125 hours and 165 hours respectively, supported by various metrics such as lactate clearance and bile production, showcasing the potential for improved organ assessment and treatment.
Background: Normothermic machine perfusion permits the ex vivo preservation of human livers before transplantation. Long-term perfusion for days-to-weeks provides the opportunity for enhanced pretransplant assessment and potential regeneration of organs. However, this risks microbial contamination and infection of the recipient if the organ is transplanted.
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