Administration and Monitoring Burden of High-Efficacy Disease-Modifying Therapies for Multiple Sclerosis: A Delphi Consensus of Clinical Experts from Saudi Arabia.

Introduction: The emergence of high-efficacy disease-modifying therapies (HE DMT) for multiple sclerosis (MS) may pose challenges to the administration and monitoring burden of the therapies. This article presents the results of the Delphi consensus method to generate insights from experts on the administration and monitoring burden of HE DMT in Saudi Arabia with a special focus on cladribine.

Methods: Between January and March 2023, a two-round modified Delphi method was used to establish consensus regarding the administration and monitoring burden of HE DMTs used for MS.

Safety and Effectiveness of Early Primary Stent Placement for Hepatic Artery Stenosis in Liver Transplant Recipients.

Purpose: To evaluate the outcomes of early primary stent placement (within 30 days of liver transplantation) for hepatic artery stenosis (HAS).

Materials And Methods: Patients who underwent liver transplantation between February 2001 and February 2024 were evaluated for HAS. Patients who underwent primary stent placement were selected and stratified based on the time from anastomosis to intervention.

Financial and digital financial literacy through social media use towards financial inclusion among batik small enterprises in Indonesia.

Batik, an Indonesian textile art form, holds immense economic and cultural importance. Small and medium enterprises (SMEs) specialising in batik play a crucial role in Indonesia's economic growth and cultural preservation, contributing significantly to the gross domestic product (GDP) and preserving the nation's heritage. Nevertheless, these enterprises face several challenges, such as slow growth and limited access to credit.

Asymptomatic Systemic Mastocytosis Uncovered During Routine Colonoscopy: A Case Report.

We report an atypical case of systemic mastocytosis in a 66-year-old asymptomatic female, diagnosed incidentally during a routine colonoscopy. This case highlights the diversity of clinical presentations and emphasizes the role of colonoscopy and the need for thorough histopathological examinations in routine endoscopic procedures with subtle abnormalities.

Dissemination, virulence characteristic, antibiotic resistance determinants of emerging linezolid and vancomycin-resistant Enterococcus spp. in fish and crustacean.

Enterococci are emerging nosocomial pathogens. Their widespread distribution causes them to be food contaminants. Furthermore, Enterococci can colonize various ecological niches and diffuse into the food chain via contaminated animals and foods because of their remarkable tolerance to unfavorable environmental circumstances.

Behaviors, hygiene habits, and sources of care among removable complete and partial dentures wearers: A multicenter cross-sectional study.

Objectives: There is a lack of data regarding the hygiene practices and sources of care among individuals in Yemen who wear removable complete and partial dentures. The purpose of this study was to explore the behaviors, hygiene habits, and sources of care information among patients who utilize complete and partial dentures in Yemen.

Materials And Methods: A descriptive cross-sectional research design was utilized, and a sample of 217 consecutive participants who wore removable complete and/or partial dentures were enlisted.

The advantages of inhalational sedation using an anesthetic-conserving device versus intravenous sedatives in an intensive care unit setting: A systematic review.

Background: Sedation is fundamental to the management of patients in the intensive care unit (ICU). Its indications in the ICU are vast, including the facilitating of mechanical ventilation, permitting invasive procedures, and managing anxiety and agitation. Inhaled sedation with halogenated agents, such as isoflurane or sevoflurane, is now feasible in ICU patients using dedicated devices/systems.

Modelling the mass adoption of mobile payment for e-hailing services using SEM-MGA.

Secured financial transactions can now be conveniently made via mobile devices for various products and services, such as e-hailing. However, limited research exists on the factors influencing the adoption of mobile payments specifically for e-hailing services, despite the growing interest in mobile payments in China. This cross-sectional study quantitatively assessed the influence of perceived usefulness, perceived ease of use, social influence, facilitating conditions, perceived security, and lifestyle compatibility on the intention to adopt and the actual adoption of mobile payment for e-hailing services.

Modeling the intention and donation of second-hand clothing in the context of an emerging economy.

The culture of fast fashion accelerates the consumption rate of individuals but at the expense of significant environmental stress. With a large amount of discarded clothing accumulating in landfills, it is crucial to encourage people to dispose of second-hand clothing (SHC) as sustainably as possible, especially in an emerging economy with large volume consumption. Through a survey of 619 respondents from China, this study explored the factors affecting people's intentions and actual donation behaviors toward SHC.

Immunohistochemical expression of CD117 in borderline, low- and high-grade ovarian surface epithelial tumours: A clinicopathological study.

Introduction: Ovarian cancer is one of leading causes of cancer related death in gynecology. CD117 is a tyrosine kinase receptor that plays an important role in regulation of apoptosis, cell proliferation and adhesion by binding to its ligand-stem cell factor. Recent studies demonstrated its aberrant overexpression in various malignancies and concluded that it may play a pivotal role in carcinogenesis.

Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells.

The development of epithelial-to-mesenchymal transition (EMT) like features is emerging as a critical factor involved in the pathogenesis of acute myeloid leukaemia (AML). However, the extracellular signals and the signalling pathways in AML that may regulate EMT remain largely unstudied. We found that the bone marrow (BM) mesenchymal/fibroblastic cell line HS5 induces an EMT-like migratory phenotype in AML cells.

