Publications by authors named "Shams Shakil"
Article Synopsis
- A 26-year-old woman developed a petechial rash and low platelet count (thrombocytopenia) two weeks after receiving the Moderna COVID-19 vaccine, leading to her being admitted to the emergency room.
- During her hospital stay, her condition was complicated by elevated liver enzymes (transaminitis), which improved after treatment with intravenous steroids and immunoglobulin.
- Extensive tests ruled out other possible causes for her symptoms, and although there was no definitive proof, the timing of her vaccination suggested that the vaccine might have triggered her health issues.
A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels.
View Article and Find Full Text PDFHeyde syndrome is a triad of bleeding colonic angiodysplasia, aortic stenosis, and acquired coagulopathy. It is most commonly seen in the elderly between 60-80 years of age. We present a case of Heyde syndrome presenting with severe anemia secondary to bleeding angiodysplasia or arteriovenous malformations (AVM) in the lower gastrointestinal (GI) tract.
View Article and Find Full Text PDFGastric small cell carcinoma (GSCC) is a rare entity in the western hemisphere. GSCC's typically arise in the upper one-third of the stomach and have histologic features similar to those of small-cell lung carcinoma (SCLC). They have an aggressive natural history that is characterized by early and widespread metastases.
View Article and Find Full Text PDFBackground: We report a single institution's experience from a small series of patients suggesting that liver metastasis in metastatic castration-refractory prostate cancer (mCRPC) represents a relatively aggressive subtype that is refractory to hormonal manipulation treatment, including luteinizing hormone-releasing hormone agonist (LA) and abiraterone (Ab) therapy, although docetaxel is briefly effective.
Methods: Between 2007 and 2013, six patients with prostate cancer with liver metastases were analyzed. Biochemical response was defined as > 50% decrease in prostate-specific antigen (PSA) value.