Publications by authors named "Shalu Thakur"
A series of multi-target organoselenides 3a-h has been synthesized with the advantages of a simple operation, and good yields of 66-89 % escorted by mechanistic enlightenment. The compounds 3b, 3c continued to exist as orthorhombic and trigonal, whereas 3d exist as monoclinic confirmed by the X-ray crystallography. Organoselenides 3c and 3f displayed the highest % radical scavenging potential with % inhibition of 98.
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- Colorectal cancer (CRC) is a complex disease linked to genetic changes and persistent gut inflammation, especially in conditions like inflammatory bowel disease (IBD), and it causes about 600,000 deaths yearly in developed countries.
- Recent studies have explored the use of HDAC inhibitors like SAHA for CRC treatment, but their clinical effectiveness is limited and can involve significant risks.
- In this research, a derivative called SelSA-1, which combines selenium with SAHA, showed improved safety and efficacy in both in vitro and in vivo models by reducing tumor incidence and possibly inducing cancer cell death through epigenetic modulation.
Purpose: The study is to evaluate the difference between outcomes of two high-dose-rate fractionation schedules in the treatment of intracavitary brachytherapy (ICBT) of cervical cancer.
Material And Methods: A retrospective analysis of 163 cervical cancer patients was completed. All patients received external beam radiotherapy (EBRT) to whole pelvis with concurrent weekly chemotherapy, followed by ICBT with either 7 Gy per fraction in three fractions (arm A) or 9 Gy per fraction in two fractions (arm B).