Publications by authors named "Shamaya L Whitby"
Article Synopsis
- - The study investigates how exposure to the environmental contaminant 2-aminoanthracene (2AA) during pregnancy might increase the risk of type 2 diabetes in offspring by affecting adipose tissue function.
- - Pregnant rats were given diets with varying levels of 2AA, and their offspring were analyzed for diabetes-related gene expression, serum glucose levels, and other health markers.
- - Findings show that exposure to 2AA resulted in gene changes related to diabetes, higher blood sugar levels, and larger fat cells in treated offspring, suggesting a combined effect with a high-fat diet increases diabetes risk.
Adipocyte dysfunction may be a critical link between obesity and insulin resistance as a result of abnormal fat storage and mobilization. Adipocytes uniquely secrete adipokines and cytokines, such as leptin and TNFα, wich promote insulin sensitivity. Previously we reported insulin-signaling related altered gene expression in animals exposed to 2-Aminoanthracene (2AA).
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