Loss of CASK Accelerates Heart Failure Development.

[Figure: see text].

Differential cardiac remodeling in preload versus afterload.

Background: Hemodynamic load regulates myocardial function and gene expression. We tested the hypothesis that afterload and preload, despite similar average load, result in different phenotypes.

Methods And Results: Afterload and preload were compared in mice with transverse aortic constriction (TAC) and aortocaval shunt (shunt).