Publications by authors named "Shamma Al-Muraikhy"
Unlabelled: Cell culture plays a crucial role in addressing fundamental research questions, particularly in studying insulin resistance (IR) mechanisms. Multiple models are utilized for this purpose, but their technical distinctions and relevance to conditions remain unclear. This study aims to assess the effectiveness of existing models in inducing IR and their ability to replicate IR conditions.
View Article and Find Full Text PDFThe immunomodulatory effect of physical activity can impact insulin signaling differentially in adipose tissues and skeletal muscle cells, depending on sport intensity. In this study, the effect of serum from elite athletes with varying endurance levels and playing different power sports on cytokine secretion and insulin signaling in preadipocyte and skeletal muscle cell lines was investigated. Preadipocytes (3T3-L1) and skeletal muscle cells (C2C12) were cultured in media containing pooled sera from elite athletes who play high-endurance (HE), high-power (HP), or low-endurance/low-power (LE/LP) sports for 72 h.
View Article and Find Full Text PDFImpaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin resistance. Therefore, we hypothesize that inhibition of GATA3 could promote adipogenesis, restore healthy fat distribution, and enhance insulin signaling.
View Article and Find Full Text PDF(1) Background: Young non-obese insulin-resistant (IR) individuals could be at risk of developing metabolic diseases including type 2 diabetes mellitus. The protective effect of physical activity in this apparently healthy group is expected but not well characterized. In this study, clinically relevant metabolic profiles were determined and compared among active and sedentary insulin-sensitive (IS) and IR young non-obese individuals.
View Article and Find Full Text PDFBiological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and identify the metabolic predictors of LTL in elite male soccer players.
View Article and Find Full Text PDFArticle Synopsis
- Aerobic exercise activates the complement system in the blood, but the effects of age and high-intensity training on this system, inflammation, oxidative stress, and cellular aging are not fully understood.
- A study analyzed serum samples from 79 elite athletes in both high and low/moderate endurance sports, comparing two age groups: under 30 and over 30.
- Results showed that younger high endurance athletes had significantly lower levels of certain complements (C2, C3b/iC3b, adipsin) and negative correlations with telomere length, indicating less inflammation and lower markers of cellular aging compared to their older counterparts.
Article Synopsis
- - This study examines how different sport intensities affect immune responses, cytokine levels, oxidative stress markers, and telomere length in aging elite athletes, using blood samples from 80 participants divided into three intensity groups.
- - Results show that older athletes had higher levels of TNF-α, while IL-10 and IL-6 concentrations varied by sport intensity and age group. There's also a notable correlation between cytokine levels and antioxidant activity, with telomere length positively linked to sport intensity, especially in younger athletes.
- - The conclusion indicates that high-intensity athletes experienced less aging, as evidenced by longer telomeres and higher cytokine levels, suggesting a stronger immune response compared to those in lower intensity sports,