Publications by authors named "Shamini Chandran"
An inherent genetic enzyme disorder in humans, known as glucose-6-phosphate dehydrogenase (G6PD) deficiency, arises due to specific mutations. While the prevailing approach for investigating G6PD variants involves biochemical analysis, the intricate structural details remain limited, impeding a comprehensive understanding of how different G6PD variants of varying classes impact their functionality. This study 22 examined the dynamic properties of G6PD wild types and six G6PD variants from 23 different classes using molecular dynamic simulation (MDS).
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- The study investigates the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among Thai individuals diagnosed with malaria, as well as among control subjects, to better inform malaria treatment options.
- Using phenotypic tests and high-resolution melting (HRM) analysis, researchers identified various G6PD mutations, discovering new double missense variants and assessing their biochemical impacts.
- Findings revealed a 6.13% prevalence of severe G6PD deficiency and an additional 15.20% with intermediate deficiency, with structural instability identified as a key factor affecting enzyme function linked to these mutations.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency disorder affecting over 400 million individuals worldwide. G6PD protects red blood cells (RBC) from the harmful effects of oxidative substances. There are more than 400 G6PD mutations, of which 186 variants have shown to be linked to G6PD deficiency by decreasing the activity or stability of the enzyme.
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