New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus KMM 4689.

Seven new deoxyisoaustamide derivatives (-) together with known compounds (-) were isolated from the coral-derived fungus KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations.

Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of and Genera.

Low molecular weight secondary metabolites of marine fungi , and sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques.

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus .

Seven known echinulin-related indolediketopiperazine alkaloids (-) were isolated from the Vietnamese sediment-derived fungus . Using chiral HPLC, the enantiomers of cryptoechinuline B () were isolated as individual compounds for the first time. (+)-Cryptoechinuline B () exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease.

Piltunines A-F from the Marine-Derived Fungus KMM 4668.

Six new carotane sesquiterpenoids piltunines A-F (-) together with known compounds (-) were isolated from the marine-derived fungus KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of - were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations.

New dihydrobenzofuranoid from the marine-derived fungus KMM 4664.

One new dihydrobenzofuran derivative (), known depsipeptide emericellamide A (), three known drimanes () and two artifact drimane derivatives (, ) were isolated from the marine-derived fungus KMM 4664. Their structures were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configuration of was determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra.

Virescenosides From the Holothurian-Associated Fungus Kmm 4401.

Ten new diterpene glycosides virescenosides Z-Z (-) together with three known analogues (-) and aglycon of virescenoside A () were isolated from the marine-derived fungus KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods.

Biologically Active Metabolites from the Marine Sediment-Derived Fungus .

Four new compounds were isolated from the Vietnamese marine sediment-derived fungus , one aspyrone-related polyketide aspilactonol G (), one meroterpenoid 12-epi-aspertetranone D (), two drimane derivatives (,), together with five known metabolites (,,,,,). The structures of compounds - were established by NMR and MS techniques. The absolute stereoconfigurations of compounds and were determined by a modified Mosher's method.

Naphto-Γ-pyrones from the marine-derived fungus .

Nine naphto-γ-pyrones rubrofusarine B (), TMC 256 A1 (), fansecinones A () and B (), aurasperones A (), B () and F (), dianhydro-aurasperone C () and asperpyrone B () were isolated from the marine-derived fungus KMM 4694. Their structures were established based on spectroscopic methods. The effect of the substances on viability and colony formation of human drug-resistant prostate cancer 22Rv1 cell was evaluated.

Citriperazines A-D produced by a marine algae-derived fungus sp. KMM 4672.

Four new diketopiperazine alkaloids, citriperazines A-D were isolated from algae-derived sp. KMM 4672. The structures of compounds were determined using spectroscopic methods.

Auroglaucin-related neuroprotective compounds from Vietnamese marine sediment-derived fungus .

Two new auroglaucin-derived compounds, niveoglaucins A () and B (), together with four known related compounds were isolated from extract of the marine sediment-derived strain of . The structures of these compounds were determined by 1D and 2D NMR spectroscopy and high resolution MS. The plausible biosynthetic pathway was proposed for new compounds and .

Asperindoles A⁻D and a -Terphenyl Derivative from the Ascidian-Derived Fungus sp. KMM 4676.

Four new indole-diterpene alkaloids asperindoles A⁻D (⁻) and the known -terphenyl derivative 3″-hydroxyterphenyllin () were isolated from the marine-derived strain of the fungus sp., associated with an unidentified colonial ascidian. The structures of ⁻ were established by 2D NMR and HRESIMS data.

Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina.

Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1-5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1-5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra.

Erylosides F, V-V, and W-W - New triterpene oligoglycosides from the Carribean sponge Erylus goffrilleri.

Seven new triterpene glycosides, erylosides F (1), V (2), V (3), V (4), W (5), W (6) and W (7), were isolated from a Carribean sponge Erylus goffrilleri collected from the Carribean Sea near the Arrecife-Seco reef (Cuba). Structures of the glycosides were determined using H and C NMR spectroscopy, including 2D NMR procedures (H-H COSY, H-С HMBC, H-С HSQC and NOESY) and HR ESI mass spectrometry. Erylosides 1 and 4 have 14-carboxy-24,25-dimethyllanost-8(9)-en-3β,25-diol as aglycone whereas glycosides 2, 3, 5, 6 and 7 are 14-carboxy-24-acetoxy-24-methyllanost-8(9)-en-3β-ol glycoconjugates.