Envisaging the job satisfaction and turnover intention among the young workforce: Evidence from an emerging economy.

As the economy evolves and markets change after Covid-19, demand and competition in the labor market increase in China, and employees become increasingly concerned about their career opportunities, pay, and organizational commitment. This category of factors is often considered a key predictor of turnover intentions and job satisfaction, and it is important that companies and management have a good understanding of the factors that contribute to job satisfaction and turnover intentions. The purpose of this study was to investigate the factors that influence employees' job satisfaction and turnover intention and to examine the moderating role of employees' job autonomy.

Evaluation of Saffron (Crocus Sativus L) Effects on Anxiety in Hospitalized Patients with Acute Coronary Syndrome.

Background: Anxiety is a common psychiatric condition in cardio-vascular diseases. Saffron appears to have a wide range of therapeutic effects on psychiatric conditions and cardio-vascular disorders. The aim of this study was to determine the effect of saffron on anxiety in hospitalized patients with acute coronary syndrome (ACS).

Happiness at workplace on innovative work behaviour and organisation citizenship behaviour through moderating effect of innovative behaviour.

The current study primarily aims to investigate the happiness at workplace (HAW)-innovative work behaviour (IWB) correlation through the mediating effect of organisation citizenship behaviour (OCB) and moderating effect of organisational innovative culture (OIC). Notably, 383 questionnaires were collected from lecturers employed in three local universities in Malaysia and subsequently evaluated using structural equation modelling (PLS-SEM). Based on the study outcomes, HAW positively and significantly affected employees' IWB through the mediating and moderating effects of OCB and OIC, respectively.

Awareness, practices and perceptions of community pharmacists towards antimicrobial resistance and antimicrobial stewardship in Libya: a cross-sectional study.

Background: Community pharmacists play a vital role in promoting appropriate use of antibiotics in the community. This study evaluated the practices and perceptions of community pharmacists towards antibiotic use, antibiotic resistance, and antimicrobial stewardship in Libya.

Methods: A cross-sectional study was conducted among community pharmacists in Libya using a 47-item validated, pre-tested online questionnaire.

Integrated analysis of Hashtgerd plain deformation, using Sentinel-1 SAR, geological and hydrological data.

Due to its proximity to Tehran, the Hashtgerd catchment in Iran is an important region that has experienced alarming subsidence rates in recent years. This study estimated the ground surface deformation in the Hashtgerd plain between 2015 and 2020 using Sentinel-1 SAR data and InSAR technique. The average LOS displacement of the ascending and descending tracks was - 23 cm/year and - 22 cm/year, respectively.

Jaw Swelling Back with Vengeance.

Rhabdomyosarcoma (RMS) is a highly aggressive lesion and is commonly seen in children below the age of 10 years. The survival rate is not very high as an early diagnosis is often difficult. However, the treatment involves mainly surgery followed by chemotherapy and sometimes radiotherapy.

Comparison of lidocaine-dexmedetomidine and lidocaine-saline on the characteristics of the modified forearm bier block: A clinical trial.

Background And Aims: Forearm Modified Bier Block (FMBB) reduces local anesthetic systemic toxicity risks compared to the traditional method. This study was designed and implemented to compare the effects of lidocaine-dexmedetomidine (LD) and lidocaine-saline (LS) on the characteristics of the MFBB in distal forearm and hand surgery.

Material And Methods: In this randomized double-blind trial, which was conducted after obtaining institutional ethical committee approval, 60 patients were enrolled and randomly divided into two groups.

Coral health assessment in Malaysia: a case study of Pulau Anak Datai, Langkawi.

The coral health of Pulau Anak Datai (PAD), located off the northwest of Langkawi, Malaysia, was assessed using the Coral Health Index (CHI) method. Three ecological parameters, namely, benthic cover, fish biomass, and microbes (Vibrio) were determined at four sites around the island in 2019. In addition, community parameters such as coral mortality index, coral richness, relative abundance, diversity index, Evenness tests, and reef morphology were measured for each site.

Assessments of the Ecological and Health Risks of Potentially Toxic Metals in the Topsoils of Different Land Uses: A Case Study in Peninsular Malaysia.

Human activities due to different land uses are being studied widely in many countries. This study aimed to determine the ecological risks and human health risk assessments (HHRA) of Cd, Pb, Ni, Cu, and Zn in the topsoils of six land uses in Peninsular Malaysia. The ranges of the potentially toxic metals (PTMs) in the soils (mg/kg, dry weight) of this study were 0.

Prevalence of Pediatric Onset Multiple Sclerosis in Saudi Arabia.

Background: The prevalence of multiple sclerosis (MS) appears to be increasing worldwide. However, data on the pediatric onset of MS is lacking, particularly in developing countries.

Objective: This study is aimed at reporting the current burden of the pediatric onset of MS in the five regions of Saudi Arabia.

Predation of Florida red scale (L.) by the metallic blue ladybeetle (Mulsant).

Florida red scale, Chrysomphalus aonidum (L.) is a species of armored scales, which attacks citrus crops. Biological control, particularly ladybeetles, are critical for its management in citrus production systems.