Publications by authors named "Shalini P Singh"
As part of the World Health Organization Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) surveillance in Suva, Fiji, cerebrospinal fluid (CSF) samples from suspected meningitis patients of all ages were examined by traditional methods (culture, Gram stain, and latex agglutination for bacterial antigen) and qPCR for Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Of 266 samples tested, pathogens were identified in 47 (17.7%).
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- Multidrug-resistant (MDR) typhoid, caused by a specific lineage of Salmonella called H58, has spread rapidly across Asia and Africa over the past 30 years, posing a significant global health threat.
- The research reveals that H58 is displacing antibiotic-sensitive strains and is linked to numerous transmissions, including ongoing MDR epidemics within Africa.
- The study highlights the genetic characteristics of the H58 lineage, providing insights that can help manage MDR typhoid and similar antibiotic-resistant bacteria globally.