Loss of CASK Accelerates Heart Failure Development.

[Figure: see text].

Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII.

Ionizing radiation (IR) is an integral part of modern multimodal anti-cancer therapies. IR involves the formation of reactive oxygen species (ROS) in targeted tissues. This is associated with subsequent cardiac dysfunction when applied during chest radiotherapy.

Differential cardiac remodeling in preload versus afterload.

Background: Hemodynamic load regulates myocardial function and gene expression. We tested the hypothesis that afterload and preload, despite similar average load, result in different phenotypes.

Methods And Results: Afterload and preload were compared in mice with transverse aortic constriction (TAC) and aortocaval shunt (shunt).