Zosteropenillines: Polyketides from the MarineDerived Fungus Penicillium thomii.

Twelve new polyketides, zosteropenillines A-L (1-12), together with known polyketide pallidopenilline A (13), were isolated from the ethylacetate extract of the fungus Penicillium thomii associated with the seagrass Zostera marina. Their structures were established based on spectroscopic methods. The absolute configuration of zosteropenilline A (1) as 4R, 5S, 8S, 9R, 10R, and 13S was determined by a combination of the modified Mosher's method, X-ray analysis, and NOESY data.

Pallidopenillines: Polyketides from the Alga-Derived Fungus Penicillium thomii Maire KMM 4675.

Eleven new polyketides, pallidopenillines 1-11, were isolated from the alga-derived fungus Penicillium thomii. The structures of these compounds were established based on spectroscopic methods. The absolute configuration of pallidopenilline A (1) as 4R, 5S, 8S, 9R, 10R, 13R was established using a combination of the modified Mosher's method, X-ray analysis, and NOESY data.

Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672.

Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spectroscopic methods.

New 6,6-Spiroketal from the Alga-Derived Fungus Penicillium lividum.

The new 6,6-spiroketal,sargassopenilline H (1), and known peneciraistin C (2) have been isolated from an EtOAc extract of the marine-derived fungus Penicillium lividumKMM 4663. The structure of the new metabolite was determined by HR ESIMS and 1D and 2D NMR spectroscopy. Sargassopenilline H (1) in non-cytotoxic concentration inhibited colony formation of RPMI-7951 and MDA-MB-231 cell lines.

New Metabolites from a Marine Sediment-Derived Fungus, Aspergillus carneus.

A new polyketide 1 and a new decaline derivative 2 were isolated from a sediment-derived fungus Aspergillus carneus Blochwitz, together with one known bisabolane sesquiterpenoid and seven known polyketide metabolites. The structures of the isolated compounds were established by HR-MS, and 1D and 2D NMR spectroscopy. The cytotoxic and antiradical activities of the isolated compounds were evaluated.

Sargassopenillines A-G, 6,6-spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum.

Seven new 6,6-spiroketals, sargassopenillines A-G (1-7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher's method and by CD data.

Oxirapentyns A, B and E from the marine-derived strain of Isaria felina KMM 4639 as stimulators of initial stages of development of agricultural plants.

Oxirapentyn A (1), oxirapentyn B (2), and oxirapentyn E (3) were examined for their ability to stimulate growth of seedling roots of barley (Hordeum vulgare L.), buckwheat (Fagopyrum esculentum Moench), corn (Zea mays L.), soy {Glycine max (L.

Oxirapentyns F-K from the marine-sediment-derived fungus Isaria felina KMM 4639.

Six new highly oxygenated chromene derivatives, oxirapentyns F-K (2-7), one new polyketide (8), one new benzofurane (9), and two known cyclodepsipeptides, isoisariin B and isaridin E, were isolated from the lipophilic extract of the marine-derived fungus Isaria felina KMM 4639. The structures of compounds 2-9 were determined using spectroscopic methods. The relative configurations of compounds 2-7 were established through a combination of NOE data and spin coupling constants, and these results were confirmed by X-ray crystallographic analysis of 4.

Meroterpenoids from the alga-derived fungi Penicillium thomii Maire and Penicillium lividum Westling.

Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data.

New metabolites from the algal associated marine-derived fungus Aspergillus carneus.

The new oxepin-containing (1) and quinazolinone (2) alkaloids and new dihydrobenzofuran derivative (3) have been isolated from a marine strain of Aspergillus carneus KMM 4638. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR, along with Marfey's method.

Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge.

Six new triterpenoids (1-6) and the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one were isolated from a Penares sp. sponge collected from Vietnamese waters. Structures of the obtained compounds were established by extensive 1D and 2D NMR spectroscopy and mass spectrometry.