Purification and biochemical characterization of DnaK and its transcriptional activator RpoH from Neisseria gonorrhoeae.

DnaK plays a central role in stress response in the important human pathogen Neisseria gonorrhoeae. The genes encoding the DnaK chaperone machine (DnaK/DnaJ/GrpE) in N. gonorrhoeae are transcribed from RpoH (σ(32))-dependent promoters.

Mechanism of Escherichia coli resistance to Pyrrhocoricin.

Due to their lack of toxicity to mammalian cells and good serum stability, proline-rich antimicrobial peptides (PR-AMPs) have been proposed as promising candidates for the treatment of infections caused by antimicrobial-resistant bacterial pathogens. It has been hypothesized that these peptides act on multiple targets within bacterial cells, and therefore the likelihood of the emergence of resistance was considered to be low. Here, we show that spontaneous Escherichia coli mutants resistant to pyrrhocoricin arise at a frequency of approximately 6 × 10(-7).

Status of the tinnitus management program in India-A Survey.

Objective: The aim of the study is to figure out the status of tinnitus management program (TMP) being conducted in India, to estimate the use of different tinnitus management program, to study the role of various professionals involved and document the current practices of audiologist in country.

Design: A questionnaire on "tinnitus management survey" was developed and distributed to 150 institutions all over India.

Results And Conclusion: The return rate of the Questionnaire was 32.