We compared the clinical, functional, and radiographic outcomes between pegged (37 knees in 37 patients) and stemmed (33 knees in 31 patients) tibial designs in patients undergoing primary cemented total knee arthroplasty (TKA) for osteoarthritis (OA). Outcomes were evaluated using the knee society score (KSS-Clinical and Function scores) and knee injury and osteoarthritis outcome score (KOOS-pain, symptoms, stiffness, and function scores) at 6, 12, and 24 months postoperatively. Pre- and postoperative radiographs were evaluated for alignment and tibial coverage.
View Article and Find Full Text PDFBackground: Previous studies have shown the effect of a unique therapy with a non-invasive biomechanical foot-worn device (AposTherapy) on Caucasian western population suffering from knee osteoarthritis. The purpose of the current study was to evaluate the effect of this therapy on the level of symptoms and gait patterns in a multi-ethnic Singaporean population suffering from knee osteoarthritis.
Methods: Fifty-eight patients with bilateral medial compartment knee osteoarthritis participated in the study.
J Mech Behav Biomed Mater
June 2013
In this study, the bone mineral density (BMD), geometry, macroscopic viscoelastic properties and mechanical strength in five different groups of Sprague-Dawley rats (sham operated, ovariectomized with vehicle, parathyroid hormone and/or ibandronate administration) were examined by peripheral quantitative computed tomography (pQCT), dynamic mechanical analysis (DMA) and three-point bending test. At the end of the study, storage modulus (E'), loss tangent (tanδ), ultimate force (Fu) and stiffness (S) had greatly decreased in vehicle-treated ovariectomized group as compared to sham group (p<0.05).
View Article and Find Full Text PDFSevere medio-patellofemoral osteoarthritis (MPFOA) is often managed with a total knee arthroplasty (TKA). Bicompartmental knee arthroplasty (BKA), as compared with TKA can offer a bone and ligament preserving solution for MPFOA. We aimed to compare the early clinical and functional outcomes of modular BKA (n = 16) with TKA (n = 20) in MPFOA.
View Article and Find Full Text PDFBesides bone mineral density (BMD), structural and nano-level viscoelastic properties of bone are also crucial determinants of bone strength. However, treatment induced viscosity changes in osteoporotic bone have seldom been characterized. In this study, the effects of anabolic, antiresorptive and concurrent treatments on ovariectomized rat bones were thoroughly analyzed using multiple bone strength parameters.
View Article and Find Full Text PDFOsteoporosis remains a challenging problem. Understanding the regulation on osteoclast and osteoblast by drugs has been of great interest. Both anabolic and anti-resorptive drugs yield positive results in the treatment of osteoporosis.
View Article and Find Full Text PDF